Well-Differentiated Thyroid Carcinoma in Hong Kong Chinese Patients Under 21 Years of Age: A 35-Year Experience1

Lee, Yee-Man; Lo, Chung‐Yau; Lam, Alfred King‐Yin; Wan, Koon-Yat; Tam, Paul Kwong‐Hang

doi:10.1016/s1072-7515(02)01139-0

Cited by 22 publications

(15 citation statements)

References 16 publications

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“…Our results suggest that male gender, advanced tumor stage, and clinical lymphadenopathy are risk factors for DFS in TNM stage I pediatric DTC patients. In the literature, advanced tumor stage, multifocality, lymphadenopathy, distant metastasis, and lower patient age are considered major risk factors for worse prognosis [6,11,14-17,20,21]. Male gender is also a risk factor in pediatric patients [2,11,14].…”

Section: Discussionmentioning

confidence: 99%

“…Finally, long-term follow-up is considered essential to evaluate outcomes in pediatric patients [6,35]. A shorter follow-up period may result in inappropriate decision making of the treatment strategy.…”

Section: Discussionmentioning

confidence: 99%

“…Follicular thyroid carcinoma (FTC) is the next common form, but is usually quite rare in pediatric patients. Advanced tumor manifestations, such as large or extensive tumor, multifocality, lymphadenopathy, and synchronous lung metastasis at diagnosis, are more evident and are indicated to be risk factors in pediatric patients [6,14-18]. In addition, the lower age population develops a worse prognosis compared to young adult or adolescent patients [11,15,17,19-22].…”

Section: Introductionmentioning

confidence: 99%

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Pediatric differentiated thyroid carcinoma in stage I: risk factor analysis for disease free survival

et al. 2009

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BackgroundTo examine the outcomes and risk factors in pediatric differentiated thyroid carcinoma (DTC) patients who were defined as TNM stage I because some patients develop disease recurrence but treatment strategy for such stage I pediatric patients is still controversial.MethodsWe reviewed 57 consecutive TNM stage I patients (15 years or less) with DTC (46 papillary and 11 follicular) who underwent initial treatment at Ito Hospital between 1962 and 2004 (7 males and 50 females; mean age: 13.1 years; mean follow-up: 17.4 years). Clinicopathological results were evaluated in all patients. Multivariate analysis was performed to reveal the risk factors for disease-free survival (DFS) in these 57 patients.ResultsExtrathyroid extension and clinical lymphadenopathy at diagnosis were found in 7 and 12 patients, respectively. Subtotal/total thyroidectomy was performed in 23 patients, modified neck dissection in 38, and radioactive iodine therapy in 10. Pathological node metastasis was confirmed in 37 patients (64.9%). Fifteen patients (26.3%) exhibited local recurrence and 3 of them also developed metachronous lung metastasis. Ten of these 15 achieved disease-free after further treatments and no patients died of disease. In multivariate analysis, male gender (p = 0.017), advanced tumor (T3, 4a) stage (p = 0.029), and clinical lymphadenopathy (p = 0.006) were risk factors for DFS in stage I pediatric patients.ConclusionMale gender, tumor stage, and lymphadenopathy are risk factors for DFS in stage I pediatric DTC patients. Aggressive treatment (total thyroidectomy, node dissection, and RI therapy) is considered appropriate for patients with risk factors, whereas conservative or stepwise approach may be acceptable for other patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pediatric differentiated thyroid carcinoma in stage I: risk factor analysis for disease free survival

et al. 2009

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“…However, unlike PTC, FTC is prone to early hematogenous metastases, which occurs even in the absence of cervical node involvement (383,384). Despite that, conventional FTC has an excellent prognosis when diagnosed during childhood, and long-term survival is the norm (8,385,386).…”

Section: Recommendation Rating: C [E1] Follicular Thyroid Cancermentioning

confidence: 99%

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Francis

Waguespack

Bauer

et al. 2015

Thyroid

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1,365

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Background: Previous guidelines for the management of thyroid nodules and cancers were geared toward adults. Compared with thyroid neoplasms in adults, however, those in the pediatric population exhibit differences in pathophysiology, clinical presentation, and long-term outcomes. Furthermore, therapy that may be recommended for an adult may not be appropriate for a child who is at low risk for death but at higher risk for long-term harm from overly aggressive treatment. For these reasons, unique guidelines for children and adolescents with thyroid tumors are needed. Methods: A task force commissioned by the American Thyroid Association (ATA) developed a series of clinically relevant questions pertaining to the management of children with thyroid nodules and differentiated thyroid cancer (DTC). Using an extensive literature search, primarily focused on studies that included subjects £ 18 years of age, the task force identified and reviewed relevant articles through April 2014. Recommendations were made based upon scientific evidence and expert opinion and were graded using a modified schema from the United States Preventive Services Task Force. Results: These inaugural guidelines provide recommendations for the evaluation and management of thyroid nodules in children and adolescents, including the role and interpretation of ultrasound, fine-needle aspiration cytology, and the management of benign nodules. Recommendations for the evaluation, treatment, and follow-up of children and adolescents with DTC are outlined and include preoperative staging, surgical management, postoperative staging, the role of radioactive iodine therapy, and goals for thyrotropin suppression. Management algorithms are proposed and separate recommendations for papillary and follicular thyroid cancers are provided.

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“…Превали рую-щей гистологической формой является па-пил лярная карцинома, составляющая более 90% от всех форм тиреоидного рака [2,8,12,17]. Наблюдения анапластического РЩЖ у детей единичные [13,14].…”

Section: Introductionunclassified

Children Thyroid Cancer treatment in Saint-Petersburg Endocrine SurgeryCenter and Mayo Clinic

Романчишен¹,

Thompson

2015

Endo Serg

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Well-Differentiated Thyroid Carcinoma in Hong Kong Chinese Patients Under 21 Years of Age: A 35-Year Experience1

Cited by 22 publications

References 16 publications

Pediatric differentiated thyroid carcinoma in stage I: risk factor analysis for disease free survival

Pediatric differentiated thyroid carcinoma in stage I: risk factor analysis for disease free survival

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Children Thyroid Cancer treatment in Saint-Petersburg Endocrine SurgeryCenter and Mayo Clinic

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