Weight loss as treatment for knee osteoarthritis symptoms in obese patients: 1-year results from a randomised controlled trial

Bliddal, Henning; Leeds, Anthony; Stigsgaard, Lise; Astrup, Arne; Christensen, Robin

doi:10.1136/ard.2010.142018

Cited by 112 publications

(147 citation statements)

References 28 publications

Supporting

Mentioning

132

Contrasting

Unclassified

Order By: Relevance

“…In trials among subjects with and without established knee OA, weight loss was shown to have advantageous structure-modifying, systemic, and clinical effects (15)(16)(17)(18)(19)(20)(21). In a systematic review on the effects of weight loss on knee OA patients, a weight loss of at least 5% of body weight was indicated for symptomatic relief (22).…”

Section: Introductionmentioning

confidence: 99%

Prevention of Incident Knee Osteoarthritis by Moderate Weight Loss in Overweight and Obese Females

Runhaar

Vos

Middelkoop

et al. 2016

Arthritis Care & Research

View full text Add to dashboard Cite

Objective. This study evaluated the effect of moderate weight loss on the incidence of knee osteoarthritis (OA) in middle-aged overweight and obese women, without clinical and radiologic knee OA at baseline. Methods. A total of 353 women (87%) with followup data available were selected from the Prevention of Knee Osteoarthritis in Overweight Females study, which evaluated the preventive effect of a diet and exercise intervention and of oral glucosamine sulfate on the incidence of knee OA. This was an exploratory proof-of-concept analysis, which compared the incidence of knee OA between women who reached the clinically relevant weight loss target of 5 kg or 5% of body weight after 30 months and those who did not reach this target. Results. The weight loss group showed a significantly lower incidence of knee OA according to the primary outcome measure, which was composed of the American College of Rheumatology criteria (clinical and radiographic), Kellgren/Lawrence grade ‡2, and joint space narrowing ‡1.0 mm (15% versus 20%; odds ratio 0.5, 95% confidence interval 0.3-0.9). Moreover, the weight loss also positively affected several health measures, such as blood glucose level, body fat percentage, and blood pressure. Conclusion. A reduction of ‡5 kg or 5% of body weight over a 30-month period reduces the risk for the onset of radiographic knee OA in middle-aged overweight and obese women. Because of the slow progression of the disease, a longer followup period will be necessary before the number of prevented cases of knee OA by moderate weight loss becomes clinically more relevant.

show abstract

Section: Introductionmentioning

confidence: 99%

Prevention of Incident Knee Osteoarthritis by Moderate Weight Loss in Overweight and Obese Females

Runhaar

Vos

Middelkoop

et al. 2016

Arthritis Care & Research

View full text Add to dashboard Cite

show abstract

“…рисунок). Это указывает на особую роль гена СЖК и нарушения процесса синтеза жирных ки-слот в ускорении разрушения суставного хряща и, в осо-бенности, в развитии болевого синдрома [16,17], приводя-щих к необходимости эндопротезирования.…”

Section: результатыunclassified

“…Кроме того, пальмитоирование мембранных бел-ков блокирует пролиферативную активность клеток [33]. Возможно, именно это нарушение метаболизма является критическим для активного разрушения хряща, а также для развития болевого синдрома у больных ОА [16,17] на поздней стадии заболевания. Эти данные также указывают на то, что повышение экспрессии СЖК может служить до-полнительным диагностическим признаком ускоренного разрушения суставов у больных ОА.…”

Section: результатыunclassified

IMPAIRED REGULATORY MECHANISMS OF THE mTOR SIGNALING PATHWAY IN OSTEOARTHROSIS

Четина¹,

Bratygina²,

Зайцева³

et al. 2012

rsp

View full text Add to dashboard Cite

“…Despite this it is frequently recommended for the treatment of OA. In a study by Bliddal et al [88] reported at 1 year patients allocated to a low fat high carbohydrate and protein diet had reduced pain in the knee due to OA. This result and others indicate that approximately 30% of obese patients with knee OA can achieve significant long term weight loss and improve their pain symptoms.…”

Section: Weight Lossmentioning

confidence: 99%