Weight loss program is associated with decrease α-tocopherol status in obese adults

Hamułka, Jadwiga; Górnicka, Magdalena; Sulich, Agnieszka; Frąckiewicz, Joanna

doi:10.1016/j.clnu.2018.07.011

Cited by 17 publications

(17 citation statements)

References 43 publications

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“…Thirdly, the consecutive 3-day dietary record instead of generally applied non-consecutive ones was used for the assessment of dietary intake. However, the consecutive 3-day method was described in the methodological guide on nutrition research [ 34 ] and is still used in nutritional analyses by other authors [ 56 , 57 , 58 ]. For confirmation of the results obtained, however, using the non-consecutive method on a larger study group of children is advisable, particularly for the micronutrient evaluation.…”

Section: Discussionmentioning

confidence: 99%

Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake

Gajewska¹,

Ambroszkiewicz²,

Klemarczyk³

et al. 2018

IJERPH

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Iron metabolism may be disrupted in obesity, therefore, the present study assessed the iron status, especially ferroportin and hepcidin concentrations, as well as associations between the ferroportin-hepcidin axis and other iron markers in prepubertal obese children. The following were determined: serum ferroportin, hepcidin, ferritin, soluble transferrin receptor (sTfR), iron concentrations and values of hematological parameters as well as the daily dietary intake in 40 obese and 40 normal-weight children. The ferroportin/hepcidin and ferritin/hepcidin ratios were almost two-fold lower in obese children (p = 0.001; p = 0.026, respectively). Similar iron concentrations (13.2 vs. 15.2 µmol/L, p = 0.324), the sTfR/ferritin index (0.033 vs. 0.041, p = 0.384) and values of hematological parameters were found in obese and control groups, respectively. Iron daily intake in the obese children examined was consistent with recommendations. In this group, the ferroportin/hepcidin ratio positively correlated with energy intake (p = 0.012), dietary iron (p = 0.003) and vitamin B12 (p = 0.024). In the multivariate regression model an association between the ferroportin/hepcidin ratio and the sTfR/ferritin index in obese children (β = 0.399, p = 0.017) was found. These associations did not exist in the controls. The results obtained suggest that in obese children with sufficient iron intake, the altered ferroportin-hepcidin axis may occur without signs of iron deficiency or iron deficiency anemia. The role of other micronutrients, besides dietary iron, may also be considered in the iron status of these children.

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Section: Discussionmentioning

confidence: 99%

Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake

Gajewska¹,

Ambroszkiewicz²,

Klemarczyk³

et al. 2018

IJERPH

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“…With regard to the importance of achieving and maintaining optimal body weight in many sports, the necessity for weight loss is a very common situation among athletes [56]. However, this is important to note that attempting to lose weight/fat might be associated with reduced dietary fat intake, which in turn is associated with a decreased alpha-tocopherol status [57]. Of note, according to some cohort studies, there is a positive association between the plasma α:γ-tocopherol ratio and fat-free mass percentage (FFM%) and BMI [58], and the dietary vitamin E intake is associated with greater fat-free mass and (FFM)% mass [59].…”

Section: Supplementation With Vitamin E Alone and Combined With Vitammentioning

confidence: 99%

Antioxidants and Exercise Performance: With a Focus on Vitamin E and C Supplementation

Higgins

Izadi

Kaviani

2020

IJERPH

113

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Antioxidant supplementation, including vitamin E and C supplementation, has recently received recognition among athletes as a possible method for enhancing athletic performance. Increased oxidative stress during exercise results in the production of free radicals, which leads to muscle damage, fatigue, and impaired performance. Despite their negative effects on performance, free radicals may act as signaling molecules enhancing protection against greater physical stress. Current evidence suggests that antioxidant supplementation may impair these adaptations. Apart from athletes training at altitude and those looking for an immediate, short-term performance enhancement, supplementation with vitamin E does not appear to be beneficial. Moreover, the effectiveness of vitamin E and C alone and/or combined on muscle mass and strength have been inconsistent. Given that antioxidant supplements (e.g., vitamin E and C) tend to block anabolic signaling pathways, and thus, impair adaptations to resistance training, special caution should be taken with these supplements. It is recommended that athletes consume a diet rich in fruits and vegetables, which provides vitamins, minerals phytochemicals, and other bioactive compounds to meet the recommended intakes of vitamin E and C.

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“…This may suggest that during a lifestyle intervention a vitamin E deficit may appear in patients losing weight. Geiker et al ( 34 ) and Hamułka et al ( 35 ) observed a lowered alpha-tocopherol status in obese adults after a 6-8 week weight loss intervention. These results, coupled with overweight and low alpha-tocopherol intake, suggest that there is an increased risk of oxidative stress diseases in individuals on a reduced diet.…”

Section: Discussionmentioning

confidence: 98%

Associations Between Antioxidant Vitamin Status, Dietary Intake, and Retinol-binding Protein 4 Levels in Prepubertal Obese Children After 3-month Weight Loss Therapy

Gajewska¹,

Ambroszkiewicz²,

Szamotulska³

et al. 2021

Jcrpe

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Objective: Adiposity is associated with increased oxidative stress, leading to changed fat-soluble vitamin concentrations. The aim of this study was to determine whether weight loss alters fat-soluble vitamin status and whether these alterations are associated with dietary intake, anthropometric parameters and adipokines in obese children. Methods: Vitamin A and E concentrations were measured using high-pressure liquid chromatography in 60 obese children before and after weight loss therapy. Retinol-binding protein 4 (RBP4), leptin, soluble leptin receptor (sOB-R), and high molecular weight adiponectin concentrations were determined by immunoenzymatic assays. Results: The intake of vitamin E was lower in obese children with weight loss after therapy (p=0.038). In this group, an increase was found in the vitamin A/lipids (p=0.022) and the vitamin E/lipids (p=0.008) ratios but due to the reduction in triglyceride levels. In the obese group, changes in vitamin E level were positively correlated with changes in dietary vitamin E (p=0.017) and the leptin/sOB-R ratio (p=0.046). Changes in vitamin A level were positively correlated with changes in dietary vitamin A (p=0.001) and RBP4 concentration (p=0.023). Associations between changes in RBP4 level with the changes in body mass index (BMI) (p=0.011) and total cholesterol concentration (p=0.023) but not with changes in vitamin A concentration were found in the obese after therapy. Conclusion: An increased risk of vitamin E deficiency may occur in children losing weight during lifestyle intervention. Changes in BMI value may influence changes in RBP4 concentrations and consequently the vitamin A status in obese children after therapy.

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Weight loss program is associated with decrease α-tocopherol status in obese adults

Cited by 17 publications

References 43 publications

Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake

Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake

Antioxidants and Exercise Performance: With a Focus on Vitamin E and C Supplementation

Associations Between Antioxidant Vitamin Status, Dietary Intake, and Retinol-binding Protein 4 Levels in Prepubertal Obese Children After 3-month Weight Loss Therapy

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