Well-differentiated inflammatory liposarcoma with metastasis in a 6-y-old cat

Abstract

Liposarcomas are rare malignant tumors showing adipocytic differentiation. We report a well-differentiated liposarcoma in a 6-y-old, male neutered cat with a prominent inflammatory component and metastatic spread to the lungs. The patient was initially presented because of fever, lethargy, and a firm subcutaneous inguinal mass. A Tru-cut biopsy of the mass revealed a mixture of well-differentiated adipocytes and lymphoplasmacytic-histiocytic inflammation, interpreted as panniculitis. The mass was surgically excised but recurred 4 mo later. A second excisional biopsy yielded similar histologic findings. A third recurrence of the mass was associated with lung nodules. Histopathology of the recurring and metastatic masses confirmed the diagnosis of well-differentiated inflammatory liposarcoma with pulmonary metastases. The neoplasm had an intense inflammatory component, which obscured the underlying features of liposarcoma and made differentiation from steatitis difficult. This inflammatory variant of a well-differentiated liposarcoma should be considered as a differential in tumorous steatitis-like lesions.

Skin and Subcutaneous Tumors

“…They consist of malignant lipoblasts and mesenchymal tissue. Most liposarcomas are cutaneous, but they can also develop in the abdominal cavity (Alvarez et al 2017;Baez et al 2004).…”

Primary well differentiated hepatic liposarcoma in a meerkat (<i>Suricata suricatta</i>)

“…In veterinary practice, classification of liposarcoma is primarily based on their histologic characteristics and categorized by well-differentiated, pleomorphic and myxoid types [ 3 , 11 ]. Compared to liposarcoma arising in the soft tissues, visceral liposarcoma is extremely rare in domestic animals and has been reported in canine, feline, oryx, equine and macaque [ 2 , 4 , 12 , 19 , 20 ].…”