Weight management in basal-bolus insulin therapy for type 2 diabetes mellitus: The deep south diabetes program

Duane, Josann; Conway, William

doi:10.1016/s1557-0843(08)80020-6

Cited by 2 publications

(4 citation statements)

References 15 publications

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“…• Post hoc analyses of RCTs: 16 [19][20][21]24,26,31,32,[35][36][37]41,43,45,[47][48][49] • Retrospective observational cohort studies: 13 [16][17][18]22,23,28,29,34,38,40,42,44,50 • Prospective observational cohort studies: 5 30,33,39,46,51 • Post hoc analyses of prospective cohort studies: 1 27 • Simulation model: 1 15 • Discrete choice experiment: 1 52 • RCT: 1 25 • Cost Studies…”

Section: Study Design • Glycemic Control Studiesmentioning

confidence: 99%

“…• Percent body fat: 1 21 (Continued) • Percent total weight: 8 16,17,33,34,40,45,48,51 • BMI: 1 42 • Quartiles/Tertiles of weight change: 2 19,41 • Composite outcome with HbA1c: 2 25,26 • Kilograms: 18 15,[22][23][24]27,30,32,[35][36][37][38][39]43,44,46,49,52 • Weight lost vs gained/maintained: 5 20,28,31,47,50 • Weight change pattern: 2 18,29 • Cost Studies • Percent total weight: 5 51,[53][54][55]58 • Weight lost vs gained/maintained: 2 50,56 • BMI: 1 60 • Kilograms: 3 52,57,59 Outcome measures • Glycemic control Studies…”

Section: Weight Change Measures • Glycemic Control Studiesmentioning

confidence: 99%

“…• Composite outcome including HbA1c and weight gain/loss: 5 25,26,28,47,56 • FPG or FBG and HbA1c: 7 19,34,37,38,46,51 • HbA1c: 18 [16][17][18][20][21][22][23]29,30,33,36,[40][41][42][43]46,48,49 • HbA1c as a predictor: 6 15,27,31,35,39,44 • HOMA-IR: 1 30…”

Section: Weight Change Measures • Glycemic Control Studiesmentioning

confidence: 99%

“…• Adjusted means: 2 38,40 • Correlation: 5 30,32,36,43 • Descriptive only: 5 19,22,23,46,50 • Linear regression: 12 21,24,27,28,31,[33][34][35]37,39,41,44 • Logistic regression: 7 18,20,25,26,29,42,45 • Meta-analysis: 3 47,48 • Simulation models: 1 15 • Structural equation modelling: 2 16,17 • Discrete choice: 1 52 • Cost Studies • Linear regression: 6 50,51,[53][54][55][56] • Simulation model: 3 [57][58][59] • Cross-sectional survey: 1 52 • medications vs oral medications plus insulin, noting that the insulin group increased weight upon insulin initiation with a reduction in HbA1c. Watson et al 44 also examined weight gain at insulin initiation, finding weight gain highest in those with poorest cont...…”

Section: Type Of Analysis • Glycemic Control Studiesmentioning

confidence: 99%

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<p>Impact of Weight Change in Adults with Type 2 Diabetes Mellitus: A Literature Review and Critical Analysis</p>

Fridman¹,

Lucas²,

Paprocki³

et al. 2020

CEOR

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Objective: Weight reduction is a key component of diabetes management in adults with type 2 diabetes mellitus (T2DM), yet the benefits of weight loss in T2DM patients have been difficult to quantify. We examined the medical literature regarding the relationships between weight change and 1) glycemic control and 2) cost and resource use. Methods: Systematic searches were conducted in the electronic databases Embase, MEDLINE, and the Cochrane Database of Systematic Reviews to identify publications regarding the impact of weight change on T2DM outcomes from 2007 onward. Identified publications were screened for relevance against predefined eligibility criteria, and methodological approaches and results were extracted. Evidence for the impact of weight change on outcomes was evaluated and used to identify strengths, limitations, and gaps in the current literature. Results: The number of studies meeting eligibility criteria for each outcome was: glycemic control (n=38) and cost and resource use (n=11). The relationship between weight change and glycemic control was dependent on the interplay of multiple factors, eg, the weight loss interventions employed, the antidiabetic medication classes used, the time horizon, and baseline BMI and glycemic control. With respect to cost and resource use, the review indicated that savings were associated with weight loss, and increased costs were associated with weight gain. Conclusion: Studies regarding weight change in T2DM patients demonstrated varying effects on glycemic control and a positive association with costs and resource use, where weight loss was associated with decreased costs and resource use. Future studies may be able to clarify these relationships.

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