Weight gain measured at 6 weeks after birth as a predictor for severe retinopathy of prematurity: study with 317 very low birth weight preterm babies

Filho, João Borges Fortes; Bonomo, Pedro Paulo; Maia, Maurício; Procianoy, Renato S.

doi:10.1007/s00417-008-1012-3

Cited by 83 publications

(54 citation statements)

References 30 publications

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“…Currently, low weight gain after premature birth is widely accepted as a predictive factor for later development of ROP, being considered superior to BW and GA alone as predictors. [12][13][14][15][16][17][18] In addition, ROPScore also takes into account the use of oxygen in mechanical ventilation and the need for blood transfusions. All these risk factors are involved in the process of ROP development and can be easily identified by ophthalmologists during the initial ROP screening eye examination.…”

Section: Discussionmentioning

confidence: 99%

A predictive score for retinopathy of prematurity in very low birth weight preterm infants

Eckert

Filho

Maia

et al. 2011

Eye

104

102

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Aims This study describes the development of a score based on cumulative risk factors for the prediction of severe retinopathy of prematurity (ROP) comparing the performance of the score against the birth weight (BW) and gestational age (GA) in order to predict the onset of ROP. Methods A prospective cohort of preterm infants with BWp1500 g and/or GAp32 weeks was studied. The score was developed based on BW, GA, proportional weight gain from birth to the 6th week of life, use of oxygen in mechanical ventilation, and need for blood transfusions from birth to the 6th week of life. The score was established after linear regression, considering the impact of each variable on the occurrences of any stage and severe ROP. Receiver operating characteristic (ROC) curves were used to determine the best sensitivity and specificity values for the score. All variables were entered into an Excel spreadsheet (Microsoft) for practical use by ophthalmologists during screening sessions. Results The sample included 474 patients. The area under the ROC curve for the score was 0.77 and 0.88 to predict any stage and severe ROP, respectively. These values were significantly higher for the score than for BW (0.71) and GA (0.69) when measured separately. Conclusions ROPScore is an excellent index of neonatal risk factors for ROP, which is easy to record and more accurate than BW and GA to predict any stage ROP or severe ROP in preterm infants. The scoring system is simple enough to be routinely used by ophthalmologists during screening examination for detection of ROP.

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Section: Discussionmentioning

confidence: 99%

A predictive score for retinopathy of prematurity in very low birth weight preterm infants

Eckert

Filho

Maia

et al. 2011

Eye

104

102

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“…This would allow identifying, in a timely manner, babies at risk of developing severe ROP. Fortes Filho et al (17) , in 2009, demonstrated in a prospective study the practical importance of assessing and monitoring WG in the first 6 weeks of life as a predictive factor for later onset of ROP. In that study, it was reported that the occurrence of WG less than 51.2% of BW in the first 6 weeks of life was indicative for the development of severe ROP.…”

Section: Main Risk Factors For Ropmentioning

confidence: 99%

“…In that study, it was reported that the occurrence of WG less than 51.2% of BW in the first 6 weeks of life was indicative for the development of severe ROP. Since assessing and monitoring WG can be easily performed during screening programs for detection of ROP, and especially because it does not add costs to the public health system of developing countries, this procedure would be of paramount importance as a practical clinical tool for ophthalmologists carrying out screening sessions for detection of ROP (17,18) .…”

Section: Main Risk Factors For Ropmentioning

confidence: 99%

Prevention of retinopathy of prematurity

Filho¹,

Eckert²,

Tartarella³

et al. 2011

Arq. Bras. Oftalmol.

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Retinopathy of prematurity (ROP) is related to oxygen-regulated vascular endothelial growth factor and to insulin-like growth factor-I. After premature birth, supplemental oxygen induces a retinal hyperoxic condition with vasoconstriction and to a definitive interruption of retinal vasculogenesis. Peripheral ischemia may stimulate retinal neovascularization and the onset of additional ROP-related complications. The natural course of the disease may result in irreversible blindness if not promptly diagnosed and attended. Recently, a significant increase in the prevalence of ROP has been observed in survival rates of preterm infants, especially in emerging-economy countries in Latin America, Asia, and Eastern Europe. This article addresses the main preventive measures in ROP. Keywords

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“…While degree of prematurity is decisive, oxygen treatment is the most studied risk factor, which, when poorly controlled, still causes blindness in relatively mature preterm babies. 1 Recently, poor weight gain during the first weeks of life has been found to be strongly associated with later ROP development, [2][3][4] indicating that factors causing impaired general growth also have a negative impact on retinal vessel development.…”

mentioning

confidence: 99%

Editorial on ‘Hyperglycemia, insulin and slower growth velocity may increase the risk of retinopathy of prematurity’ Kaempf JW et al.

Hellström

2011

J Perinatol

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Weight gain measured at 6 weeks after birth as a predictor for severe retinopathy of prematurity: study with 317 very low birth weight preterm babies

Abstract: Low WG by six weeks of life is an important and independent risk factor for severe ROP and is capable to predict the development of severe ROP in most patients that needed treatment.

Cited by 83 publications

References 30 publications

A predictive score for retinopathy of prematurity in very low birth weight preterm infants

A predictive score for retinopathy of prematurity in very low birth weight preterm infants

Prevention of retinopathy of prematurity

Editorial on ‘Hyperglycemia, insulin and slower growth velocity may increase the risk of retinopathy of prematurity’ Kaempf JW et al.

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