Weight Loss and the Dexamethasone Suppression Test

Kline, Mark D.; Beeber, Alan R.

doi:10.1001/archpsyc.1983.01790080116019

Cited by 35 publications

(6 citation statements)

References 5 publications

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“…Loss of appetite and weight loss are frequent phenomena in endogenous depressives (Hopkinson, 1981) and are important in the interpretation of abnormal test results in endogenous depressives. Our study has been confirmed by Kline and Beeber (1983); and Zimmermann ef al. (1984).…”

Section: Dst In Psychiatric Illnesses Other Than Depressionsupporting

confidence: 89%

The pitfalls of the dexamethasone suppression test: A biological marker of endogenous depression?

Klein

Berger

1987

Human Psychopharmacology

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In the past few years there have been numerous publications which have stressed the value of the dexamethasone suppression test (DST) as a diagnostic marker of endogenous depression. Our own studies in 333 psychiatric inpatients and 121 healthy subjects did not reveal a differential diagnostic use for the DST. This result is in good agreement with other results in the literature. Our data demonstrate that intervening variables such as severity of illness, weight loss, sleep disturbances, situational stress, drug and alcohol withdrawal, and the pharmacokinetics of dexamethasone have an important influence on DST results, regardless of the diagnostic classification.KEY woms-Dexamethasone suppression test, psychiatric disorders, intervening variables, diagnostic value, dexamethasone plasma level.

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Section: Dst In Psychiatric Illnesses Other Than Depressionsupporting

confidence: 89%

The pitfalls of the dexamethasone suppression test: A biological marker of endogenous depression?

Klein

Berger

1987

Human Psychopharmacology

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“…As DST non-suppression has been associated with weight loss in psychiatric patients (Kline and Beeber, 1983), depressed patients (Berger et al, 1985), obese patients (Edelstein et al, 1983), and normal fasting volunteers (Fichter etal, 1986), our findings clearly suggest that the high incidence of DST abnormalities found in bulimic subjects may be secondary to low weight. According to this, the DST does not appear to be a useful measure to analyse the possible relationship between bulimia and major affective disorder.…”

Section: Resultssupporting

confidence: 56%

The dexamethasone suppression test in bulimic outpatients without major depression

Bailly¹,

Regnaut²,

Parquet³

1992

Eur. psychiatr.

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SummaryRecent studies have examined the effectiveness of the dexamethasone suppression test (DST) in the evaluation of bulimia. In a series of 18 female bulimic outpatients without major depression, 9 (50%) failed to suppress on the DST. No significant difference was found between suppressors and nonsuppressors in personal and family histories of affective disorder, levels of anxious and depressive symptoms, psychoactive substance abuse, and severity of abnormal eating-related behaviours. In contrast, non-suppression was significantly associated with low weight. There is a trend to differentiate non-suppressors from suppressors in the current diagnosis of anorexia nervosa and in past history of anorexia nervosa. Seven patients received fluvoxamine for 8 weeks. Five patients were suppressors and showed a significant decrease in the frequency of their binges while the 2 non-suppressors did not improve. These preliminary results suggest that DST non-suppression might be typical of bulimic patients with anorexia nervosa and that pretreatment DST results might predict the response of bulimic behaviour to treatment with fluvoxamine.

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“…The trend for an association between DST non-suppression and low body weight was related to differences in height as suppressors and non-suppressors had similar Ponderal indices. This is not in harmony with the results of studies in healthy volunteers (Fichter and Pirke, 1983;Edelstein et al, 1983), in depressive patients (Carroll, 1972;Berger et al, 1983;Kline and Beeber, 1983) and in patients with anorexia nervosa (Walsh et al, 1978;Abou-Saleh et al, 1985). One study (McKeith, 1984), however, found no association between DST and weight loss.…”

Section: Discussionmentioning

confidence: 84%

Dexamethasone suppression test in dementia

Abou‐Saleh

Spalding

Kellett

et al. 1987

Int J Geriat Psychiatry

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The performance of the Dexamethasone Suppression Test (DST) was investigated in 60 demented patients including 14 patients admitted to a psychogeriatric assessment ward, 29 electively admitted patients and 17 long‐stay patients in comparison with 37 normal control subjects. It was shown that acutely admitted patients had the highest rate of DST non‐suppression (86%), whilst electively admitted patients had the lowest rate (55%) in comparison with normal controls (11%). In the electively admitted group abnormal DST results and Cortisol Suppression Index and DST non‐suppressors showed depressive signs more frequently than suppressors. There was no association between DST results and age, weight, cognitive, behavioural, cortical dysfunction and degree of cerebral atrophy as determined by CT scan results.

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Weight Loss and the Dexamethasone Suppression Test

Cited by 35 publications

References 5 publications

The pitfalls of the dexamethasone suppression test: A biological marker of endogenous depression?

The pitfalls of the dexamethasone suppression test: A biological marker of endogenous depression?

The dexamethasone suppression test in bulimic outpatients without major depression

Dexamethasone suppression test in dementia

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