Weitere experimentell-biologische Untersuchungen zum Schizophrenieproblem

Gamper, Eduard; Kral, Adalbert

doi:10.1007/bf02890910

Cited by 2 publications

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“…Thirty years ago, Lazell and Prince (1929) found that tadpoles of Rana catesbiana died in three days from serum of schizophrenic patients, whereas they were not affected by normal serum. Gamper and Kraal (1934) described experiments which apparently showed that the injection of urine or spinal fluid from schizophrenics in juvenile mice caused a severe general intoxication with a mortality varying from 29.7 per cent to 77 per cent, according to the different subtypes of schizophrenia. Reiter (1938) tried to repeat these experiments, but found, unfortunately without success, that none of the mice died or showed abnormality after being injected with material from severely disturbed schizophrenic patients.…”

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Biochemical aspects of schizophrenia and pharmacodynamic implications.

Minz¹

1960

Chronic Schizophrenia: Explorations in Theory and Treatment.

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A RIGOROUS APPROACH to the study of disease would start with a thorough clinical analysis of a disorder or group of disorders and proceed with the elaboration of an adequate therapy. The history of medicine reveals, however, that this logical procedure has rarely been employed. On the contrary, in many instances a very efficient therapy was found, and then, investigations of the possible underlying mechanisms were undertaken or simply left to physiologists or pharmacologists. This has been the case in the treatment of decompensated heart failures with digitalis, the treatment of pernicious anemia with liver extracts, and that of rheumatic fever with ACTH and cortico-steroids. The malaria therapy in general paresis, the electroshock treatment of involutional depression, and, more recently, the successful administration of Rauwolfia alkaloids and phenothiazine derivatives in schizophrenia are cases in point in the field of psychiatry (Kass and Brown, 1955). None of these often spectacular effects have been elucidated in a satisfactory way, but their mere existence constitutes a considerable stimulus for research.The observation that certain abnormal behavioral reactions can

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confidence: 99%

Biochemical aspects of schizophrenia and pharmacodynamic implications.

Minz¹

1960

Chronic Schizophrenia: Explorations in Theory and Treatment.

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Physiological Effects of Schizophrenic Body Fluids

McGeer

1959

J. ment. sci

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Controversy has raged for over half a century as to whether schizophrenia, the most severe of all mental illnesses, could have an organic basis or whether its origin lay strictly in the psyche. Over the years, physiologists have probed into almost every aspect of the soma in the quest for some abnormality which would account for the schizophrenic syndrome. Many possibilities have been considered, investigated to a degree and then abandoned when definitive answers were not forthcoming. A dominant approach throughout has been the search for some psychotoxic material circulating in schizophrenic body fluids. Activity has been spurred by the recurrent recognition that chemical agents such as the ergot alkaloids, mescaline, bulbocapnine and lysergic acid diethylamide (LSD-25), could induce in normal persons transient mental disturbances similar to those seen in schizophrenia.

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Weitere experimentell-biologische Untersuchungen zum Schizophrenieproblem

Cited by 2 publications

References 2 publications

Biochemical aspects of schizophrenia and pharmacodynamic implications.

Biochemical aspects of schizophrenia and pharmacodynamic implications.

Physiological Effects of Schizophrenic Body Fluids

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