Weight Gain and Progression to Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus

Moon, Joon Ho; Kwak, Soo Heon; Jung, Hye Seung; Choi, Sung Hee; Lim, Soo; Cho, Young Min; Park, Kyong Soo; Jang, Hak Chul; Cho, Nam H.

doi:10.1210/jc.2015-1113

Cited by 43 publications

(57 citation statements)

References 35 publications

(21 reference statements)

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“…However, this should be carefully interpreted, as individual studies did not distinguish the incidence of early postpartum diabetes (≤ 8 weeks after delivery) from that of late conversion to diabetes but only determined the average incidence after several years of follow-up in each study. Studies from Korea reported that the incidence of early postpartum diabetes (6 to 8 weeks) was higher than 10% [36,45]. This incidence rate (incidence per unit time) during the early postpartum period was much higher than the rate of ~50% of postpartum diabetes in following 5 to 10 years [7].…”

Section: Postpartum Diabetes In Women With Previous Gdmmentioning

confidence: 99%

Section: Risk Factors For Postparum Diabetesmentioning

confidence: 99%

“…For this reason, a prospective cohort study was conducted in Korea by Moon et al [45] which included 418 Korean women with GDM (baseline BMI 23.3 kg/m 2 ). This study demonstrated that subjects in the highest tertile of postpartum BMI change had ~2-fold higher risk of developing diabetes compared with women in the lowest tertile (mean BMI change in each tertile, 1.6 and –1.8 kg/m 2 , respectively) [45]. In this study, postpartum weight gain did not merely affect development of diabetes but was also associated with other metabolic phenotypes, including lipid profile, blood pressure, and dynamic glycemic parameters (e.g., Matsuda and insulinogenic indices) (Fig.…”

Section: Risk Factors For Postparum Diabetesmentioning

confidence: 99%

“…Subjects in the first tertile (who lost weight during follow-up) showed improvements in both insulin sensitivity and insulin secretion, whereas subjects in the third tertile (who gained weight during follow-up) had significant deterioration in insulin sensitivity but were not able to compensate by increasing their insulin secretion during follow-up. Adapted from Moon et al [45], with permission from Endocrine Society.…”

Section: Figurementioning

confidence: 99%

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Prevention of type 2 diabetes mellitus in women with previous gestational diabetes mellitus

Moon

Kwak

Jang

2017

Korean J Intern Med

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Gestational diabetes mellitus (GDM), defined as any degree of glucose intolerance with onset or first recognition during pregnancy, is characterized by underlying maternal defects in the β-cell response to insulin during pregnancy. Women with a previous history of GDM have a greater than 7-fold higher risk of developing postpartum diabetes compared with women without GDM. Various risk factors for postpartum diabetes have been identified, including maternal age, glucose levels in pregnancy, family history of diabetes, pre-pregnancy and postpartum body mass index, dietary patterns, physical activity, and breastfeeding. Genetic studies revealed that GDM shares common genetic variants with type 2 diabetes. A number of lifestyle interventional trials that aimed to ameliorate modifiable risk factors, including diet, exercise, and breastfeeding, succeeded in reducing the incidence of postpartum diabetes, weight retention, and other obesity-related morbidities. The present review summarizes the findings of previous studies on the incidence and risk factors of postpartum diabetes and discusses recent lifestyle interventional trials that attempted to prevent postpartum diabetes.

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Section: Postpartum Diabetes In Women With Previous Gdmmentioning

confidence: 99%

Section: Risk Factors For Postparum Diabetesmentioning

confidence: 99%

Section: Risk Factors For Postparum Diabetesmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Prevention of type 2 diabetes mellitus in women with previous gestational diabetes mellitus

Moon

Kwak

Jang

2017

Korean J Intern Med

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“…The etiology of gestational diabetes mellitus is not well-understood. The pathogenesis of gestational diabetes mellitus involves many complex environmental and lifestyle factors, such as pregnancies at an older age, high pre-pregnancy weight and BMI, hydramnios, a history of gestational diabetes mellitus, a history of type 2 diabetes, vaginal candida infection, and a history of gestational diabetes (Kühl, 1991;Damm, 1998;Kopp, 2005;Anna et al, 2008;Savitz et al, 2008;Sella et al, 2013;Moon et al, 2015). However, not all pregnant women exposed to certain risk factors go on to develop gestational diabetes mellitus, suggesting that hereditary factors may contribute to the occurrence of this disease.…”

Section: Introductionmentioning

confidence: 99%

Effect of GSTM1, GSTT1, and GSTP1 IIe105Val polymorphisms on susceptiblity to gestational diabetes mellitus

2016

Genet. Mol. Res.

