Weight loss normalizes enhanced expression of the oncogene survivin in visceral adipose tissue and blood leukocytes from individuals with obesity

Izquierdo, Andrea G.; Carreira, Marcos C.; Rodríguez-Carnero, Gemma; Fernández‐Quintela, Alfredo; Sueiro, Aurelio M.; Martinez-Olmos, Miguel A.; Guzmán, Germán; Luis, Daniel Antonio de; Pinhel, Marcela Augusta Souza; Nicoletti, Carolina Ferreira; Nonino, Carla Barbosa; Ortega, Francisco; Portillo, Marı́a P.; Fernández‐Real, José Manuel; Casanueva, Felipe F.; Crujeiras, Ana B.

doi:10.1038/s41366-020-0630-7

Cited by 7 publications

(9 citation statements)

References 43 publications

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“…reported that survivin protein expression in human adipocyte-derived stem cells (hASCs) isolated from obese individuals is significantly elevated, which protects hASCs from apoptosis [ 20 ]. Another study reported that survivin expression in visceral adipose tissue is higher in obese animal models than in lean controls, and it decreases after weight loss via energy restriction [ 21 ]. Our previous work has revealed that survivin expression in mature adipocytes from WAT could be highly induced by long-term HFD feeding in vivo [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Survivin is essential for thermogenic program and metabolic homeostasis in mice

Alimujiang

Sun

Chen

et al. 2022

Molecular Metabolism

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Section: Introductionmentioning

confidence: 99%

Survivin is essential for thermogenic program and metabolic homeostasis in mice

Alimujiang

Sun

Chen

et al. 2022

Molecular Metabolism

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“…The expression of ACE2 in PBMCs samples from transversal and a longitudinal cohorts of patients was measured as published 34 . Differential expression of the ACE2 gene was quantified based on the obesity status with respect to normal weight.…”

Section: Methodsmentioning

confidence: 99%

“…The expression of ACE2 in PBMCs samples from transversal and a longitudinal cohorts of patients was measured as published. 34 Differential expression of the ACE2 gene was quantified based on the obesity status with respect to normal weight. In addition, expression data were quantified in obese patients undergoing weight loss intervention using a VLCKD (PnK method ® ).…”

Section: Data Collection and Gene Expression Assessmentmentioning

confidence: 99%

Adipose tissue and blood leukocytes ACE2 DNA methylation in obesity and after weight loss

Izquierdo

Carreira

Boughanem

et al. 2021

Eur J Clin Investigation

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Background: Obesity was consistently associated with a poor prognosis in patients with COVID-19. Epigenetic mechanisms were proposed as the link between obesity and comorbidities risk.Aim: To evaluate the methylation levels of angiotensin-converting enzyme 2 (ACE2) gene, the main entry receptor of SARS-CoV-2, in different depots of adipose tissue (AT) and leukocytes (PBMCs) in obesity and after weight loss therapy based on a very-low-calorie ketogenic diet (VLCKD), a balanced hypocaloric diet (HCD) or bariatric surgery (BS).

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“…On the other hand, survivin is an oncogene expressed in most tumors. Thus, survivin is the direct molecular link between obese adipose and tumors [ 55 ].…”

Section: Main Textmentioning

confidence: 99%

Mammalian tumor-like organs. 2. Mammalian adipose has many tumor features and obesity is a tumor-like process

Kozlov

2022

Infect Agents Cancer

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Background In previous publications, the author developed the theory of carcino-evo-devo, which predicts that evolutionarily novel organs should recapitulate some features of tumors in their development. Main text Mammalian adipose is currently recognized as a multi-depot metabolic and endocrine organ consisting of several adipose tissues. Although lipid-storing cells and proteins are ancient, the adipose organ as a whole is evolutionarily novel to mammals. The adipose expansion has remarkable similarities with the growth of solid tumors. These similarities are the following: (1) The capability to unlimited expansion; (2) Reversible plasticity; (3) Induction of angiogenesis; (4) Chronic inflammation; (5) Remodeling and disfunction; (6) Systemic influence on the organism; (7) Hormone production; (8) Production of miRNAs that influence other tissues; (9) Immunosuppression; (10) DNA damage and resistance to apoptosis; (11) Destructive infiltration in other organs and tissues. These similarities include the majority of “hallmarks of cancer”. In addition, lipomas are the most frequent soft tissue tumors, and similar drugs may be used for the treatment of obesity and cancer by preventing infiltration. This raises the possibility that obesity, at least in part, may represent an oncological problem. The existing similarities between adipose and tumors suggest the possible evolutionary origin of mammalian adipose from some ancestral benign mesenchymal hereditary tumors. Indeed, using a transgenic inducible zebrafish tumor model, we described many genes, which originated in fish and were expressed in fish tumors. Their human orthologs LEP, NOTCH1, SPRY1, PPARG, ID2, and CIDEA acquired functions connected with the adipose organ. They are also involved in tumor development in humans. Conclusion If the hypothesis of the evolutionary origin of the adipose organ from the ancestral hereditary tumor is correct, it may open new opportunities to resolve the oncological problem and the problem of the obesity epidemic. New interventions targeting LEP, NOTCH1, SPRY1, PPARG, ID2, and CIDEA gene network, in addition to what already is going on, can be designed for treatment and prevention of both obesity and tumors.

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Weight loss normalizes enhanced expression of the oncogene survivin in visceral adipose tissue and blood leukocytes from individuals with obesity

Cited by 7 publications

References 43 publications

Survivin is essential for thermogenic program and metabolic homeostasis in mice

Survivin is essential for thermogenic program and metabolic homeostasis in mice

Adipose tissue and blood leukocytes ACE2 DNA methylation in obesity and after weight loss

Mammalian tumor-like organs. 2. Mammalian adipose has many tumor features and obesity is a tumor-like process

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