Weight loss and calcium intake influence calcium absorption in overweight postmenopausal women

Cifuentes, Mariana; Riedt, Claudia S; Brolin, Robert E.; Field, M. Paul; Sherrell, Robert M.; Shapses, Sue

doi:10.1093/ajcn/80.1.123

Cited by 67 publications

(73 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8) concentrations of the bone resorption marker NTX, there was an overall trend for an increase from baseline mean AE SE values of 15.5 AE 1.2 nmol/L BCE and 37.4 AE 4.1 nmol/L BCE / nmol/L creatine, respectively, in response to diet-induced weight loss. A significant increase only occurred for serum NTX in response to a 2-month dietinduced weight loss intervention, albeit this time point only included one study (80) Qualitative analysis of studies that could not be included in the meta-analysis For the three publications (49,75,81) that were not able to be included quantitatively in this meta-analysis, the findings are broadly consistent with results from the meta-analysis. Svendsen and colleagues (49) placed 50 overweight postmenopausal women on a diet involving MER for 3 months, thereby inducing significant weight loss (-9.5 AE 0.4 kg; p ¼ 0001 versus baseline).…”

Section: Serum and Urinary Ntxsupporting

confidence: 68%

Does Diet-Induced Weight Loss Lead to Bone Loss in Overweight or Obese Adults? A Systematic Review and Meta-Analysis of Clinical Trials

Zibellini

Seimon

Lee

et al. 2015

Journal of Bone and Mineral Research

Self Cite

107

View full text Add to dashboard Cite

Diet-induced weight loss has been suggested to be harmful to bone health. We conducted a systematic review and meta-analysis (using a random-effects model) to quantify the effect of diet-induced weight loss on bone. We included 41 publications involving overweight or obese but otherwise healthy adults who followed a dietary weight-loss intervention. The primary outcomes examined were changes from baseline in total hip, lumbar spine, and total body bone mineral density (BMD), as assessed by dual-energy X-ray absorptiometry (DXA). Secondary outcomes were markers of bone turnover. Diet-induced weight loss was associated with significant decreases of 0.010 to 0.015 g/cm 2 in total hip BMD for interventions of 6, 12, or 24 (but not 3) months' duration (95% confidence intervals [CIs], -0.014 to -0.005, -0.021 to -0.008, and -0.024 to -0.000 g/cm 2 , at 6, 12, and 24 months, respectively). There was, however, no statistically significant effect of diet-induced weight loss on lumbar spine or whole-body BMD for interventions of 3 to 24 months' duration, except for a significant decrease in total body BMD (-0.011 g/cm 2 ; 95% CI, -0.018 to -0.003 g/cm 2 ) after 6 months. Although no statistically significant changes occurred in serum concentrations of N-terminal propeptide of type I procollagen (P1NP), interventions of 2 or 3 months in duration (but not of 6, 12, or 24 months' duration) induced significant increases in serum concentrations of osteocalcin (0.26 nmol/L; 95% CI, 0.13 to 0.39 nmol/L), C-terminal telopeptide of type I collagen (CTX) (4.72 nmol/L; 95% CI, 2.12 to 7.30 nmol/L) or N-terminal telopeptide of type I collagen (NTX) (3.70 nmol/L; 95% CI, 0.90 to 6.50 nmol/L bone collagen equivalents [BCEs]), indicating an early effect of diet-induced weight loss to promote bone breakdown. These data show that in overweight and obese individuals, a single diet-induced weight-loss intervention induces a small decrease in total hip BMD, but not lumbar spine BMD. This decrease is small in comparison to known metabolic benefits of losing excess weight.

show abstract

Section: Serum and Urinary Ntxsupporting

confidence: 68%

Does Diet-Induced Weight Loss Lead to Bone Loss in Overweight or Obese Adults? A Systematic Review and Meta-Analysis of Clinical Trials

Zibellini

Seimon

Lee

et al. 2015

Journal of Bone and Mineral Research

Self Cite

107

View full text Add to dashboard Cite

show abstract

“…Weight loss has previously been shown to result in an increase in bone resorption Cifuentes et al, 2004), especially so in women who undergo severe weight loss due to surgery (Coates et al, 2004;Riedt et al, 2006). In Pb-exposed rats, it was shown that weight loss increased BPb levels and organ Pb concentrations (Han et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Blood lead levels and bone turnover with weight reduction in women

