Well-Differentiated Papillary Mesothelioma of the Peritoneum Is Genetically Distinct from Malignant Mesothelioma

Shrestha, Raunak; Nabavi, Noushin; Volik, Stanislav V.; Anderson, Shawn; Haegert, Anne; McConeghy, Brian; Sar, Funda; Brahmbhatt, Sonal; Bell, Robert H.; Bihan, Stéphane Le; Wang, Yuzhuo; Churg, Andrew

doi:10.3390/cancers12061568

Cited by 26 publications

(19 citation statements)

References 35 publications

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“…Two recent studies suggest that BAP1 alterations do not occur in WDPMT and that these lesions are genetically distinct from malignant mesothelioma [21,22]. Sun et al also reported that 94% of peritoneal WDPMT was labelled with PAX-8 on IHC [3].…”

Section: Discussionmentioning

confidence: 99%

Progression of Well-Differentiated Papillary Mesothelial Tumour to Mesothelioma in a Patient with Ehlers Danlos Syndrome

Prabhakaran

Hussey

O’Byrne

et al. 2021

JMP

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Well-differentiated papillary mesothelioma has been renamed well-differentiated papillary mesothelial tumour (WDPMT) in the current WHO classification because all mesotheliomas are now regarded as malignant. WDPMT is now defined as a non-invasive papillary mesothelial proliferation, with retained labelling for BAP1-desirable. The current WHO classification also includes mesothelioma in situ (MIS), which is defined as pre-invasive flat or papillary proliferation of mesothelial cells with a loss of BAP1 or MTAP. WDPMT has been variably defined in the past but was thought to occur more commonly in women and pursue a more indolent course than mesothelioma, but its progression to invasive disease has occasionally been reported. Here, we report a case of a 68-year-old woman with a history of asbestos exposure and an underlying diagnosis of Ehlers Danlos syndrome who was diagnosed with symptomatic WDPMT of the peritoneum that progressed to mesothelioma within two years. On retrospective analysis, the WDPMT showed a loss of BAP1. We suggest that a loss of BAP1 in WDPMT should be reported, since these lesions may show aggressive behaviour, and that they may best be regarded as similar to mesothelioma in situ.

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Section: Discussionmentioning

confidence: 99%

Progression of Well-Differentiated Papillary Mesothelial Tumour to Mesothelioma in a Patient with Ehlers Danlos Syndrome

Prabhakaran

Hussey

O’Byrne

et al. 2021

JMP

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“…1,4–6 Genome-wide sequencing analysis shows that WDPM has a genetic profile distinct from that of malignant mesothelioma, with a lack of copy number alterations in genes characteristic of peritoneal and pleural mesothelioma: BAP1 , SETD2 , PBRM1 , SMARCC1 , CDKN2A/B , LATS1/2 , and NF2 . 7,8 Adenomatoid tumors are also relatively uncommon benign tumors of mesothelial origin that usually occur in the male or female genital tract. 9 Although the American Society of Clinical Oncology published a clinical practice guideline on fertility preservation for adults and children with cancer in 2006, which has been updated periodically, 10,11 therapeutic strategies for WDPM with adenomatoid tumor are not currently described.…”

Section: Discussionmentioning

confidence: 99%

Peritoneal well-differentiated papillary mesothelioma associated with infertility in a 37-year-old woman

Pang

Liu

et al. 2021

J Int Med Res

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Well-differentiated papillary mesothelioma (WDPM) is an uncommon mesothelial tumor. The lesions may be single or multiple and usually behave in a benign or indolent fashion, sometimes persisting for many years. In the present case, a 37-year-old woman had experienced primary infertility for 12 years, and a diagnostic laparoscopy was performed. Approximately 200 mL of dark red, free fluid in the pelvis and more than 10 yellow-white nodules on the surface of the right round ligament, sacrum ligament, right fallopian tube, and both sides of the uterus were found. A lesionectomy was performed and immunohistochemical markers indicated WDPM with adenomatoid tumor. The patient was monitored by computed tomography and serum CA125 (cancer antigen 125) levels for 49 months with no recurrence. WDPM and adenomatoid tumor are both benign tumors of mesothelial origin. Because of the lack of effective radical treatment, regular follow-up is sufficient. However, the effects of estrogen and progesterone on WDPM and adenomatoid tumors during ovulation or pregnancy remains unclear. Although WDPM is not life threatening, a strategy to fulfill the fertility requirements of women with this condition is a new challenge for infertility doctors.

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“…54 However, frequent genetic alterations of BAP1, NF2 and CDKN2A/2B were not detected in well-differentiated papillary mesothelioma, suggesting different tumorigenic pathways in the mesothelium. 55 The expression of CD146/MUC18/MCAM (melanoma cell adhesion molecule) was demonstrated for distinguishing malignancy from benign mesothelium in cytology of human MM 56 and associated with short lifespan in rat MM; 57 however, the utility of CD146 expression may not be helpful for separating MM from benign mesothelium in paraffin-embedded tissue section, due to the positivity in the plasma membrane of vascular endothelial cells and some stromal cells. 58…”

Section: Pathogenesis Of MMmentioning

confidence: 99%

Asbestos‐induced mesothelial injury and carcinogenesis: Involvement of iron and reactive oxygen species

Okazaki

2021

Pathology International

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Asbestos fibers have been used as an industrial and construction material worldwide due to their high durability and low production cost. Commercial usage of asbestos is currently prohibited in Japan; however, the risk of asbestos-induced malignant mesothelioma (MM) remains. According to epidemiological data, the onset of MM is estimated to occur after a latent period of 30-40 years from initial exposure to asbestos fibers; thus, the continuous increase in MM is a concern. To explore the molecular mechanisms of MM using animal models, iron saccharate with iron chelatorinduced sarcomatoid mesothelioma (SM) revealed hallmarks of homozygous deletion of Cdkn2a/2b by aCGH and microRNA-199/214 by expression microarray. Oral treatment of iron chelation by deferasirox decreased the rate of high-grade SM. Moreover, phlebotomy delayed MM development in crocidolite-induced MM in rats. In Divalent metal transporter 1 (Dmt1) transgenic mice, MM development was delayed because of low reactive oxygen species (ROS) production. These results indicate the importance of iron and ROS in mesothelial carcinogenesis. The aims of this review focus on the pathogenesis of elongated mineral particles (EMPs), including asbestos fibers and multiwalled carbon nanotubes (MWCNTs) that share similar rod-like shapes in addition to the molecular mechanisms of MM development.

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Well-Differentiated Papillary Mesothelioma of the Peritoneum Is Genetically Distinct from Malignant Mesothelioma

Cited by 26 publications

References 35 publications

Progression of Well-Differentiated Papillary Mesothelial Tumour to Mesothelioma in a Patient with Ehlers Danlos Syndrome

Progression of Well-Differentiated Papillary Mesothelial Tumour to Mesothelioma in a Patient with Ehlers Danlos Syndrome

Peritoneal well-differentiated papillary mesothelioma associated with infertility in a 37-year-old woman

Asbestos‐induced mesothelial injury and carcinogenesis: Involvement of iron and reactive oxygen species

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