Weight Gain After Renal Transplantation Is a Risk Factor for Patient and Graft Outcome

El‐Agroudy, Amgad E.; Wafa, Ehab W.; Gheith, Osama; El-Dein, Ahmed B. Shehab; Ghoneim, Mohamed A.

doi:10.1097/01.tp.0000120949.86038.62

Cited by 127 publications

(93 citation statements)

References 20 publications

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“…Recent data from a contemporary cohort of the United Network for Organ Sharing database indicated that 50% of transplant patients could be classified as obese or morbidly obese (20). Obesity can predispose to insulin resistance, diabetes, ischemic heart disease, and reduced graft survival (9, 21,22). Obesity in transplant patients is also being increasingly recognized in the context of the metabolic syndrome, which is defined in Table 2.…”

Section: Obesitymentioning

confidence: 99%

Management of Cardiovascular Disease in Renal Transplant Recipients

Shirali¹,

Bia²

2008

Clinical Journal of the American Society of Nephrology

110

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Cardiovascular disease is a major cause of graft loss and the leading cause of death in renal transplant recipients. Although there are robust data on the frequency of risk factors and their contributions to cardiovascular disease in this population, few trials have demonstrated the benefit of modifying these risk factors to reduce cardiovascular events. Nevertheless, it is widely accepted that the clinical acumen filtered through the best available studies in the general population be used to treat individual renal transplant recipients given their high cardiovascular mortality. Transplant task forces and the Kidney Disease Outcomes Quality Initiative have created guidelines for this purpose. This review examines the data available for prevention and treatment of major risk factors contributing to cardiovascular disease in renal transplant recipients. The contribution of immunosuppressive agents to each risk factor and the evidence to support lifestyle modification as well as drug therapy are examined. Reducing cardiovascular risk factors requires an integrative approach that is best accomplished by a team of health care professionals. It creates a significant challenge but one that must be met if allograft survival is to improve.

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Section: Obesitymentioning

confidence: 99%

Management of Cardiovascular Disease in Renal Transplant Recipients

Shirali¹,

Bia²

2008

Clinical Journal of the American Society of Nephrology

110

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“…13 According to De Oliveira and associates, weight gain after transplant is common and is seen in both patients who were obese and patients who were not obese before transplant. 14 Others have also documented that weight gain often emerges in the first year after transplant 11,15,16 and is a common problem for patients, especially during the first 6 months. Weight gain after transplant has been shown to be from 6 to 10 kg, with average body mass index increasing between 2 and 3.8 kg/m 2 .…”

Section: Resultsmentioning

confidence: 99%

Untitled

2016

Exp Clin Transplant

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Objectives: Weight gain and obesity are frequent problems for renal transplant patients. The purpose of this review is to show why weight gain is experienced by patients after kidney transplant and the significance of prevention. Materials and Methods: To investigate this topic, PubMed and Ulakbim databases were searched with the following key words: renal transplant and transplantation, weight gain, and obesity. Results: Weight gain frequently appears in the first year after transplant, and it is reported to be a common problem for patients within the first 6 months. Weight gain varies between 6 and 10 kg, and the change in mean body mass index varies between 2 and 3.8 kg/m 2 after transplant. Potential factors causing weight gain after kidney transplant are the use of immunosuppressive medications to protect the newly implanted organ and the changes in life style, such as dietary intake and insufficient physical activity. In addition, weight gain is affected by factors such as age, sex, race, lack of acute rejection, genetics, and psychological factors related to stress. Conclusions: A better understanding of food intake, physical activities, and environmental factors causing weight gain after kidney transplant and the development of dietary intake and physical activity protocols specific to individuals would be helpful for health care professionals.

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“…More weight gain has been documented in patients who are moderately obese at the time of transplant than in non-obese patients. 3,56 El-Agroudy and research team 23 documented that weight gain occurred in the first 6 months following transplant and that weight gain tended to increase after that but at a slower rate. They speculated that this weight gain could be attributed to nutritional intake, lessened rates of activity and a higher amount of steroids in their pharmacological protocol.…”

Section: Health Outcomes Of Weight Gain In Healthy Adultsmentioning

confidence: 99%

“…Immunosuppressant medications can also affect body fat distribution and the retention of excess fluid may cause weight gain in the post transplant recipient. 2,23 Significant hyperglycemia and post transplant diabetes are also common side effects of not only corticosteroids, but also seen with other immunosuppressive agents such as cyclosporine and tacrolimus. 24 In addition, cyclosporine, tacrolimus and sirolimus, along with corticosteroids may contribute to the metabolic changes following kidney transplantation as the body is attempting to adjust from its previous state of uremia.…”

Section: List Of Tablesmentioning

confidence: 99%

“…62 As a result of improved appetite 123 following renal transplantation, these individuals are at risk for weight gain leading to obesity. 23 Increased risk for cardiovascular disorders is often attributed to obesity following kidney transplantation, 30 and presently, the leading cause of death following kidney transplantation is cardiovascular disease. 124 Past research has targeted allograft rejection and advances in immunosuppressive medication regimes to preserve the newly transplanted kidney.…”

Section: Introductionmentioning

confidence: 99%

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Characterizing Dietary Intake and Physical Activity Affecting Weight Gain in Kidney Transplant Recipients

Cupples¹

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Weight Gain After Renal Transplantation Is a Risk Factor for Patient and Graft Outcome

Abstract: BMI has a strong association with outcomes after renal transplantation independent of most of the known risk factors for patient and graft survival.

Cited by 127 publications

References 20 publications

Management of Cardiovascular Disease in Renal Transplant Recipients

Management of Cardiovascular Disease in Renal Transplant Recipients

Untitled

Characterizing Dietary Intake and Physical Activity Affecting Weight Gain in Kidney Transplant Recipients

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