Well Differentiation and Intact Smad4 Expression Are Specific Features of Groove Pancreatic Ductal Adenocarcinomas

Izumi, Sadanobu; Nakamura, Satoko; Mano, Shohei; Akaki, Shiro

doi:10.1097/mpa.0000000000000260

Cited by 8 publications

(6 citation statements)

References 21 publications

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“…However, a small amount of pancreatic tissue occasionally appear at the groove area. [4,13] Therefore, either cancer or pancreatitis can occur in the pancreatic groove, although both of them are rarely seen clinically.…”

Section: Discussionmentioning

confidence: 99%

“…It has been claimed that duodenal obstruction with nausea/vomiting is often an initial presenting symptom for most cases, but obstructive jaundice does not always happen until the disease progresses. [2,4,5] The intrapancreatic common bile duct is only involved at the advanced stage. [2] Three out of 4 patients in our study presented nausea/vomiting, with only 1 showing signs of jaundice.…”

Section: Discussionmentioning

confidence: 99%

“…[1–3] Radiography often shows a plate-like mass for this disease, and histopathology reveals duodenal invasion which may cause duodenal stricture in the advanced-stage of the disease. [2–4] The most common symptoms of pancreatic groove cancer can be abdominal pain and vomiting due to the duodenal stenosis. [5,6] Most of the reported cases present clinical pictures similar to those seen in groove pancreatitis which is a more common clinical entity.…”

Section: Introductionmentioning

confidence: 99%

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Pancreatic groove cancer

Chen²,

Shyr³

et al. 2017

Medicine

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Pancreatic groove cancer is very rare and can be indistinguishable from groove pancreatitis. This study is to clarify the characteristics, clinical features, managements, and survival outcomes of this rare tumor.Brief descriptions were made for each case of pancreatic groove cancer encountered at our institute. Individualized data of pancreatic groove cancer cases described in the literature were extracted and added to our database to expand the study sample size for a more complete analysis.A total of 33 patients with pancreatic groove cancer were included for analysis, including 4 cases from our institute. The median tumor size was 2.7 cm. The most common symptom was nausea or vomiting (89%), followed by jaundice (67%). Duodenal stenosis was noted by endoscopy in 96% of patients. The histopathological examination revealed well differentiated tumor in 43%. Perineural invasion was noted in 90%, and lymphovascular invasion and lymph node involvement in 83%. Overall 1-year survival rate was 93.3%, and 3- or 5-year survival rate was 62.2%, with a median survival of 11.0 months. Survival outcome for the well-differentiated tumors was better than those of the moderate/poorly differentiated ones.Early involvement of duodenum causing vomiting is often the initial presentation, but obstructive jaundice does not always happen until the disease progresses. Tumor differentiation is a prognostic factor for survival outcome. The possibility of pancreatic groove cancer should be carefully excluded before making the diagnosis of groove pancreatitis for any questionable case.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pancreatic groove cancer

Chen²,

Shyr³

et al. 2017

Medicine

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“…A total of 10 related articles were selected for the study. [1][2][3][4][5]7,[9][10][11][12] Cases without individualized data and duplicate cases reported in literature were excluded from the analysis. The data pool from the related literature and our patients' cases were analyzed to determine the characteristics of pancreatic groove cancer including demographics, tumor size, clinical presentations, histopathology, treatment, and survival outcomes.…”

Section: Methodsmentioning

confidence: 99%

“…[1][2][3] Radiography often shows a plate-like mass for this disease, and histopathology reveals duodenal invasion which may cause duodenal stricture in the advanced-stage of the disease. [2][3][4] The most common symptoms of pancreatic groove cancer can be abdominal pain and vomiting due to the duodenal stenosis. [5,6] Most of the reported cases present clinical pictures similar to those seen in groove pancreatitis which is a more common clinical entity.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic groove cancer

Shyr

Wang

2019

Pancreatology

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Pancreatic groove cancer is very rare and can be indistinguishable from groove pancreatitis. This study is to clarify the characteristics, clinical features, managements, and survival outcomes of this rare tumor.Brief descriptions were made for each case of pancreatic groove cancer encountered at our institute. Individualized data of pancreatic groove cancer cases described in the literature were extracted and added to our database to expand the study sample size for a more complete analysis.A total of 33 patients with pancreatic groove cancer were included for analysis, including 4 cases from our institute. The median tumor size was 2.7 cm. The most common symptom was nausea or vomiting (89%), followed by jaundice (67%). Duodenal stenosis was noted by endoscopy in 96% of patients. The histopathological examination revealed well differentiated tumor in 43%. Perineural invasion was noted in 90%, and lymphovascular invasion and lymph node involvement in 83%. Overall 1-year survival rate was 93.3%, and 3-or 5-year survival rate was 62.2%, with a median survival of 11.0 months. Survival outcome for the well-differentiated tumors was better than those of the moderate/poorly differentiated ones.Early involvement of duodenum causing vomiting is often the initial presentation, but obstructive jaundice does not always happen until the disease progresses. Tumor differentiation is a prognostic factor for survival outcome. The possibility of pancreatic groove cancer should be carefully excluded before making the diagnosis of groove pancreatitis for any questionable case.Abbreviations: CA 19-9 = carbohydrate antigen 19-9, CT = computerized tomography, MRI = magnetic resonance imaging.

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Atypical and uncommon CT and MR imaging presentations of pancreatic ductal adenocarcinoma

Gong

2021

Abdom Radiol

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Well Differentiation and Intact Smad4 Expression Are Specific Features of Groove Pancreatic Ductal Adenocarcinomas

Cited by 8 publications

References 21 publications

Pancreatic groove cancer

Pancreatic groove cancer

Pancreatic groove cancer

Atypical and uncommon CT and MR imaging presentations of pancreatic ductal adenocarcinoma

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