Wells syndrome

Weins, Andreas Benedikt; Biedermann, Tilo; Weiss, Th.; Weiss, Johannes M.

doi:10.1111/ddg.13132

Cited by 30 publications

(59 citation statements)

References 30 publications

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“…Eosinophilic cellulitis is potentially associated with EGPA, HES, UC, or other causes, but the etiology is unknown (274, 275). The typical histopathological sign is flame figures, the focal accumulation of disintegrating eosinophils and collagen fibers.…”

Section: Role Of Eosinophils In Autoimmune Diseasesmentioning

confidence: 99%

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Eosinophils in Autoimmune Diseases

2017

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Eosinophils are multifunctional granulocytes that contribute to initiation and modulation of inflammation. Their role in asthma and parasitic infections has long been recognized. Growing evidence now reveals a role for eosinophils in autoimmune diseases. In this review, we summarize the function of eosinophils in inflammatory bowel diseases, neuromyelitis optica, bullous pemphigoid, autoimmune myocarditis, primary biliary cirrhosis, eosinophilic granulomatosis with polyangiitis, and other autoimmune diseases. Clinical studies, eosinophil-targeted therapies, and experimental models have contributed to our understanding of the regulation and function of eosinophils in these diseases. By examining the role of eosinophils in autoimmune diseases of different organs, we can identify common pathogenic mechanisms. These include degranulation of cytotoxic granule proteins, induction of antibody-dependent cell-mediated cytotoxicity, release of proteases degrading extracellular matrix, immune modulation through cytokines, antigen presentation, and prothrombotic functions. The association of eosinophilic diseases with autoimmune diseases is also examined, showing a possible increase in autoimmune diseases in patients with eosinophilic esophagitis, hypereosinophilic syndrome, and non-allergic asthma. Finally, we summarize key future research needs.

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Section: Role Of Eosinophils In Autoimmune Diseasesmentioning

confidence: 99%

“…Early stages are characterized by predominantly eosinophilic infiltration (274). Blood eosinophilia is present in 15–67% of patients (275). Blood eosinophils from patients with eosinophilic cellulitis express the high-affinity IL-2 receptor CD25 (276).…”

Section: Role Of Eosinophils In Autoimmune Diseasesmentioning

confidence: 99%

Eosinophils in Autoimmune Diseases

2017

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“…Anschließend erzeugt die Degranulation der eosinophilen Granula auf den Kollagenfasern Flammenfi guren, gefolgt von einer granulomatösen Reaktion [ 7 ] . Eine derartige Histopathologie kann auch bei anderen Erkrankungen, die mit einer Gewebseosinophilie zusammenhängen, wie beim Pemphigoid, Ekzem, bei der Parasitose oder beim Arzneimittelexanthem festgestellt werden [ 2,7 ] . Eine derartige Histopathologie kann auch bei anderen Erkrankungen, die mit einer Gewebseosinophilie zusammenhängen, wie beim Pemphigoid, Ekzem, bei der Parasitose oder beim Arzneimittelexanthem festgestellt werden [ 2,7 ] .…”

Section: Erythematös-violette Plaques Am Stamm Und An Den Extremitäteunclassified

“…Eine derartige Histopathologie kann auch bei anderen Erkrankungen, die mit einer Gewebseosinophilie zusammenhängen, wie beim Pemphigoid, Ekzem, bei der Parasitose oder beim Arzneimittelexanthem festgestellt werden [ 2,7 ] . Das Wells-Syndrom hat mit einem hohen Anteil spontaner Remissionen normalerweise einen gutartigen Verlauf, wie auch bei unserer Patientin festgestellt wurde [ 2 ] . Die Eosinophilenwerte korrelieren mit der Aktivität der Erkrankung [ 3 ] .…”

Section: Erythematös-violette Plaques Am Stamm Und An Den Extremitäteunclassified

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Erythematous‐violaceous plaques on the trunk and extremities of a child

Matos-Pires

Coelho

Baptista

et al. 2018

J Deutsche Derma Gesell

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Vesicles and Bullae on the Right Cheek, Neck, and Both Hands

Zhu

Liao

2019

JAMA Dermatol

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A man in his 40s was admitted to the hospital with a 10-day history of edema and presented with vesicles and bullae on his right cheek, neck, back, both eyelids, and the dorsal surface of his hands (Figure 1A). Prior to presentation, he had been treated for herpes zoster with famciclovir for 1 week, during which the lesions kept developing and were accompanied with irregular fever (maximum temperature, 39°C). Physical examination revealed edema on both eyelids; multiple papules, blisters, and crusted erosions with thin exudation on his right cheek and neck; and erythematous plaques and tense blisters and bullae on his back and on the dorsal surface of both hands (Figure 1B). A full laboratory workup was performed for autoantibodies for systemic lupus erythematosus (SLE), pemphigus, and bullous pemphigoid; skin and bone-marrow biopsies and direct immunofluorescence were performed; and immunohistochemichal analysis, a swab of exudation, and bacterial, fungal, and atypical mycobacterial cultures from blood and tissue were also examined.

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Wells syndrome

Cited by 30 publications

References 30 publications

Eosinophils in Autoimmune Diseases

Eosinophils in Autoimmune Diseases

Erythematous‐violaceous plaques on the trunk and extremities of a child

Vesicles and Bullae on the Right Cheek, Neck, and Both Hands

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