Well-being in patients with olfactory dysfunction

Mai, Yiling; Menzel, Susanne; Cuevas, Mandy; Haehner, Antje; Hummel, Thomas

doi:10.1016/j.physbeh.2022.113899

Cited by 14 publications

(10 citation statements)

References 31 publications

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“…Olfactory function can have a profound effect on one's overall well‐being. 24 This study used the World Health Organization Well‐Being Index (WHO‐5) for the assessment of subjective well‐being, in which five items are rated using a 6‐point Likert‐type scale ranging from 0 (at no time) to 5 (all the time). 25 The participants were tasked with evaluating the degree to which the five statements resonated with their experiences over the previous 14 days.…”

Section: Methodsmentioning

confidence: 99%

Can immersive olfactory training serve as an alternative treatment for patients with smell dysfunction?

Chao,

Aden,

Göktas

et al. 2024

Laryngoscope Investig Oto

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ObjectivesOlfactory training (OT) has emerged as a first‐line therapeutic approach to the management of olfactory dysfunction. Conventional OT (COT) involves the systematic home‐based exposure to four distinct odors. Previous research has demonstrated that immersive OT (IOT) involving full‐body exposure to dozens of distinct odors could also improve overall olfactory function. This study compared IOT and COT in terms of efficacy.MethodsA total of 60 patients were enrolled and assigned to three groups. The IOT group (n = 25) underwent immersive exposure to 64 odors once daily in a specialized theater. COT participants (n = 17) sniffed four typical odors in a set of four jars twice daily at home. A control group (n = 18) underwent passive observation. Olfactory function was assessed before and after training.ResultsSignificant improvements in composite threshold‐discrimination‐identification (TDI) scores were observed after training in both the IOT (mean difference = 2.5 ± 1.1. p = .030) and COT (mean difference = 4.2 ± 1.3, p = .002) groups. No changes were observed in the control group. A significantly higher proportion of patients in the COT group (41%) presented improvements of clinical importance (TDI ≥5.5) compared to the controls (p = .018). The improvements attained in the IOT group (20%) were less pronounced (p = .38).ConclusionWhile IOT did not exhibit the same efficacy as COT in restoring olfactory function, it still demonstrated promising outcomes. Future efforts to advance olfactory recovery should focus on cross‐modal integration.Level of EvidenceLevel 3.

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Section: Methodsmentioning

confidence: 99%

Can immersive olfactory training serve as an alternative treatment for patients with smell dysfunction?

Chao,

Aden,

Göktas

et al. 2024

Laryngoscope Investig Oto

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“…The sense of smell, although generally underestimated, is crucial for many aspects of everyday life: affecting nutrition and food enjoyment, alerting of potential danger (i.e., poisoned or rotten food, gas leaks; Croy et al, 2014;Stevenson, 2010), and affecting social relationships (Dal Bò et al, 2020;Semin et al, 2019), mood (Delplanque et al, 2017;Kadohisa, 2013), behavior (Cecchetto et al, 2017;Chebat & Michon, 2003), and memory (Herz, 2016;Larsson et al, 2017), all aspects that contribute to the general well-being (Boesveldt & Parma, 2021;Mai et al, 2022). In schizophrenia, olfactory deficits have been repeatedly and consistently documented at different levels (Moberg et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Olfactory Dysfunction in Schizophrenia and Psychotic Disorders: A Comprehensive and Updated Meta-Analysis

Zurlo,

Dal Bò,

Gentili

et al. 2024

Preprint

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Olfaction plays a key role in our daily life, influencing food enjoyment, threat detection,mood and social relationships. Numerous studies have provided evidence of abnormalolfactory function in schizophrenia and other psychotic disorders. This pre-registered meta-analysis was conducted to (a) provide an updated overview on olfactory function inschizophrenia-spectrum disorders, and (b) examine the modulatory effects of demographicand clinical variables on distinct olfactory abilities. We complied with the PRISMAguidelines, searching throughout PubMed and PsycInfo, until the 12th of August 2023. Atotal of 73 publications were included, comprising data from 3282 patients and 3321 healthycontrols. Results revealed that (a) patients performed significantly worse in higher-orderolfactory tasks (identification and discrimination) compared to healthy controls, while nodifferences were observed in odor threshold sensitivity; (b) patients’ performance in odoridentification was moderated by education, as well as disease duration and negativesymptoms. Our findings support the presence of olfactory impairments in schizophrenia-spectrum disorders, leading to significantly poorer performance in both odor identificationand discrimination, but not threshold, when compared to healthy controls.

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“…Olfactory dysfunction (OD) can reduce quality of life, cause depression, and is one of the earliest clinical symptoms of mild cognitive impairment as well as neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease [1] , [2] , [3] , [4] , [5] , [6] , [7] . OD is most commonly contributed to sinonasal disease and upper respiratory tract infections; however, a significant portion of clinical cases are idiopathic in nature [8] .…”

Section: Introductionmentioning

confidence: 99%

Detection of β-N-methylamino-l-alanine in postmortem olfactory bulbs of Alzheimer’s disease patients using UHPLC-MS/MS: An autopsy case-series study

Garamszegi¹,

Banack²,

Duque³

et al. 2023

Toxicology Reports

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Well-being in patients with olfactory dysfunction

Cited by 14 publications

References 31 publications

Can immersive olfactory training serve as an alternative treatment for patients with smell dysfunction?

Can immersive olfactory training serve as an alternative treatment for patients with smell dysfunction?

Olfactory Dysfunction in Schizophrenia and Psychotic Disorders: A Comprehensive and Updated Meta-Analysis

Detection of β-N-methylamino-l-alanine in postmortem olfactory bulbs of Alzheimer’s disease patients using UHPLC-MS/MS: An autopsy case-series study

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