Well-Differentiated Fetal Adenocarcinoma of the Lung in a 20-Year-Old Woman

Abstract

: A 20 -year -old woman was found to have a tumor shadow on chest X -ray examination during mass screening and was admitted to our hospital. The chest radiograph revealed a round tumor in the right upper lung field. Chest computed tomography (CT) showed a well -defined, 3 -cm -diameter mass in the right upper lobe. The patient underwent a right upper lobectomy under video -assisted thoracoscopic surgery. The postoperative pathological diagnosis was welldifferentiated fetal adenocarcinoma (WDFA), stage IA (pT1bN0M0). The patient was well and free of disease four years after surgery. WDFA is a rare pulmonary neoplasm resembling fetal lung and classified as a variant of adenocarcinoma. WDFA occurs in younger people more often than the other histological types of primary lung cancer. An additional young case of WDFA is reported, along with a review of the relevant literature.

Differences between low and high grade fetal adenocarcinoma of the lung: a clinicopathological and molecular study

“…On the contrary, H-FLAC shows a membranous staining for β-catenin while lacking β-catenin gene mutations (11)(12)(13). FLAC is uncommon, and only a few studies with limited cases on L-FLAC and H-FLAC have been published) (2,4,(7)(8)(9)(10). In the present study, we retrospectively examined 3 L-FLAC cases and 5 H-FLAC cases to provide further information on the clinicopathological and molecular features of FLAC in Chinese patients.…”

“…The pattern resembles the morphology of a developing fetal lung. L-FLAC is characterized by complex glandular structures with low nuclear atypia and prominent morule formation, which resembles the developing fetal lung during the pseudoglandular phase (6)(7)(8)(9). In contrast, H-FLAC shows predominant nuclear atypia while morule formation is rarely observed (2,4,10).…”

Uniportal video-assisted thoracoscopic segmentectomy for fetal adenocarcinoma lung cancer with severe pulmonary emphysema: a case report

“…These clinical symptoms are, therefore, less important now; nevertheless, the clinical patterns of low-grade and high-grade types are different according to previous studies. Low-grade types tend to occur in young people aged 20−50 years, with a mean age of approximately 35 years ( 3 , 9 , 10 ). In contrast, high-grade types occur in older adult patients aged 50−75 years, with a mean age of approximately 65 years.…”