Well-differentiated, pedunculated liposarcoma of the hypopharynx

Abstract

Well-differentiated liposarcoma is the most common form of liposarcoma, but is only exceptionally reported in the hypopharynx. The main symptoms are related to compression of adjacent structures. Imaging findings are nonspecific. Only histological examination can distinguish liposarcoma from other benign oesophageal tumours. Standard treatment consists of wide, complete resection, which is not always possible in the neck. Long-term follow-up of these patients is essential in order to rapidly detect recurrence.

Liposarcoma of the Arygepiglottic Fold

“…As in our patient, WDL and DDL may share similar genetic signatures (e.g., a high level amplification of MDM2) [1]. Laryngeal and hypopharyngeal liposarcoma is an extremely rare condition with only three cases of the DDL histological subtype reported in the international literature [235].…”

“…Liposarcoma is the most common form of soft-tissue sarcoma, most frequently found in limbs and the retroperitoneum. Laryngeal and hypopharyngeal localizations are extremely rare; 40 cases have been reported in the literature up to now, three of which were of the dedifferentiated (DDL) histological subtype [23]. We report a case of DDL liposarcoma arising from the supraglottic side of the arygepiglottic fold.…”

Intrinsic Laryngeal Lipoma Treated with Transoral CO₂ Laser Microsurgery: An Unusual Case Report

“…For these reasons, photocoagulation of the margins and the wound bed can prevent an unlikely but still possible histopathological surprise such as lipoma-like liposarcoma, as well as in cordectomy [ 35 ]. We think that the choice of the endoscopic approach using a CO 2 laser and the use of the photocoagulation technique was a rational approach given the fact that sometimes these lesions are only identified on histological examination can be defined as benign lesions because preoperative imaging has a probative but not absolute value and only the histopathological examination allows to define the lesion exactly [ 36 ].…”

Liposarcoma: A Pictorial and Literature Review

“…[13] Liposarcomas from the hypopharynx, which are very rare and <28 cases had been reported until 2016, arise from the piriform sinus, they present clinically with progressive dysphagia and weight loss due to mass effect. [14] Liposarcomas from the head and neck commonly are <10 cm in size and they can be polypoid and pedunculated, giving them a very similar gross appearance to benign polyps, which can delay the diagnosis. [13] In MRI, which is the imaging modality of choice, WDLs of the hypopharynx can be misdiagnosed with other benign lipomatous tumors, for this reason, an histologic diagnosis is necessary.…”

“…For nonoperable lesions or incomplete resections, radiotherapy may be the best treatment option. [14] Laryngeal liposarcoma (LLS) is also a rare LS, it is more common in males with a reported male-to-female ratio of 8:1 and a mean age of 55 years. The most common region affected in the larynx is the supraglottic area, and it can present with symptoms related to obstruction such as snoring, dysphagia, weight loss, and hoarseness.…”