Wells‐Syndrom

Weins, Andreas Benedikt; Biedermann, Tilo; Weiss, Th.; Weiss, Johannes M.

doi:10.1111/ddg.13132_g

Cited by 6 publications

(11 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Eosinophilic cellulitis/dermatitis (EC), also referred to as Wells’ syndrome, is a rare dermatological condition characterized by persistent urticarial plaques and sometimes blister formation, as well as an eosinophil infiltrate in the dermis (Fig. 3C ) [ 103 ]. Blood eosinophilia may be present.…”

Section: Clinical Patterns Of Eosinophilic Dermatosesmentioning

confidence: 99%

Eosinophils in skin diseases

et al. 2021

View full text Add to dashboard Cite

Eosinophil infiltration is a common finding in a broad spectrum of skin diseases, despite the fact that the skin is devoid of eosinophils under physiologic conditions. Although cutaneous eosinophilia is reactive, cytokine-mediated in most cases, diseases with an intrinsic mutation-mediated clonal expansion of eosinophils can also manifest on the skin. As eosinophils are involved in host defense, regulate immune responses, generate pruritus, induce remodeling and fibrosis, and can cause tissue damage, they have the capacity to actively contribute to the pathogenesis of diseases. Recent research provided deeper insights in the mechanisms, e.g., bacterial and viral clearance, blister formation, recruitment of cytotoxic T cells, and generation of pruritus, by which eosinophils might come into action. This review aims at providing an overview on the clinical presentations of eosinophil-associated dermatoses and the current understanding of their pathogenic role in these diseases. Further, we discuss the effects of therapies targeting eosinophils.

show abstract

Section: Clinical Patterns Of Eosinophilic Dermatosesmentioning

confidence: 99%

Eosinophils in skin diseases

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Although it is generally accepted to result from a hypersensitivity reaction,8–10 the pathogenesis of EC remains unknown, with some studies suggesting that T cells and IL‐5 may play an important role in the development of the condition 11 12. A multitude of trigger factors has been reported, including insect bites, drug reactions, immune‐mediated processes, infectious diseases and malignancies 8 10 13. Diagnosis is achieved by correlating clinical history, clinical features and histopathological findings and by exclusion of other conditions such as bullous pemphigoid, dermatophyte infections or arthropod bites 3 6…”

Section: Discussionmentioning

confidence: 99%

Canine acute eosinophilic dermatitis with oedema (Wells‐like syndrome) associated with T‐cell multicentric lymphoma

Alves¹,

Foale²,

Cerundolo³

et al. 2020

Vet Record Case Reports

View full text Add to dashboard Cite

A nine-year-old female neutered Boxer in clinical remission from T-cell multicentric lymphoma was presented for further investigation of multiple, non-painful, non-pruritic, oedematous, erythematous, serpiginous plaques. On examination, a very mild right superficial cervical lymphadenomegaly was also detected. Initial glucocorticoid treatment for a suspected hypersensitivity reaction was unsuccessful and the patient presented a week later with worsening of the dermatological signs. Cytology of peripheral lymph nodes was consistent with lymphoma relapse. Histopathology of skin biopsies was compatible with canine acute eosinophilic dermatitis with oedema, also known as Wells-like syndrome. Complete clinical resolution of the skin lesions and the peripheral lymphadenomegaly was achieved with six weeks of lomustine chemotherapy. To the authors’ knowledge, this is the first description of canine acute eosinophilic dermatitis with oedema suspected to be triggered by a multicentric lymphoma in a dog.

show abstract

“…If corticosteroids are not sufficiently effective or long‐term treatment is required, an attempt can be made with dapsone and cyclosporine A as well as antihistamines. There have also been reports (some of them individual case reports) on the use of azathioprine, tetracyclines, (hydroxy‐)chloroquine, tacrolimus, colchicine and other drugs . A recent publication reported on the successful use of mepolizumab (anti‐IL‐5 antibody).…”

Section: Wells Syndromementioning

confidence: 99%

Eosinophilic dermatoses

Peckruhn

Elsner

Tittelbach

2019

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Summary Eosinophilic dermatoses are a heterogeneous group of diseases, characterized by an eosinophil‐rich infiltrate and/or degranulation of eosinophils. Blood eosinophilia may be an associated feature. Typical, albeit not specific histological findings include ‘flame figures’, which are caused by the accumulation of cationic proteins released by eosinophils and subsequent collagen denaturation. “Classic” eosinophilic dermatoses include eosinophilic cellulitis (Wells syndrome), granuloma faciale, eosinophilic fasciitis (Shulman syndrome) and eosinophilic folliculitis (Ofuji disease). In addition, there is a multitude of skin diseases that present with varying degrees of eosinophilic infiltration. These include atopic dermatitis, bullous pemphigoid, urticaria, allergic contact dermatitis, prurigo nodularis, arthropod bite reaction, parasitic infections, and drug hypersensitivity. Even though these disorders share a common characteristic (tissue eosinophilia), they differ greatly in their clinical presentation.

show abstract

Wells‐Syndrom

Cited by 6 publications

References 30 publications

Eosinophils in skin diseases

Eosinophils in skin diseases

Canine acute eosinophilic dermatitis with oedema (Wells‐like syndrome) associated with T‐cell multicentric lymphoma

Eosinophilic dermatoses

Contact Info

Product

Resources

About