Weight loss in nintedanib-treated patients with idiopathic pulmonary fibrosis

Tomioka, Haruaki; Iwabayashi, Masaaki; Yokota, Makoto; Hashimoto, Rika; Amimoto, Hisanori

doi:10.1016/j.pupt.2023.102213

Cited by 4 publications

(1 citation statement)

References 39 publications

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“…Thus, the efficacy of nintedanib in patients with PPFE remains controversial. Importantly, we suggest that nintedanib administration be considered only if maintenance of good physique in the patient is assumed because lower weight tends to be associated with weight loss, which is a common side effect of nintedanib, and nintedanib itself (and not ILD alone) may accelerate weight loss as an adverse event, thus leading to its early discontinuation [53,88]. Because long-term persistent use of nintedanib may lead to a favorable prognosis, maintenance of good physique is of major importance when considering that decreased BMI is related to disease progression in patients with PPFE [16].…”

Section: Proposed Management Algorithm For Ppfementioning

confidence: 99%

Proposed Clinical Algorithm for Pleuroparenchymal Fibroelastosis (PPFE)

Yamakawa,

Oda,

Sugino

et al. 2024

JCM

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Pleuroparenchymal fibroelastosis (PPFE) is characterized by fibrosis involving the pleura and subpleural lung parenchyma, predominantly in the upper lobes. As PPFE appears to occur in patients with heterogeneous etiologies, the disease course is thus also heterogenous, with some patients showing rapid progression while others have slow progression. Therefore, it is very difficult to predict prognosis with PPFE. Needless to say, this problematic matter has influenced the treatment strategy of PPFE patients. In fact, until now no evidence has been shown for use in creating an appropriate management algorithm for PPFE. We speculate that “uncoordinated breathing” is the most important reason for dyspnea in PPFE patients. Because monitoring of physique and not just pulmonary function and radiological evaluation is also very important, particularly in PPFE patients, this review focused on the characteristics of PPFE through an overview of previous studies in this field, and we proposed an algorithm as precision medicine based on the current evidence. Multiple views by the pulmonologist are needed to standardize a clinical algorithm that is necessary to correctly assess PPFE patients under the premise of maintenance of physique by providing appropriate nutritional care and pulmonary rehabilitation.

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Section: Proposed Management Algorithm For Ppfementioning

confidence: 99%