Riedt

Buckley

Brolin

et al. 2008

J Expo Sci Environ Epidemiol

Self Cite

View full text Add to dashboard Cite

High bone turnover states are known to raise blood lead levels (BPb). Caloric restriction will increase bone turnover, yet it remains unknown if weight reduction increases BPb due to mobilization of skeletal stores. We measured whole blood Pb levels ( 206 Pb) by inductively coupled plasma mass spectrometry in 73 women (age 24-75 years; BMI 23-61 kg/m 2 ) before and after 6 months of severe weight loss (S-WL), moderate weight loss (M-WL), or weight maintenance (WM). Baseline BPb levels were relatively low at 0.2-6.0 mg/dl, and directly associated with age (r ¼ 0.49, Po0.0001). After severe WL (À37.4 ± 9.3 kg, n ¼ 17), BPb increased by 2.1 ± 3.9 mg/dl (Po0.05), resulting in BPb levels of 1.3-12.5 mg/dl. M-WL (À5.6 ± 2.7 kg, n ¼ 39) and WM (0.3±1.3 kg, n ¼ 17) did not result in an increase in BPb levels (0.5±3.2 and 0.0±0.7 mg/dl, M-WL and WM, respectively). BPb levels increased more with greater WL (r ¼ 0.24, Po0.05). Bone turnover markers increased only with severe WL and were directly correlated with WL. At baseline, higher calcium intake was associated with lower BPb (r ¼ À0.273, Po0.02), however, this association was no longer present after 6 months. Severe weight reduction in obese women increases skeletal bone mobilization and BPb, but values remain well below levels defined as Pb overexposure.

show abstract

“…On the basis of the time required to detect changes in bone mass, that is, several remodeling cycles, it is possible that differences between the low-and recommended dairy weight-maintenance diets may have been detected after a longer follow-up interval. Alternatively, compensatory changes in calcium absorption and excretion in response to either altered calcium intake (Rafferty and Heaney, 2008) or weight loss per se (Cifuentes et al, 2004) might have reduced differences between the low and recommended dairy diets. Similar to the results of this study, Bowen et al (2004) reported that a high dairy-protein diet (2400 mg Ca 2 þ /day) had no effect on TBBMD during 12 weeks of energy restriction and 4 weeks of energy balance in obese men and women compared with a mixed protein diet (500 mg Ca 2 þ /day).…”

Section: Discussionmentioning

confidence: 99%

Total body bone mineral content and density during weight loss and maintenance on a low- or recommended-dairy weight-maintenance diet in obese men and women

et al. 2010

View full text Add to dashboard Cite

Background: Diets high in either dairy or calcium during moderate weight reduction both prevent loss of bone mineral density (BMD) and suppress bone turnover. The purpose of this study was to determine whether recommended dairy and calcium intakes during weight maintenance favorably affect total body BMD (TBBMD) and bone mineral content (TBBMC) in obese adults. Methods: Obese men (n ¼ 49) and women (n ¼ 64), aged 40.8 ± 0.6 years, underwent 12 weeks of moderate energy restriction (B1200 kcal/day) followed by 24 weeks on either a low or recommended dairy weight maintenance diet. The TBBMC and TBBMD values were measured using dual energy X-ray absorptiometry at baseline, 12, 24 and 36 weeks. Concentrations of calcium, intact parathyroid hormone (iPTH), 25OH and 1,25 (OH) 2 vitamin D in plasma were also measured. Data were analyzed using a two-factor repeated measures analysis of variance. Results: After weight loss, women exhibited a small, but statistically significant, increase in TBBMC (1.17±0.57%), whereas TBBMD increased in the men (1.34 ± 0.28%). The iPTH concentration decreased significantly in all subjects. Despite significantly greater intakes of calcium, vitamin D and protein compared with the recommended dairy diet, there were no treatment-related differences in outcome variables after 24 weeks of weight maintenance. The TBBMC remained unchanged in women during weight stabilization; both TBBMC and TBBMD decreased in men (À1.59±0.51% and À0.70±0.25%, respectively). Conclusions: In summary, results of this study do not provide convincing evidence that moderate weight loss through energy restriction and mild exercise reduces TBBMC in obese men and women. Similarly, a weight-maintenance diet providing the recommended daily servings of dairy does not seem to affect changes in BMC after weight loss.

show abstract

Weight loss and calcium intake influence calcium absorption in overweight postmenopausal women

Cited by 67 publications

References 31 publications

Does Diet-Induced Weight Loss Lead to Bone Loss in Overweight or Obese Adults? A Systematic Review and Meta-Analysis of Clinical Trials

Does Diet-Induced Weight Loss Lead to Bone Loss in Overweight or Obese Adults? A Systematic Review and Meta-Analysis of Clinical Trials

Blood lead levels and bone turnover with weight reduction in women

Total body bone mineral content and density during weight loss and maintenance on a low- or recommended-dairy weight-maintenance diet in obese men and women

Contact Info

Product

Resources

About