In the most general case of ω-weights, some normed functional spaces X p ω (a, b)(1 ≤ p ≤ ∞) , AC n γ,ω [a, b] and a generalization of the fractional integro-differentiation operator are introduced and analyzed. The boundedness of the ω-weighted fractional operator over X p ω (a, b) is proved. Some theorems and lemmas on the properties of the invertions of the mentioned operator and several representations of functions from AC n γ,ω [a, b] are established. A general ω-weighted Caputo fractional derivative of order α is studied over AC n γ,ω [a, b]. Some representations and other properties of this fractional derivative are proved. Some conclusions are presented.