Welcome by Prof. L. Boccon-Gibod

Boccon-Gibod, L

doi:10.1016/s1569-9056(03)80001-5

Cited by 2 publications

(9 citation statements)

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“…Five studies were retrospective cohort studies (LE: 2b) [23][24][25][26][27] , and 5 RCTs (LE: 2a) [14-16, 21, 22] . The methodological quality of these studies was relatively high for one of the RCTs (Jadad scale: 4 of 5 points) [16] and medium for 4 (Jadad scale: 3 of 5 points) [14,15,21,22] . In terms of the 5 non-randomized studies, the quality was relatively high (NOS: 7 of 9 points).…”

Section: Assessment Of Study Qualitymentioning

confidence: 99%

“…Ten relevant studies [14][15][16][21][22][23][24][25][26][27] were selected for analysis including 1,022 patients in total (521 treated with dutasteride and 501 in the control group). No differences were found in terms of age and the basic physical conditions between the treatment group and control group.…”

Section: Assessment Of Study Qualitymentioning

confidence: 99%

“…With regard to the impact of preoperative dutasteride therapy on blood loss per gram of resected prostate tissue during TURP, 3 trials [14,15,22] including 238 participants (126 in the dutasteride group and 112 in the control group) were recruited in our analysis. One trial [21] was excluded due to the lack of the mean values and SD values.…”

Section: Blood Loss Per Gram Of Resected Prostate Tissuementioning

confidence: 99%

“…Transfusion Rate Five studies [14][15][16]22, 26] including 419 participants (219 in the treatment group and 200 in the control group) reported transfusion intro-and-after TURP. A fixed effects model was chosen because no heterogeneity was found among the trials ( I 2 = 0).…”

Section: Blood Loss Per Gram Of Resected Prostate Tissuementioning

confidence: 99%

“…Two systematic review and meta-analyses conducted by Zong et al [11] and Zhu et al [12] identified that preoperative dutasteride use could not decrease bleeding during TURP. However, only 4 studies [14][15][16][17] about dutasteride were included in their analysis and different reference values were used to classify the intraoperative blood loss. Therefore, it is worth conducting a new systematic review and meta-analysis involving relevant available studies to date to evaluate the efficacy of preoperative dutasteride administration for reducing surgical blood loss and MVD of prostatic stromal and suburethral tissue in BPH patients.…”

mentioning

confidence: 99%

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A Systematic Review and Meta-Analysis of the Effects on Dutasteride Treatment for Reducing Surgical Blood Loss during Transurethral Resection of the Prostate

Ren

Lai²,

Jiang³

et al. 2016

Urol Int

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Objective: This systematic review and meta-analysis were performed to evaluate the efficacy of preoperative dutasteride treatment for reducing surgical blood loss in patients undergoing transurethral resection of the prostate (TURP). Methods: A systematic search was performed from the electronic databases including PubMed, EMBASE, and Cochrane Library by May 2016. We followed the search strategy based on Preferred Reporting Items for Systematic Reviews and Meta-analysis statement when examining the literature. Identified articles were strictly appraised for quality and relevance. Results: Five randomized controlled trials (RCTs) and 5 retrospective cohort studies involving 1,022 patients with benign prostate hyperplasia were analyzed based on the inclusion criteria. Pooled analysis revealed that preoperative treatment with dutasteride had a significantly smaller decrease in hemoglobin (weighted mean difference [WMD] -0.47, 95% CI -0.70 to -0.24, p < 0.0001) and hematocrit levels (WMD -1.03, 95% CI -1.73 to -0.33, p = 0.004); However, no signiﬁcant difference has been found in terms of the total blood loss during TURP and blood loos per gram of resected prostatic tissue, the weight of resected prostate tissue, the microvessel density of the prostate, and the transfusion rate between the dutasteride and the control group. Conclusions: This systematic review and meta-analysis indicate that preoperative treatment with dutasteride could reduce surgical bleeding during TURP, but the findings of this study should be further confirmed by well-designed prospective RCTs with a larger patient series.

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