Weight loss and waist reduction is associated with improvement in gastroesophageal disease reflux symptoms: A longitudinal study of 15 295 subjects undergoing health checkups

Park, S.-K.; Lee, T.; Yang, Hyo‐Joon; Park, J. H.; Sohn, Chong Il; Ryu, Seungho; Park, D. I.

doi:10.1111/nmo.13009

Cited by 36 publications

(32 citation statements)

References 31 publications

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“…Compared with the NF group, body weight was significantly reduced in the IFR group from the 38th to 50th week of life (p \ 0.05), with around 19.2 and 22.5% loss of the body weight (Fig. 2a), respectively, consistent with the previous reports in mammalian species, including humans (Harvie et al 2011;Jeong et al 2016;Manzanero et al 2014;Park et al 2016). However, body length of the fishes in the groups showed little difference during the periods (Fig.…”

Section: Ifr Causes Body Weight Losssupporting

confidence: 91%

Intermittent food restriction initiated late in life prolongs lifespan and retards the onset of age-related markers in the annual fish Nothobranchius guentheri

Wang

Zhou

et al. 2017

Biogerontology

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Two of the most studied and widely accepted conjectures on possible aging mechanisms are the oxidative stress hypothesis and the insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) pathway. Intermittent fasting (IF) is known to modulate aging and to prolong lifespan in a variety of organisms, but the mechanisms are still under debate. In this study, we first demonstrated that late-onset two consecutive days a week fasting, a form of IF, termed intermittent food restriction (IFR), exhibited a time-dependent effect, and long-term late-onset IFR extended the mean lifespan and maximum lifespan by approximately 3.5 and 3 weeks, respectively, in the annual fish Nothobranchius guentheri. We also showed that IFR reduced the accumulation of lipofuscin in the gills and the protein oxidation and lipid peroxidation levels in the muscles. Moreover, IFR was able to enhance the activities of antioxidant enzymes catalase, glutathione peroxidase, and superoxide dismutase in the fish. Finally, IFR was also able to decelerate the decrease of SirT1 and Foxo3A, but accelerate the decrease of IGF-1. Collectively, our findings suggest that late-onset IFR can retard the onset of age-related markers, and prolong the lifespan of the aging fish, via a synergistic action of an anti-oxidant system and the IIS pathway. It also proposes that the combined assessment of anti-oxidant system and IIS pathway will contribute to providing a more comprehensive view of anti-aging process.

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Section: Ifr Causes Body Weight Losssupporting

confidence: 91%

Intermittent food restriction initiated late in life prolongs lifespan and retards the onset of age-related markers in the annual fish Nothobranchius guentheri

Wang

Zhou

et al. 2017

Biogerontology

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“…21 Another large retrospective study, with more than 15,000 patients, showed an association between improvement in GERD symptoms and reduction in body mass index (BMI) in obese patients who lost at least 2 kg/m 2 in BMI (odds ratio 2.34). 22 Diet, smoking cessation, alcohol moderation. Numerous studies have aimed to fi nd foods that exacerbate refl ux symptoms.…”

Section: Lifestyle Modifi Cationsmentioning

confidence: 99%

GERD: A practical approach

Young

Kumar²,

Thota

2020

CCJM

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“…[5][6][7] Although many studies have investigated the association between obesity and GERD, these studies have been cross-sectional or case-control studies or meta-analyses of cross-sectional or case-control studies. [5][6][7][8] Recently, follow-up studies evaluated the relationship between weight change and GERD, [9][10][11][12][13][14][15][16] and some of them used endoscopy for GERD. [12][13][14][15][16] Erosive esophagitis (EE) is a complication of GERD that can be easily detected via endoscopy and used as an objective criterion for the diagnosis of GERD.…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7][8] Recently, follow-up studies evaluated the relationship between weight change and GERD, [9][10][11][12][13][14][15][16] and some of them used endoscopy for GERD. [12][13][14][15][16] Erosive esophagitis (EE) is a complication of GERD that can be easily detected via endoscopy and used as an objective criterion for the diagnosis of GERD. 1) However, studies exploring the development of EE stratified by weight change are rare.…”

Section: Introductionmentioning

confidence: 99%

Effect of Weight Changes on the Development of Erosive Esophagitis

et al. 2020

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Background: Gastroesophageal reflux disease is highly prevalent among overweight and obese individuals. This study aimed to investigate the effect of weight change on the development of erosive esophagitis (EE). Methods: A retrospective review of medical records from a university hospital in South Korea identified 7,123 subjects who underwent routine health checkups in 2012 and 2014. We excluded participants with EE in 2012. Body mass index (BMI) changes were classified as loss, stable, mild gain, or moderate gain. Results: Mild and moderate weight gain increased the odds of EE development (odds ratio [OR], 1.39; 95% confidence interval [CI], 1.06-1.84 and OR, 2.80; 95% CI, 1.87-4.21, respectively) relative to weight stability. Weight loss decreased the odds of EE development (OR, 0.58; 95% CI, 0.38-0.90) relative to weight stability. After stratifying subjects into three groups by baseline BMI, those with mild and moderate weight gain in the obese group and moderate gain in the overweight group showed increased odds of EE development relative to members of those groups whose weights remained stable (OR, 2.08; 95% CI, 1.29-3.36; OR, 3.92; 95% CI, 1.99-7.73 in obese group, and OR, 3.30; 95% CI, 1.64-6.64 in overweight group, respectively). In comparison, weight loss in the normal weight group decreased the odds of EE development relative to weight stability (OR, 0.38; 95% CI, 0.15-0.97). Conclusion: Weight gain was positively associated with EE development in overweight or obese individuals. Weight loss was negatively associated with EE development in normal-weight individuals.

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Weight loss and waist reduction is associated with improvement in gastroesophageal disease reflux symptoms: A longitudinal study of 15 295 subjects undergoing health checkups

Abstract: Weight loss or waist reduction was associated with improvement in GERD symptoms only in subjects with general or abdominal obesity. Weight loss or waist reduction will be an important treatment option in obese patients.

Cited by 36 publications

References 31 publications

Intermittent food restriction initiated late in life prolongs lifespan and retards the onset of age-related markers in the annual fish Nothobranchius guentheri

Intermittent food restriction initiated late in life prolongs lifespan and retards the onset of age-related markers in the annual fish Nothobranchius guentheri

GERD: A practical approach

Effect of Weight Changes on the Development of Erosive Esophagitis

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