Weight loss in obese girls with polycystic ovarian syndrome is associated with a decrease in Anti‐Muellerian Hormone concentrations

Reinehr, Thomas; Kulle, Alexandra; Rothermel, Juliane; Knop, Caroline; Lass, Nina; Bosse, Christina; Holterhus, Paul‐Martin

doi:10.1111/cen.13358

Cited by 26 publications

(29 citation statements)

References 39 publications

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“…Median, Adolescence: Lee, Lashen, Anderson, Pinola, Elchuri, Cui, Hart, Hernandez and Yetim . Mean, Adolescence: Lee, Elchuri, Cui, Akin, Kim, Reinehr and Sophor…”

Section: Resultsmentioning

confidence: 99%

“…Twenty‐five studies reported serum AMH levels between 10 and 18 years Only five studies reported serum inhibin levels, and only three reported AFC in adolescence . Following a transient decrease at puberty as detailed above, a broad consensus across studies show constant levels of serum AMH during adolescence.…”

Section: Resultsmentioning

confidence: 99%

“…Data were included from 13 studies for a pooled estimate. The weighted median for serum AMH from 10 to 18 years was 26.32 pmol/L (3.68 ng/mL) (data pooled from studies by Lee, Lashen, Anderson, Pinola, Elchuri, Cui, Hart, Hernandez and Yetim) with the weighted mean being 31.84 pmol/L (4.46 ng/mL) (data pooled from studies from Lee, Elchuri, Cui, Akin, Kim, Reinehr, and Sophor(Table ). The weighted median for serum inhibin from 10 to 18 years was 53.86 pg/mL (data pooled from studies by Hagen, Lashen, Akar, and Yetim) .…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-five studies reported serum AMH levels between 10 and 18 years [16][17][18][19][20][22][23][24][25]29,31,[34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] Only five studies reported serum inhibin levels, 23,24,37,45,49 and only three reported AFC in adolescence. 23 16 Cui, 20 Lashen, 24 Lem, 27 Korkmaz 12 and Sahin.…”

Section: Adolescencementioning

confidence: 99%

“…18 In contrast to previous citations, a continuing slight increase in levels throughout adolescence was reported by Cui (r = 0.18, P < 0.01) and Elchuri (r = 0.12, P < 0.001). 19,20 16,19,20,39,42,46,47 (Table 2). The weighted median for serum inhibin from 10 to 18 years was 53.86 pg/mL (data pooled from studies by Hagen, Lashen, Akar, and Yetim).…”

Section: Adolescencementioning

confidence: 99%

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Biomarkers of ovarian reserve in childhood and adolescence: A systematic review

Bhide

Pundir

Homburg

et al. 2019

Acta Obstet Gynecol Scand

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Introduction Certain medical disorders as well as their management may affect gonadal function. Recent advances in the management of these conditions accompanied by the availability and success of methods of fertility preservation has highlighted the need for assessment of ovarian reserve in childhood and adolescence. Serum anti‐Mullerian hormone (AMH) and antral follicle count are well established markers of ovarian reserve and serum inhibin has also been used. However, literature on reference ranges for ovarian reserve markers in this age‐group is relatively scarce. Thus, our aim was to evaluate published data to estimate reference values of ovarian reserve makers in childhood and adolescence. Material and methods We performed a systematic review of the literature reporting ovarian reserve markers in childhood and adolescence. We included only those studies examining markers of ovarian reserve in the normal healthy population between the ages of 0 and 19 years. PROSPERO registration: CRD42018119064. Results Serum AMH emerged as the most common biomarker assessed. Serum AMH was detectable at birth and, after a transient increase in infancy, increased steadily in childhood. Following a slight decrease at puberty, levels were constant throughout adolescence with a peak in adolescence or early adulthood. The mean serum AMH values during infancy, childhood and adolescence were 10.55, 22.32 and 31.84 pmol/L, respectively. The corresponding median values were 9.85, 24.49 and 26.32 pmol/L. It was not possible to construct age‐specific reference intervals because of methodological heterogeneity, variations in the assay used to measure AMH and differing interval width for age used in included studies. Serum inhibin showed an increase from childhood to adolescence, with median serum inhibin values of 53.86 pg/mL in adolescence. Antral follicle count showed a significant positive correlation with serum AMH and a median value of 30.52 in adolescence. Conclusions We summarize the trends and levels of biomarkers of ovarian reserve from birth until young adulthood. Peak levels of serum AMH are reported in adolescence or early adulthood. We have reported median/mean values for serum AMH in different age‐groups based on data pooled from several studies, which may be used as a reference when evaluating ovarian reserve in childhood and adolescence especially when considering fertility preservation.

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“…Median, Adolescence: Lee, Lashen, Anderson, Pinola, Elchuri, Cui, Hart, Hernandez and Yetim . Mean, Adolescence: Lee, Elchuri, Cui, Akin, Kim, Reinehr and Sophor…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%