“…This is in agreement with earlier reports, which found a significantly increased weight of the gastrointestinal tract of rats that were treated with lithium (0.14e0.21 mEq/l). 18,19 In studies using another activator of Wnt, Rspo1, an elongation of the intestine and an increase in intestinal weight was observed in female Balb/c mice. 4,5 At the same time, Rspo1 treatment increased the crypt depth of the colon, goblet cell number (both at day 7) 4 and cytosolic b-catenin staining (6 h after injection), 5 indicating active Wnt-signaling, compared to controls.…”