Weight Loss‐Induced Calciphylaxis: Potential Role of Matrix Metalloproteinases

Reisenauer, Amy K.; Moses, Marsha A.; Kilroy, Susan; Arbiser, Jack L.

doi:10.1111/j.1346-8138.2003.tb00348.x

Cited by 31 publications

(25 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diabetes (26), chemotherapy-induced (cyclophosphamide, Adriamycin, and fluorouracil) protein C and S deficiency (18), Crohn disease (3), POEMS syndrome (12), vitamin D deficiency (10), weight loss (25), chronic kidney disease (not ESKD) (32), and osteomalacia treated with nadroparin calcium (8) were the remaining reported etiologic conditions. In 22 cases, corticosteroid use was an associated predisposing factor (3,6,7,12,13,20,21,23,28,30,33), warfarin use was reported in nine cases (5,6,31), albumin or blood transfusions were reported in seven cases (4,9,(12)(13)(14)(15)19), and protein C or S deficiency was reported in four cases (9,16,18,20).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Calciphylaxis from Nonuremic Causes

Nigwekar

Wolf²,

Sterns

et al. 2008

Clinical Journal of the American Society of Nephrology

370

396

View full text Add to dashboard Cite

Background and objectives: Calciphylaxis, or calcific uremic arteriolopathy, is a well-described entity in end-stage kidney disease and renal transplant patients; however, little systematic information is available on calciphylaxis from nonuremic causes. This systematic review was designed to characterize etiologies, clinical features, laboratory abnormalities, and prognosis of nonuremic calciphylaxis.Design, setting, participants, & measurements: A systematic review of literature for case reports and case series of nonuremic calciphylaxis was performed. Cases included met the operational definition of nonuremic calciphylaxis-histopathologic diagnosis of calciphylaxis in the absence of end-stage kidney disease, renal transplantation, or acute kidney injury requiring renal replacement therapy.Results: We found 36 cases (75% women, 63% Caucasian, aged 15 to 82 yr) of nonuremic calciphylaxis. Primary hyperparathyroidism, malignancy, alcoholic liver disease, and connective tissue disease were the most common reported causes. Preceding corticosteroid use was reported for 61% patients. Protein C and S deficiencies were seen in 11% of patients. Skin lesions were morphologically similar to calcific uremic arteriolopathy. Mortality rate was 52%, with sepsis being the leading cause of death.Conclusion: Calciphylaxis should be considered while evaluating skin lesions in patients with predisposing conditions even in the absence of end-stage kidney disease and renal transplantation. Nonuremic calciphylaxis is reported most often in white women. Mineral abnormalities that are invoked as potential causes in calcific uremic arteriolopathy are often absent, suggesting that heterogeneous mechanisms may contribute to its pathogenesis. Nonuremic calciphylaxis is associated with high mortality, and there is no known effective treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

“…These included 27 individual case reports (3,5,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(27)(28)(29)(30)(31)(32) and four case series (4,6,26,33). A summary of the literature search strategy is provided in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Calciphylaxis from Nonuremic Causes

Nigwekar

Wolf²,

Sterns

et al. 2008

Clinical Journal of the American Society of Nephrology

370

396

View full text Add to dashboard Cite

show abstract

“…[22][23][24][25][26][27][28][29][30][31][32][33] Suspicion of calciphylaxis in nontraditional patients is generally low, as evidenced by the proportion of the reported cases in which accurate diagnosis was delayed. 23,24,[28][29][30] Analysis of these 13 nontraditional cases in addition to the current report showed a mean age of 54.5 years, a preponderance of female patients (female to male ratio, 12:2), and a mortality rate of 43%.…”

Section: Commentmentioning

confidence: 99%

Calciphylaxis With Normal Renal and Parathyroid Function

Kalajian¹,

Malhotra²,

Callen³

et al. 2009

Arch Dermatol

105

View full text Add to dashboard Cite

Background: Calciphylaxis is a life-threatening form of metastatic calcification-induced microvascular occlusion syndrome. Although traditionally observed in patients with end-stage renal disease and/or hyperparathyroidism, the development of calciphylaxis in "nontraditional" patients having both normal renal and parathyroid function has been reported. However, to date there has been no collective analysis identifying common patient characteristics potentially predisposing to the development of calciphylaxis in nontraditional patients.Observations: A 58-year-old woman with endometrial carcinoma developed extensive calciphylaxis despite the presence of normal renal and parathyroid function. The disease resolved with rapid diagnosis, supportive therapy, and medical management. Analysis of this case and the 13 previously reported cases of nontraditional calciphylaxis identified the following patient characteristics that highlight clinical situations potentially predisposing to calciphylaxis: hypoalbuminemia, malignant neoplasm, systemic corticosteroid use, anticoagulation with warfarin sodium or phenprocoumon, chemotherapy, systemic inflammation, hepatic cirrhosis, protein C or S deficiency, obesity, rapid weight loss, and infection.Conclusions: Calciphylaxis is becoming increasingly common in patients with normal renal and parathyroid function. The observations from this study may assist dermatologists in the rapid diagnosis and prompt initiation of therapy for this devastating disease.

show abstract

“…Although kidney disease is also a feature in calciphylaxis, those patients are more likely to present with end-stage renal disease. Moreover, calciphylaxis typically presents with purple-coloured mottling of the skin with the occasional appearance of blood-filled blisters, which were absent in this case [8]. In addition, the histopathology did not support a diagnosis of calciphylaxis in this case.…”

Section: Discussionmentioning

confidence: 81%

Painful Leg Ulceration in a Poorly Controlled Hypertensive Patient: A Case Report of Martorell Ulcer

et al. 2017

View full text Add to dashboard Cite

Martorell ulcer is a form of lower limb ulceration, preceded by a small area of excruciating pain. It often appears as a solitary lesion on the outer aspect of the lower limb, and is primarily associated with poorly controlled hypertension and diabetes. Treatment of the ulcer involves awareness and early correct diagnosis, adequate control of blood pressure, management of infection, and wound care. We describe a 77-year-old diabetic and hypertensive woman presenting with excruciating pain in her right lower lateral leg leading to a necrotic ulcer. Serial photographs of the evolution of the lesion and eventual healing of the ulcer are presented.

show abstract

Weight Loss‐Induced Calciphylaxis: Potential Role of Matrix Metalloproteinases

Cited by 31 publications

References 16 publications

Calciphylaxis from Nonuremic Causes

Calciphylaxis from Nonuremic Causes

Calciphylaxis With Normal Renal and Parathyroid Function

Painful Leg Ulceration in a Poorly Controlled Hypertensive Patient: A Case Report of Martorell Ulcer

Contact Info

Product

Resources

About