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ABSTRACT. We investigate the role of the GSTM1, GSTT1, and GSTP1 IIe105Val genetic polymorphisms in the susceptibility to gestational diabetes mellitus. A total of 223 pregnant women with gestational diabetes mellitus and 265 healthy pregnant women were examined at The Second Affiliated Hospital of Shaanxi University of Chinese Medicine from May 2013 to November 2013. Genotyping for detection of GSTM1, GSTT1, and GSTP1 IIe105Val polymorphisms was conducted using the restriction fragment length polymorphismpolymerase chain reaction. There were statistically significant differences between patients with gestational diabetes mellitus and control subjects in terms of age (c 2 = 6.68, P = 0.01) and BMI (t = 7.56, P < 0.001) levels of HDL-C (t = 2.62, P = 0.005) and LDL-C (t = 3.98, P < 0.001). By the chi-square test, we found significant differences between the present and null genotype distributions of GSTM1 (c 2 = 10.95, P = 0.0009). Null genotype of GSTM1 could influence the susceptibility to gestational diabetes mellitus compared to the present genotype [adjusted OR (95%CI) = 1.85 (1.26-2.72)]. However, the unconditional logistic analysis revealed that GSTT1 and GSTP1 IIe105Val polymorphisms could not influence the risk of gestational diabetes mellitus in a Chinese population. In summary, we suggest that the GSTM1 gene polymorphism could influence the susceptibility to gestational diabetes mellitus in a Chinese population.

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Trends and predictors of gestational diabetes mellitus in Chile

Garmendia

Mondschein

Montiel

et al. 2019

Intl J Gynecology & Obste

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ObjectiveTo examine the temporal trends in gestational diabetes mellitus (GDM) prevalence in Chile, and to determine the main predictors of GDM.MethodsA secondary analysis was conducted of all birth records at Hospital Dr. Sótero del Río, Chile, from January 1, 2002, to December 31, 2015. We excluded those women with pre‐existing type 2 diabetes, those with missing data, and those with unlikely data. GDM was defined as fasting glucose levels >5.55 mmol/L [>100 mg/dL] or >7.77 mmol/L [>140 mg/dL] 2 hours after glucose load in the oral glucose tolerance test. Potential predictors were selected based on prior research and ease of evaluation.ResultsFrom the original database of 100 758 records, 86 362 women were included in the final cohort. The mean GDM prevalence was 7.6% (95% CI [confidence interval] 7.5%–7.8%), increasing from 4.4% (95% CI 4.0%–4.9%) in 2002 to 13.0% (95% CI 12.0%–13.9%) in 2015. Age, education, marital status, parity, family history of type 2 diabetes, personal history of GDM, hypertension and pre‐eclampsia, alcohol consumption, smoking, and pre‐gestational nutritional status performed well in the prediction of GDM.ConclusionOne out of eight Chilean pregnant women of medium‐ to low socio‐economic status were found to develop GDM. We identified a set of easy‐to‐capture predictors in the primary health care system that may allow for the early identification of women at high‐risk for the development of GDM.

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Weight Gain and Progression to Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus

Abstract: Postpartum increase in BMI is significantly associated with a risk of diabetes and deterioration of metabolic phenotypes in Korean GDM women.

Cited by 43 publications

References 35 publications

Prevention of type 2 diabetes mellitus in women with previous gestational diabetes mellitus

Prevention of type 2 diabetes mellitus in women with previous gestational diabetes mellitus

Effect of GSTM1, GSTT1, and GSTP1 IIe105Val polymorphisms on susceptiblity to gestational diabetes mellitus

Trends and predictors of gestational diabetes mellitus in Chile

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