Well-Defined Amphiphilic Thermosensitive Copolymers Based on Poly(ethylene glycol monomethacrylate) and Methyl Methacrylate Prepared by Atom Transfer Radical Polymerization.  Volume 37, Number 14, July 13, 2004, pp 5219−5227.

Ali, Mir Mukkaram; Stöver, Harald D. H.

doi:10.1021/ma0481151

Cited by 9 publications

(6 citation statements)

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“…PEG is an FDA‐approved (FDA = United States Food and Drug Administration) polymer and has therefore been employed extensively in the development of hydrogels,16 dendrimers,17 liposomes,18 micelles,19 nanocapsules20 and nanoparticles21 as therapeutic delivery systems. Over the past few years, a new class of branched PEG with temperature‐responsive properties has attracted research interest in the biomedical field 22–31. Although poly( N ‐isopropylacrylamide) (PNIPAM) has been the most studied temperature‐responsive polymer, protein fouling of PNIPAM, which can lead to shortened circulating half‐lives, is a drawback 32–34.…”

Section: Introductionmentioning

confidence: 99%

Assembly and Degradation of Low‐Fouling Click‐Functionalized Poly(ethylene glycol)‐Based Multilayer Films and Capsules

Leung

Such

Johnston

et al. 2011

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Nano-/micrometer-scaled films and capsules made of low-fouling materials such as poly(ethylene glycol) (PEG) are of interest for drug delivery and tissue engineering applications. Herein, the assembly and degradation of low-fouling, alkyne-functionalized PEG (PEG(Alk) ) multilayer films and capsules, which are prepared by combining layer-by-layer (LbL) assembly and click chemistry, are reported. A nonlinear, temperature-responsive PEG(Alk) is synthesized, and is then used to form hydrogen-bonded multilayers with poly(methacrylic acid) (PMA) at pH 5. The thermoresponsive behavior of PEG(Alk) is exploited to tailor film buildup by adjusting the assembly conditions. Using alkyne-azide click chemistry, PEG(Alk)/PMA multilayers are crosslinked with a bisazide linker that contains a disulfide bond, rendering these films and capsules redox-responsive. At pH 7, by disrupting the hydrogen bonding between the polymers, PEG(Alk) LbL films and PEG(Alk) -based capsules are obtained. These films exhibit specific deconstruction properties under simulated intracellular reducing conditions, but remain stable at physiological pH, suggesting potential applications in controlled drug release. The low-fouling properties of the PEG films are confirmed by incubation with human serum and a blood clot. Additionally, these capsules showed negligible toxicity to human cells.

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Section: Introductionmentioning

confidence: 99%

Assembly and Degradation of Low‐Fouling Click‐Functionalized Poly(ethylene glycol)‐Based Multilayer Films and Capsules

Leung

Such

Johnston

et al. 2011

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“…Poly(ethylene glycol) monomethyl ether methacrylate) (PEGMA), a methacrylate‐based macromonomer with pendent oligo(ethylene oxide) chains, has attracted a considerable attention in recent years as a water‐soluble monomer due to its biocompatibility and low toxicity 1–9. Homopolymers, block copolymers, surface‐grafted polymers, and star polymers10–17 based on PEGMA have been successfully prepared for applications in biology, drug/gene delivery, and synthesis of advanced materials 18, 19…”

Section: Introductionmentioning

confidence: 99%

Upfront observation versus radiation for adult pilocytic astrocytoma

Ishkanian

Laperrière

et al. 2011

Cancer

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BACKGROUND: Although pilocytic astrocytoma accounts for up to 40% of all childhood brain tumors, it is a rare disease in adults. Consequently, there are few mature data on the impact of up-front treatment options after surgery that include observation or adjuvant radiotherapy. METHODS: Ten women and 20 men were identified who were diagnosed with pilocytic astrocytoma from 1971 to 2007 and were retrospectively reviewed. The median patient age was 30 years (range, 18-64 years), and the median follow-up was 87 months (range, 16-420 months). Initial surgery included biopsy (10% of patients), subtotal resection (57% of patients), or gross-total resection (33% of patients). Nineteen patients were observed postoperatively, whereas 11 patients received up-front postoperative adjuvant radiotherapy (50 grays in 25 fractions). No patient received adjuvant or concurrent chemotherapy. Progression-free survival (PFS) and overall survival (OS) were calculated using the Kaplan-Meier method. Differences between survival curves were analyzed with the log-rank test. RESULTS: For the entire cohort, the 5-year and 10-year OS rates were 95% and 85%, respectively, and the 5-year and 10-year PFS rates were 63% and 35%, respectively. The median PFS was 8.4 years. Initial radiation, compared with observation, did not have an impact on OS but significantly improved PFS. The 5-year PFS rate for patients who were observed versus those who received radiation was 42% versus 91%, respectively; and, at 10 years, the PFS rate was 17% versus 60%, respectively (P ¼ .005). Patients who progressed after observation (11 of 19 patients) received various salvage therapies, resulting in a 2-year PFS rate of 68% compared with 33% for patients who progressed after initial radiation (3 of 11 patients) and were salvaged with either chemotherapy or surgery (P ¼ .1). CONCLUSIONS: Adjuvant radiotherapy for pilocytic astrocytoma significantly prolonged PFS at both 5 years and 10 years compared with observation. However, equivalent OS was observed, which reflected the efficacy of salvage therapies. Cancer 2011;117:4070-

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“…We have described earlier the thermal response of a poly(PEGMA) homopolymer,16 copolymers of PEG methacrylate and methyl methacrylate,17 as well as copolymers containing PEG as an H‐bond acceptor, and MAA16 or modified maleic acid18, 19 as H‐bond donors. In the present article, we describe the preparation and thermal properties of copolymers of MAA and different PEG methyl ether methacrylates (PEGMA).…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive copolymers of methacrylic acid and poly(ethylene glycol) methyl ether methacrylate

Jones

Novo

Flagler

et al. 2005

J. Polym. Sci. A Polym. Chem.

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Copolymers of methacrylic acid (MAA) and poly(ethylene glycol) methyl ether methacrylate (PEGMA) were prepared and their cloud points in aqueous solution were studied as a function of comonomer ratio, solution pH, and presence of hydrophobic comonomers. Under acidic conditions, the cloud point falls below 0 °C for copolymers with between 25% to 60% ether content, because of the formation of hydrophobic H‐bonded ether–acid complexes. The cloud point also decreases with solution pH. For equivalent ether to acid ratios, the cloud point decreases with decreasing PEG chain length, because of the presence of a larger number of hydrophobic methyl and methacrylate groups. Similarly, the cloud point decreases upon incorporation of hydrophobic comonomers such as butyl, lauryl, or glycidyl methacrylates. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 6095–6104, 2005

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Well-Defined Amphiphilic Thermosensitive Copolymers Based on Poly(ethylene glycol monomethacrylate) and Methyl Methacrylate Prepared by Atom Transfer Radical Polymerization. Volume 37, Number 14, July 13, 2004, pp 5219−5227.

Abstract: These corrections do not change the interpretation of the results.

Cited by 9 publications

References 0 publications

Assembly and Degradation of Low‐Fouling Click‐Functionalized Poly(ethylene glycol)‐Based Multilayer Films and Capsules

Assembly and Degradation of Low‐Fouling Click‐Functionalized Poly(ethylene glycol)‐Based Multilayer Films and Capsules

Upfront observation versus radiation for adult pilocytic astrocytoma

Thermoresponsive copolymers of methacrylic acid and poly(ethylene glycol) methyl ether methacrylate

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