Weight Maintenance with Litramine (IQP-G-002AS): A 24-Week Double-Blind, Randomized, Placebo-Controlled Study

Grube, Barbara; Chong, Pee-Win; Alt, Felix; Uebelhack, Ralf

doi:10.1155/2015/953138

Cited by 10 publications

(5 citation statements)

References 23 publications

(24 reference statements)

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“…There were no differences in LBM, though both groups did lose LBM suggesting the fiber may have contributed to increased weight loss in the treatment group but did not effectively offset LBM losses in this study; from the total weight lost, the fiber group lost approximately 50% of LBM while the placebo group lost approximately 36% of LBM showing that the fiber did not offset LBM loss [39]. In a similar study conducted over six months, subjects maintained weight loss, but also lost LBM when compared to controls [33].…”

Section: Dietary Supplements and Body Compositionmentioning

confidence: 94%

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Body Composition Changes in Weight Loss: Strategies and Supplementation for Maintaining Lean Body Mass, a Brief Review

2018

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With over two-thirds (71.6%) of the US adult population either overweight or obese, many strategies have been suggested for weight loss. While many are successful, the weight loss is often accompanied by a loss in lean body mass. This loss in lean body mass has multiple negative health implications. Therefore, weight loss strategies that protect lean body mass are of value. It is challenging to consume a significant caloric deficit while maintaining lean body mass regardless of macronutrient distribution. Therefore, the efficacy of various dietary supplements on body weight and body composition have been a topic of research interest. Chromium picolinate has been shown to improve body composition by maintaining lean body mass. In this paper we review some common weight loss strategies and dietary supplements with a focus on their impact on body composition and compare them to the effect of chromium picolinate.

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Section: Dietary Supplements and Body Compositionmentioning

confidence: 94%

“…While CrP and other dietary supplements all lead to weight loss, a larger percent of the weight lost during these studies comes from a loss in LBM. CrP appears to offer an effective means of improving body composition, as individuals are able to lose their fat, while retaining their muscle [14,31,32,33,34].…”

Section: Figurementioning

confidence: 99%

Body Composition Changes in Weight Loss: Strategies and Supplementation for Maintaining Lean Body Mass, a Brief Review

2018

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“…Another double-blind, randomized, placebo-controlled study in overweight and obese subjects lasting 24 weeks demonstrated that after 24 weeks the number of responders was higher in Litramine ®treated subjects than in placebo individuals. At the end of the study the difference in weight between the groups was 2.2 kg; 92% in the Litramine ® group vs. 25% in controls managed to maintain the weight loss (Grube et al, 2015).…”

Section: Dietary Supplementsmentioning

confidence: 93%

Medical management of obesity in Scandinavia 2016

Tonstad

Rössner²,

Rissanen

et al. 2016

Obesity Medicine

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Background: Preventive efforts with improved diet and more exercise have at best decelerated increasing prevalence of overweight and obesity in Scandinavia, and the complications call for more effective treatments. This review is an overview of dietary supplements, medical devices (for oral use), and pharmacological treatments approved in Scandinavian countries. Interventions: One dietary fibre supplement, glucomannan, may produce a weight loss of 0.8 kg over 3 months, but a recent meta-analysis questioned efficacy. Cactus fig and white bean extracts, oral compounds that increase satiety by a fiber effect in the stomach and inhibit either fat or carbohydrate absorption, result in weight losses of~2e3% over 3e6 months, and are generally well tolerated. The pharmaceutical compound orlistat (a lipase inhibitor) produces weight loss of 1e2% with low-dose (over-the-counter) and 3% with high-dose (prescription), with a long-term reduction in risk of type 2 diabetes (T2D). The GLP-agonist liraglutide enhances satiety and produces weight loss of 5e7% over 6 months to 2 years, reducing comorbidities. A naltrexone/bupropion combination produces 3e5% weight loss, and reduces risk of T2D. A class of sodium-glucose co-transporter type 2 (SGLT2) inhibitor approved for the management of T2D also produces a weight loss (2e4% over 3e6 months) by increased excretion of urinary glucose. Conclusion: The available non-pharmacological agents produce clinically relevant weight loss, but studies are small and adverse effects are not well established. Studies of pharmacological agents that use combinations to assess additive effects on weight loss and maintenance are lacking.

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“…The authors did not observe adverse effects after the ingestion of IQP G-002AS. Following the aforementioned study, the same authors in 2015 [31] conducted another double-blind, randomised study spanning twenty-four weeks. This design involved a cohort of subjects, both male and female volunteers with obesity aged between 18 and 60 years, with a BMI ranging from 25 to 35 kg/m 2 .…”

Section: Linarès Et Al (2007)mentioning

confidence: 99%

Usefulness of Opuntia spp. on the Management of Obesity and Its Metabolic Co-Morbidities

Gómez-García,

Fernández-Quintela,

González

et al. 2024

Nutrients

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The plants of the Opuntia genus mainly grow in arid and semi-arid climates. Although the highest variety of wild species is found in Mexico, Opuntia spp. is widely distributed throughout the world. Extracts of these cacti have been described as important sources of bioactive substances that can have beneficial properties for the prevention and treatment of certain metabolic disorders. The objective of this review is to summarise the presently available knowledge regarding Opuntia ficus-indica (nopal or prickly pear), and some other species (O. streptacantha and O. robusta) on obesity and several metabolic complications. Current data show that Opuntia ficus-indica products used in preclinical studies have a significant capacity to prevent, at least partially, obesity and certain derived co-morbidities. On this subject, the potential beneficial effects of Opuntia are related to a reduction in oxidative stress and inflammation markers. Nevertheless, clinical studies have evidenced that the effects are highly contingent upon the experimental design. Moreover, the bioactive compound composition of nopal extracts has not been reported. As a result, there is a lack of information to elucidate the mechanisms of action responsible for the observed effects. Accordingly, further studies are needed to demonstrate whether Opuntia products can represent an effective tool to prevent and/or manage body weight and some metabolic disorders.

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Weight Maintenance with Litramine (IQP-G-002AS): A 24-Week Double-Blind, Randomized, Placebo-Controlled Study

Cited by 10 publications

References 23 publications

Body Composition Changes in Weight Loss: Strategies and Supplementation for Maintaining Lean Body Mass, a Brief Review

Body Composition Changes in Weight Loss: Strategies and Supplementation for Maintaining Lean Body Mass, a Brief Review

Medical management of obesity in Scandinavia 2016

Usefulness of Opuntia spp. on the Management of Obesity and Its Metabolic Co-Morbidities

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