Weight gain after STN-DBS: The role of reward sensitivity and impulsivity

Aiello, Marilena; Eleopra, Roberto; Foroni, Francesco; Rinaldo, Sara; Rumiati, Raffaella I.

doi:10.1016/j.cortex.2017.04.005

Cited by 31 publications

(33 citation statements)

References 62 publications

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“…49 One study reported that patients with at least 1 contact located medially in the STN experienced significantly greater weight gain than those with both active contacts located laterally, suggesting involvement of the limbic system. 49 Aiello and colleagues 50 studied food reward sensitivity (liking, wanting, and preference) and a food "go/no-go" task to examine the impulsivity of patients undergoing STN-DBS before, a few days after, and months following the operation. A few days after surgery, patients demonstrated increased impulsivity in the food go/no-go task, showing a preference for high calorie foods.…”

Section: Reviewmentioning

confidence: 99%

Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease

Bellini

Best

Brechany

et al. 2020

Movement Disord Clin Pract

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Background The role of deep brain stimulation (DBS) in the management of motor symptoms in patients with Parkinson's disease is well defined. However, it is becoming increasingly clear that DBS can either improve or worsen a number of non‐motor phenomena. Objectives We examined the published literature to better understand the effects on autonomic symptoms following DBS of the subthalamic nucleus and the globus pallidus interna. Methods We conducted a PubMed search of studies regarding the effects of DBS on the autonomic system published from January 2001. We searched for the following terms and their combinations: Parkinson's disease, deep brain stimulation, subthalamic nucleus, globus pallidus interna, autonomic dysfunction. Results Most studies reported in the literature focus on DBS targeting the subthalamic nucleus, with particular emphasis on favorable outcomes regarding gastrointestinal function and bladder control. However, the emergence or worsening of autonomic symptoms in subgroups of patients has also been documented. More controversial is the effect of stimulation on the cardiovascular, pulmonary, and thermo‐regulatory systems as well as sexual functioning. Data regarding the influence of DBS on the autonomic system when the target is the globus pallidus interna is less forthcoming, with target selection varying according to centre and clinical indication. Conclusions DBS appears to affect the autonomic nervous system, with varying degrees of influence, which may or may not be clinically beneficial for the patient. A better understanding of these effects could help personalize stimulation for individual patients with autonomic disorders and/or avoid autonomic symptoms in susceptible patients.

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Section: Reviewmentioning

confidence: 99%

Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease

Bellini

Best

Brechany

et al. 2020

Movement Disord Clin Pract

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“…Impulsivity defined as premature responding to stimuli was measured in a total of 130 STN-DBS PD patients (Table 3; Jahanshahi et al, 2000;Dujardin et al, 2001;Schroeder et al, 2002;van den Wildenberg et al, 2006;Page and Jahanshahi, 2007;Ballanger et al, 2009;Hershey et al, 2010;Georgiev et al, 2016;Aiello et al, 2017). An early study (van den Wildenberg et al, 2006) was not able to show a significant difference (P = 0.08) between DBS On and Off conditions when examining rate of NoGo commission errors.…”

Section: Inhibitory Controlmentioning

confidence: 99%

“…Georgiev et al (2016) were unable to confirm higher rates of NoGo commission errors during STN stimulation, and also did not observe increases in premature responding (anticipation errors). One study showed significant impairment in NoGo paradigm response inhibition prior to DBS being switched on (Aiello et al, 2017), but these subjects were evaluated only 5 days post-surgery, making it unclear whether acute postoperative factors contributed to cognitive deficits. Jahanshahi et al (2000) showed a heightened error rate on the Stroop test, which was specific to STN stimulation, being unaffected by globus pallidus interna (GPi) stimulation.…”

Section: Inhibitory Controlmentioning

confidence: 99%

Impulsivity and Compulsivity After Subthalamic Deep Brain Stimulation for Parkinson’s Disease

Scherrer

Smith

Gowatsky

et al. 2020

Front. Behav. Neurosci.

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Impulsivity and compulsivity are prominent non-motor problems in Parkinson's disease (PD). Despite 20 years of research, there is still an ongoing debate as to whether subthalamic deep brain stimulation (STN DBS) for PD exacerbates or improves these symptoms. Here, we review how STN DBS affects clinical symptoms and neurocognitive aspects of impulsivity and compulsivity. When comparing patients post-to pre-surgery, in the majority of studies STN DBS for PD is associated with a decrease in clinically diagnosed impulse-control disorders and disorders of compulsivity. To avoid confounds, such as post-surgical decreases in dopaminergic medication doses, comparisons can also be made between DBS "On" versus "Off" conditions. These experimentally assayed effects of STN DBS with respect to neurocognitive aspects of impulsivity and compulsivity are more mixed. STN DBS improves behavioral flexibility without impairing negative feedback learning, delay discounting, or inhibitory control, as long as stimulation is restricted to the dorsal STN. However, STN DBS may drive impulsive actions when a subject is faced with competing choices. We discuss how motivated responses may be either enhanced or impaired by STN DBS depending on engagement of dorsal or ventral STN-mediated circuits. Future studies should combine structural and functional circuit measures with behavioral testing in PD patients on and off medication and stimulation. A more sophisticated understanding of how to modulate corticostriatal-thalamo-cortical loops will increase the likelihood that these circuit manipulation techniques can successfully be applied to a wider range of neuropsychiatric disorders.

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“…disorders include Parkinson's disease (Aiello et al, 2017;Sauleau et al, 2014) and dementia . Another interesting group of patients could also be patients undergoing gastric bypass surgery for treatment of obesity (Shin and Berthoud, 2011).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Using real-time fMRI brain-computer interfacing to treat eating disorders

Sokunbi

2018

Journal of the Neurological Sciences

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Weight gain after STN-DBS: The role of reward sensitivity and impulsivity

Cited by 31 publications

References 62 publications

Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease

Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease

Impulsivity and Compulsivity After Subthalamic Deep Brain Stimulation for Parkinson’s Disease

Using real-time fMRI brain-computer interfacing to treat eating disorders

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