Weight Loss Induced by Roux-en-Y Gastric Bypass But Not Laparoscopic Adjustable Gastric Banding Increases Circulating Bile Acids

Kohli, Rohit; Bradley, David; Setchell, Kenneth D.R.; Eagon, J. Christopher; Abumrad, Nada A.; Klein, Samuel

doi:10.1210/jc.2012-3736

Cited by 249 publications

(193 citation statements)

References 18 publications

Supporting

Mentioning

171

Contrasting

Unclassified

Order By: Relevance

“…Most short-term studies (< 2 months after surgery) report unchanged or decreased levels of total BAs [26][27][28], while most studies reporting data from several months and years after surgery report increased concentrations [18,20,[29][30][31][32]. Our findings are in accordance with the existent literature, and extend the current knowledge by showing that the BA levels apparently continue to increase up to 5 years after RYGB.…”

Section: Discussionsupporting

confidence: 91%

“…These observations must be considered as explorative and no conclusions about a causal relationship between these variables and bile acid concentrations can be done. As in several other studies, we were not able to demonstrate any correlation between BAs and markers of glucose metabolism and insulin resistance [18,20,27,28]. We found large variations in fasting BA concentrations both within and between individuals, as depicted in Figure 1.…”

Section: Discussionsupporting

confidence: 49%

“…Most studies report increased BA concentrations after RYGB [16,17], but studies exploring changes in BA fractions are inconsistent [18][19][20]. There are, to our knowledge, no reports of changes in BA profiles after BPD/DS, and there are no reports on BA profiles long term after bariatric surgery.…”

Section: Introductionmentioning

confidence: 96%

See 2 more Smart Citations

Bile acid profiles over 5 years after gastric bypass and duodenal switch: results from a randomized clinical trial

Risstad

Kristinsson

Fagerland

et al. 2017

Surgery for Obesity and Related Diseases

View full text Add to dashboard Cite

(2017). Bile acid profiles over 5 years following gastric bypass and duodenal switch -Results from a randomized clinical trial. Surgery for obesity and related diseases. https://doi.org/10.1016/j.soard.2017.05.024Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rightsCopyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights.•Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research.•You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policy If you believe that this document breaches copyright please contact librarypure@kcl.ac.uk providing details, and we will remove access to the work immediately and investigate your claim. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 49%

See 1 more Smart Citation

Bile acid profiles over 5 years after gastric bypass and duodenal switch: results from a randomized clinical trial

Risstad

Kristinsson

Fagerland

et al. 2017

Surgery for Obesity and Related Diseases

View full text Add to dashboard Cite

show abstract

“…The effect of Roux en Y bypass surgery on bile acid metabolism in normal and obese diabetic rats has recently been published [36] . This study was instigated following the reports that Roux en Y is associated with an increase in bile acids [37][38][39][40][41] . The authors investigated both a rat diabetic model (Zucker diabetic rat) and normoglycaemic Sprague Dawley rats.…”

Section: Effect Of Bile Acids On Lipid and Glucose Metabolismmentioning

confidence: 99%

Obesity diabetes and the role of bile acids in metabolism

Tomkin

Owens

2016

Journal of Translational Internal Medicine

View full text Add to dashboard Cite

Bile acids have many activities over and above their primary function in aiding absorption of fat and fat soluble vitamins. Bile acids are synthesized from cholesterol, and thus are involved in cholesterol homeostasis. Bile acids stimulate glucagon-like peptide 1 (GLP1) production in the distal small bowel and colon, stimulating insulin secretion, and therefore, are involved in carbohydrate and fat metabolism. Bile acids through their insulin sensitising effect play a part in insulin resistance and type 2 diabetes. Bile acid metabolism is altered in obesity and diabetes. Both dietary restriction and weight loss due to bariatric surgery, alter the lipid carbohydrate and bile acid metabolism. Recent research suggests that the forkhead transcription factor FOXO is a central regulator of bile, lipid, and carbohydrate metabolism, but conflicting studies mean that our understanding of the complexity is not yet complete.

show abstract

“…51 Inhibiting postprandial gut hormone responses with octreotide normalized RYGB-induced reduction of appetite and food intake at least in the short term. 51 Besides the L-cell hormones GLP-1 and PYY, other gut hormones and secreted factors such as neurotensin, 57 CCK, 58 ApoA-IV, 59 FGF 15/19 60 and bile acids [61][62][63][64] have been shown to be increased after RYGB and may thus be involved in mediating some of the beneficial effects of bariatric surgeries. The beneficial effects of sleeve gastrectomy have been demonstrated to require FXR signaling, an important target of bile acids.…”

Section: Potential Underlying Mechanisms For Change In Set Pointmentioning

confidence: 99%

Does gastric bypass surgery change body weight set point?

et al. 2016

View full text Add to dashboard Cite

The relatively stable body weight during adulthood is attributed to a homeostatic regulatory mechanism residing in the brain which uses feedback from the body to control energy intake and expenditure. This mechanism guarantees that if perturbed up or down by design, body weight will return to pre-perturbation levels, defined as the defended level or set point. The fact that weight re-gain is common after dieting suggests that obese subjects defend a higher level of body weight. Thus, the set point for body weight is flexible and likely determined by the complex interaction of genetic, epigenetic and environmental factors. Unlike dieting, bariatric surgery does a much better job in producing sustained suppression of food intake and body weight, and an intensive search for the underlying mechanisms has started. Although one explanation for this lasting effect of particularly Roux-en-Y gastric bypass surgery (RYGB) is simple physical restriction due to the invasive surgery, a more exciting explanation is that the surgery physiologically reprograms the body weight defense mechanism. In this non-systematic review, we present behavioral evidence from our own and other studies that defended body weight is lowered after RYGB and sleeve gastrectomy. After these surgeries, rodents return to their preferred lower body weight if over-or underfed for a period of time, and the ability to drastically increase food intake during the anabolic phase strongly argues against the physical restriction hypothesis. However, the underlying mechanisms remain obscure. Although the mechanism involves central leptin and melanocortin signaling pathways, other peripheral signals such as gut hormones and their neural effector pathways likely contribute. Future research using both targeted and non-targeted 'omics' techniques in both humans and rodents as well as modern, genetically targeted, neuronal manipulation techniques in rodents will be necessary.

show abstract

Weight Loss Induced by Roux-en-Y Gastric Bypass But Not Laparoscopic Adjustable Gastric Banding Increases Circulating Bile Acids

Abstract: Compared with LAGB, RYGB increases circulating BAs and TGR5 signaling, but this increase in BAs is not a significant predictor of changes in glucose homeostasis or energy metabolism.

Cited by 249 publications

References 18 publications

Bile acid profiles over 5 years after gastric bypass and duodenal switch: results from a randomized clinical trial

Bile acid profiles over 5 years after gastric bypass and duodenal switch: results from a randomized clinical trial

Obesity diabetes and the role of bile acids in metabolism

Does gastric bypass surgery change body weight set point?

Contact Info

Product

Resources

About