Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review

Thway, Khin

doi:10.1053/j.semdp.2019.02.006

Cited by 172 publications

(234 citation statements)

References 113 publications

Supporting

Mentioning

227

Contrasting

Unclassified

Order By: Relevance

“…When it comes to carcinomas, it has been suggested that immunohistochemistry for p63/p40 and CK5/6 have discriminatory power to differentiate a primary adnexal carcinoma vs a metastatic one . In our case all lineage‐specific markers were negative suggesting mesenchymal origin and in light of the patient's known primary, CDK4 and MDM2 were highly suggestive of dedifferentiated liposarcoma . We cannot overemphasize the importance of clinico‐pathologic correlation as these markers are not lineage‐specific; among others up to 30% of melanomas harbor MDM2 amplification with corresponding protein expression detected by immunohistochemistry …”

Section: Discussionmentioning

confidence: 58%

“…The latter can morphologically resemble other entities such as carcinoma, mesothelioma, or melanoma causing diagnostic difficulties. The genetic hallmark of ALT/WDL and DDL is amplification of 12q13‐15 region that harbors MDM2 and CDK4 genes, and its detection by fluorescence in situ hybridization or immunohistochemistry has become standard practice . Herein we present a case of DDL with epithelioid features involving the skin to raise awareness of a potential diagnostic pitfall.…”

Section: Introductionmentioning

confidence: 98%

“…Liposarcoma represents roughly 15%‐25% of all reported sarcomas and is the most prevalent form of sarcoma in adults . It is categorized into four distinct subtypes: atypical lipomatous tumor/well‐differentiated liposarcoma (WDL), dedifferentiated (DDL), myxoid, and pleomorphic (PLPS) .…”

Section: Introductionmentioning

confidence: 99%

“…It is categorized into four distinct subtypes: atypical lipomatous tumor/well‐differentiated liposarcoma (WDL), dedifferentiated (DDL), myxoid, and pleomorphic (PLPS) . DDL constitutes approximately 18% of all liposarcomas and is thought to represent a histopathologic progression of disease from WDL . Both are traditionally defined as diseases of late adulthood located within the deep soft tissue, especially the retroperitoneum.…”

Section: Introductionmentioning

confidence: 99%

“…Both are traditionally defined as diseases of late adulthood located within the deep soft tissue, especially the retroperitoneum. DDL is histopathologically recognized by areas of WDL juxtaposed with areas of deep, abrupt transitions to high‐grade, predominantly nonlipogenic sarcoma, which most commonly resembles spindle‐cell/pleomorphic sarcoma . The dedifferentiated components of DDL can have a great variety of histopathologic patterns .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Expanding the differential of cutaneous epithelioid tumors: A case of dedifferentiated liposarcoma with epithelioid features involving the skin, with review of the literature

et al. 2020

View full text Add to dashboard Cite

Liposarcomas are categorized into four distinct histopathological subtypes: atypical lipomatous tumors (ALT)/well-differentiated liposarcoma (WDL), dedifferentiated, myxoid, and pleomorphic. Dedifferentiated liposarcomas account for approximately 18% of all liposarcomas, characteristically arising in the deep soft tissue. They are reported to have lower rates of metastasis compared to other pleomorphic sarcomas. 1-3 The classic histopathologic appearance is ALT/WDL admixed or juxtaposed with a predominantly nonlipogenic sarcoma. Epithelioid features are rare, appearing in as few as 3% of tumors, and have not previously been reported in a superficial location. Herein, we present a 57-year-old male with intradermal and subcutaneous metastasis of his known deep dedifferentiated liposarcoma with epithelioid features.By H&E the tumor featured cords and sheets of crowded, plump, epithelioid cells with thick nuclear membranes and prominent nucleoli, which raised a broad differential including carcinoma and melanoma. By immunohistochemistry the tumor was diffusely positive for MDM2 and CDK4, on the other hand stains for Sox10, Melan A, MITF, CKAE1/3, desmin, and S100 protein were negative. This case serves as an opportunity to raise awareness of this rare morphological subtype, which can involve the skin and mimic epithelial and melanocytic malignancies. It can be a potential diagnostic pitfall, especially if metastases are the first presentation. K E Y W O R D S cutaneous, dedifferentiated, epithelioid, liposarcoma, MDM2, metastasis

show abstract

Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Expanding the differential of cutaneous epithelioid tumors: A case of dedifferentiated liposarcoma with epithelioid features involving the skin, with review of the literature

et al. 2020

View full text Add to dashboard Cite

show abstract

Clinical characteristics and management of primary retroperitoneal sarcoma: A literature review

Yamagata,

Komiyama,

Iwata

2023

Annals of Gastroent Surgery

View full text Add to dashboard Cite

Retroperitoneal sarcoma (RPS) is a rare tumor classified into many histological types. It is also often detected only after it has grown to a considerable size and requires extensive resection of the surrounding organs, making it difficult to offer optimal patient‐tailored management. Evidence supporting specific treatment modalities for RPS is insufficient, owing to its rarity. The Japanese clinical practice guidelines for RPS were published in December 2021, with the aim of accumulating existing evidence and indicating the optimal practice for RPS. These guidelines provide important clinical questions (CQs) concerning the diagnosis and treatment of RPS. This review, with a particular focus on primary RPS, attempts to introduce clinical problems in the diagnosis and treatment of RPS and to assess those problems along with the CQs in the guidelines. According to these guidelines, although chemotherapy and radiotherapy are expected to have therapeutic effects, the level of evidence to support these treatments is not very high at present. Accordingly, complete resection of the tumor is the first and only option for managing primary RPS. However, as with other tumors, the demand for multidisciplinary treatment for RPS is increasing. These guidelines will undoubtedly represent a milestone in clinical practice in relation to RPS in the future, and further evidence is expected to be accumulated based on the CQs that have been proposed.

show abstract

Encapsulated fat necrosis mimicking abdominal liposarcoma: A case report and literature review

Watanabe

Osaki

Tatebe

et al. 2020

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review

Cited by 172 publications

References 113 publications

Expanding the differential of cutaneous epithelioid tumors: A case of dedifferentiated liposarcoma with epithelioid features involving the skin, with review of the literature

Expanding the differential of cutaneous epithelioid tumors: A case of dedifferentiated liposarcoma with epithelioid features involving the skin, with review of the literature

Clinical characteristics and management of primary retroperitoneal sarcoma: A literature review

Encapsulated fat necrosis mimicking abdominal liposarcoma: A case report and literature review

Contact Info

Product

Resources

About