Weight history from birth through childhood and youth in relation to adult lung function, in Danish juvenile obese and non-obese men

Bua, Jenny; Prescott, Eva; Schack-Nielsen, Lene; Petersen, Liselotte; Godtfredsen, Nina; Sørensen, T. I. A.; Osler, Merete

doi:10.1038/sj.ijo.0802998

Cited by 17 publications

(18 citation statements)

References 33 publications

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“…Initial longitudinal analyses, using BMI measures obtained when the subjects were aged 9, 12, or 15 years suggested a positive association between childhood BMI and adult lung function. This finding is consistent with the results of a previous study of Danish male army recruits (18) in which BMI at 7 years was positively associated with FEV 1 and FVC 19–40 years later after adjustment for adult overweight (BMI ≥25 kg/m 2 ). However, in the present study adjustment for LBM largely eliminated the positive effect of childhood BMI, suggesting that the positive association between childhood BMI and adult lung function is explained by lean mass rather than fat mass.…”

Section: Discussionsupporting

confidence: 92%

“…However, Bua et al . (18) found no difference in the estimates of the effect of childhood BMI on adult lung function between those identified as juvenile obese ( n = 179) and nonobese ( n = 188) males. We are not aware of any published literature of note on this issue in women.…”

Section: Discussionmentioning

confidence: 93%

“…The low prevalence of childhood obesity in this sample may also have limited our power to estimate the true effect of obesity persisting from childhood to adulthood. However, Bua et al (18) found no difference in the estimates of the effect of childhood BMI on adult lung function between those identified as juvenile obese (n = 179) and nonobese (n = 188) males. We are not aware of any published literature of note on this issue in women.…”

Section: Strengths and Limitationsmentioning

confidence: 97%

“…Most have focused on birth-weight, BMI, and growth in the first few years of life (when most alveolar development occurs) and have, in general, shown positive associations with adult lung function (14)(15)(16)(17). A study of 400 Danish male army recruits also reported that BMI at 7 years was positively associated with adult lung function 19-40 years later, independent of age, height, current BMI, smoking, and education (18).…”

mentioning

confidence: 99%

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Longitudinal Associations of Adiposity With Adult Lung Function in the Childhood Determinants of Adult Health (CDAH) Study

Curry

Blizzard

Schmidt

et al. 2011

Obesity

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Childhood BMI has been reported to be positively associated with adult lung function. The aim of this study was to investigate the effect of childhood BMI on young adult lung function independently of the effects of lean body mass (LBM). Clinical and questionnaire data were collected from 654 young Australian adults (aged 27–36 years), first studied when age 9, 12, or 15 years. Adult lung function was measured by forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC ratio, and the forced expiratory flow in the middle 50% of FVC (FEF25–75). BMI and LBM were derived from anthropometric measures at baseline (1985) and at follow‐up (2004–2006). Multivariable models were used to investigate the effect of age and sex standardized BMI in childhood on adult lung function, before and after adjustment for LBM. Adult adiposity had a strong deleterious effect on lung function, irrespective of childhood BMI, and adjustment for childhood LBM eliminated any apparent beneficial effect of childhood BMI on adult FEV1 or FVC. This suggests that the beneficial effect of increased BMI in childhood on adult FEV1 and FVC observed in previous longitudinal studies is likely to be attributable to greater childhood LBM not adiposity. Obese children who become obese adults can expect to have poorer lung function than those who maintain healthy weight but large deficits in lung function are also likely for healthy weight children who become obese adults. This highlights the importance of lifetime healthy weight maintenance.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 93%

Section: Strengths and Limitationsmentioning

confidence: 97%

mentioning

confidence: 99%

See 2 more Smart Citations

Longitudinal Associations of Adiposity With Adult Lung Function in the Childhood Determinants of Adult Health (CDAH) Study

Curry

Blizzard

Schmidt

et al. 2011

Obesity

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“…Additionally, the investigation revealed BMI after 7 years of age had no effect on systolic blood pressure beyond that of current adult BMI [8]. Results from a study on lung function found that BMI at 7 years of age was positively associated, and that adult BMI was negatively associated, with the measures of forced expiratory volume in one second and forced vital capacity [9].…”

Section: Draftees and Obesitymentioning

confidence: 98%

Obesity research based on the Copenhagen School Health Records Register

Baker¹,

Sørensen²

2011

Scand J Public Health

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Introduction: To summarise key findings from research performed using data from the Copenhagen School Health Records Register over the last 30 years with a main focus on obesity-related research. The register contains computerised anthropometric information on 372,636 schoolchildren from the capital city of Denmark. Additional information on the cohort members has been obtained via linkages with population studies and national registers. Research topics: Studies using data from the register have made important contributions in the areas of the aetiology of obesity, the development of the obesity epidemic, and the long-term health consequences of birth weight as well as body size and growth in childhood. Conclusion: Research using this unique register is ongoing, and its contributions to the study of obesity as well as other topics will continue for years to come.

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Lung function and overweight in school aged children after early childhood wheezing

Sidoroff

Hyvärinen

Piippo-Savolainen

et al. 2010

Pediatric Pulmonology

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Background and purpose Recently, obesity has been connected with wheezing, asthma and reduced lung function. Most previous studies have been cross‐sectional. The aim of the present follow‐up study was to evaluate the association of preceding or current overweight or obesity with lung function at early and late school age after early childhood wheezing. Material and methods From the 100 children hospitalized for infection associated wheezing at <24 months of age, 83 attended the control visit at 4.0 years, 82 at 7.2 years and 81 at 12.3 years of age. Flow‐volume spirometry was performed in 79 children at 7.2 years and in 80 children at 12.3 years of age. The weight status was assessed by calculating body mass index (BMI) at all visits. Age‐ and gender‐specific BMI standard deviation scores (BMI–SDS) of >1.3 SD and >2.0 SD were defined to mean overweight and obesity, respectively. Results Overweight at both 7.2 and 12.3 years of age was associated with decreased FEV1/FVC (forced expiratory volume in 1 sec/forced vital capacity). Overweight and obesity at 7.2 years of age were associated with decreased FEV1/FVC and MEF50 (maximal expiratory flow at 50% of FVC) at 12.3 years of age. The results were similar by continuous and categorized analyses, being robust to adjustments for viral findings during early childhood wheezing and asthma maintenance medication at school age. Conclusion Overweight and obesity are significant risk factors for reduced lung function at school age after early childhood wheezing. Thus, early‐life wheezers should avoid excessive weight gain during childhood. Pediatr. Pulmonol. 2011; 46:435–441. © 2010 Wiley‐Liss, Inc.

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Weight history from birth through childhood and youth in relation to adult lung function, in Danish juvenile obese and non-obese men

Cited by 17 publications

References 33 publications

Longitudinal Associations of Adiposity With Adult Lung Function in the Childhood Determinants of Adult Health (CDAH) Study

Longitudinal Associations of Adiposity With Adult Lung Function in the Childhood Determinants of Adult Health (CDAH) Study

Obesity research based on the Copenhagen School Health Records Register

Lung function and overweight in school aged children after early childhood wheezing

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