Welfare assessment in porcine biomedical research – Suggestion for an operational tool

Søndergaard, Lene Vammen; Dagnæs‐Hansen, Frederik; Herskin, Mette S.

doi:10.1016/j.rvsc.2011.02.008

Cited by 8 publications

(3 citation statements)

References 107 publications

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“…Pigs are considered to be a suitable animal model for mimicking human diseases and have widely been used in biomedical research [63,64]. e pig joint size, weight requirements, and cartilage thickness are closer to humans than dogs and smaller animal models.…”

Section: Pigmentioning

confidence: 99%

Animal Models of Osteochondral Defect for Testing Biomaterials

Meng

Ziadlou

Grad

et al. 2020

Biochemistry Research International

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The treatment of osteochondral defects (OCD) remains a great challenge in orthopaedics. Tissue engineering holds a good promise for regeneration of OCD. In the light of tissue engineering, it is critical to establish an appropriate animal model to evaluate the degradability, biocompatibility, and interaction of implanted biomaterials with host bone/cartilage tissues for OCD repair in vivo. Currently, model animals that are commonly deployed to create osteochondral lesions range from rats, rabbits, dogs, pigs, goats, and sheep horses to nonhuman primates. It is essential to understand the advantages and disadvantages of each animal model in terms of the accuracy and effectiveness of the experiment. Therefore, this review aims to introduce the common animal models of OCD for testing biomaterials and to discuss their applications in translational research. In addition, we have reviewed surgical protocols for establishing OCD models and biomaterials that promote osteochondral regeneration. For small animals, the non-load-bearing region such as the groove of femoral condyle is commonly chosen for testing degradation, biocompatibility, and interaction of implanted biomaterials with host tissues. For large animals, closer to clinical application, the load-bearing region (medial femoral condyle) is chosen for testing the durability and healing outcome of biomaterials. This review provides an important reference for selecting a suitable animal model for the development of new strategies for osteochondral regeneration.

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Section: Pigmentioning

confidence: 99%

Animal Models of Osteochondral Defect for Testing Biomaterials

Meng

Ziadlou

Grad

et al. 2020

Biochemistry Research International

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“…Domestic pigs (Sus scrofa) are relevant to study because of their close proximity to humans through their use as a food animal, and increasingly (particularly for the smaller breeds) as pets. They are also a commonly used research species, especially in biomedical research [132]. For instance, because of similarities between human and swine cardiovascular systems, pigs are commonly used animals in cardiovascular research [133], and one laboratory research line (the obese Ossabaw pig) has been promoted as a good model for the differential impact of COVID-19 on humans with comorbid obesity [134].…”

Section: The Suidaementioning

confidence: 99%

Animal Transmission of SARS-CoV-2 and the Welfare of Animals during the COVID-19 Pandemic

Ekstrand

Flanagan

Lin

et al. 2021

Animals

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The accelerated pace of research into Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) necessitates periodic summaries of current research. The present paper reviews virus susceptibilities in species with frequent human contact, and factors that are best predictors of virus susceptibility. Species reviewed were those in contact with humans through entertainment, pet, or agricultural trades, and for whom reports (either anecdotal or published) exist regarding the SARS-CoV-2 virus and/or the resulting disease state COVID-19. Available literature was searched using an artificial intelligence (AI)-assisted engine, as well as via common databases, such as Web of Science and Medline. The present review focuses on susceptibility and transmissibility of SARS-CoV-2, and polymorphisms in transmembrane protease serine 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2) that contribute to species differences. Dogs and pigs appear to have low susceptibility, while ferrets, mink, some hamster species, cats, and nonhuman primates (particularly Old World species) have high susceptibility. Precautions may therefore be warranted in interactions with such species, and more selectivity practiced when choosing appropriate species to serve as models for research.

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“…Fortunately, test methods are being developed [ 29 ]. In this line, guides for standardization of sampling protocols [ 276 , 277 ], welfare assessment [ 278 ] and description of protocols to apply human diagnostic tools to pigs (reviewed by [ 28 ]) are available [ 30 ] and should be followed in order to decrease variability and obtain more and better control data. The ongoing development [ 279 ] of universal protocols and good laboratory practice manuals for handling and sampling pigs in translational research will probably increase the acceptance of these guides by the scientific community.…”

Section: Pitfalls Limitations and Unexplored Areas Of The Modelmentioning

confidence: 99%

The Neonatal and Juvenile Pig in Pediatric Drug Discovery and Development

et al. 2020

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Pharmacotherapy in pediatric patients is challenging in view of the maturation of organ systems and processes that affect pharmacokinetics and pharmacodynamics. Especially for the youngest age groups and for pediatric-only indications, neonatal and juvenile animal models can be useful to assess drug safety and to better understand the mechanisms of diseases or conditions. In this respect, the use of neonatal and juvenile pigs in the field of pediatric drug discovery and development is promising, although still limited at this point. This review summarizes the comparative postnatal development of pigs and humans and discusses the advantages of the juvenile pig in view of developmental pharmacology, pediatric diseases, drug discovery and drug safety testing. Furthermore, limitations and unexplored aspects of this large animal model are covered. At this point in time, the potential of the neonatal and juvenile pig as nonclinical safety models for pediatric drug development is underexplored.

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Welfare assessment in porcine biomedical research – Suggestion for an operational tool

Cited by 8 publications

References 107 publications

Animal Models of Osteochondral Defect for Testing Biomaterials

Animal Models of Osteochondral Defect for Testing Biomaterials

Animal Transmission of SARS-CoV-2 and the Welfare of Animals during the COVID-19 Pandemic

The Neonatal and Juvenile Pig in Pediatric Drug Discovery and Development

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