Weight Gain After Fecal Microbiota Transplantation

Alang, Neha; Kelly, Colleen R.

doi:10.1093/ofid/ofv004

Cited by 359 publications

(248 citation statements)

References 3 publications

Supporting

Mentioning

225

Contrasting

Unclassified

Order By: Relevance

“…In two isolated incidences, pronounced weight gain and the development of IBS-like symptoms following FMTs were reported. 24 , 25 In an extensive case series, 31 patients had received feces from a donor who later developed Crohn's disease. 26 Fortunately, none of the patients developed clinical sequelae nor microbial signatures of inflammatory bowel disease (IBD).…”

Section: Discussionmentioning

confidence: 99%

Recruitment of feces donors among blood donors: Results from an observational cohort study

et al. 2018

View full text Add to dashboard Cite

As the use of fecal microbiota transplantation (FMT) has gained momentum, an increasing need for continuous access to healthy feces donors has developed. Blood donors constitute a healthy subset of the general population and may serve as an appropriate group for recruitment. In this study, we investigated the suitability of blood donors as feces donors. In a prospective cohort study, we recruited blood donors onsite at a public Danish blood bank. Following their consent, the blood donors underwent a stepwise screening process: First, blood donors completed an electronic pre-screening questionnaire to rule out predisposing risk factors. Second, eligible blood donors had blood and fecal samples examined. Of 155 blood donors asked to participate, 137 (88%) completed the electronic pre-screening questionnaire, 16 declined, and 2 were excluded. Of the 137 donors who completed the questionnaire, 79 (58%) were excluded mainly due to having an allergy, being overweight, or presenting gastrointestinal complaints. Among the remaining 58 (37%) donors, complete blood and feces screenings were obtained from 46 (79%). Of these 46 donors, 15 (33%) were excluded primarily due to abnormal blood results or the presence of apathogenic intestinal parasites. Overall, 31 (20%; 95% confidence interval 14–27%) of the 155 blood donors qualified as feces donors. In conclusion, blood donors constitute a suitable and motivated population for a continuous recruitment of voluntary feces donors. We found that a stepwise recruitment procedure was feasible and that 20% of the blood donors were eligible for feces donation.

show abstract

Section: Discussionmentioning

confidence: 99%

Recruitment of feces donors among blood donors: Results from an observational cohort study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…As shown in animal models, FMT may have the potential to transfer a pathogenic disease state from donor to recipient (55), which may be more significant in the developing Review microbiome (56). Moreover, in adults, the development of autoimmune disease and rapid weight gain has been reported after FMT (57,58). Therefore, the question is raised whether transfer of an adult microbiome to a developing microbiome in a child may predispose to quickening of immune aging and development of immune related complications (59).…”

Section: Special Considerations Precautions and Future Directions Fmentioning

confidence: 99%

Fecal microbiota transplantation in children: a brief review

Hourigan

Oliva-Hemker

2016

Pediatr Res

View full text Add to dashboard Cite

There has been a growing interest in fecal microbiota transplantation (FMT) over recent years, in part due to the increasing prevalence of Clostridium difficile infection (CDI) and expanding association of intestinal dysbiosis with a wide range of human diseases. Many adult studies have shown that FMT is an effective treatment for recurrent CDI and may possibly have applications in other illnesses such as inflammatory bowel disease (IBD); however, there is a paucity of data available in children who may differ from adults for many reasons including having a dynamic developing microbiome compared to adults who have a relatively stable microbiome. Here, we review published studies looking at FMT in children, for CDI and IBD, and discuss special considerations needed when conducting FMT in children.

show abstract

“…Fresh faecal matter is preferably obtained from relatives of the patients immediately before transplantation. A careful donor screening regarding faecal microbiota composition, pathogen status and undesirable antigens and ‘phenotypes’ must be performed preventively (Petrof and Khoruts, 2014; Alang and Kelly, 2015). Despite the increasing demand for FMT, rigorous exclusion criteria for donors strongly limit the widespread availability of suitable faecal material (Konig et al ., 2017).…”

Section: Introductionmentioning

confidence: 99%

Cryopreservation of artificial gut microbiota produced with in vitro fermentation technology

Bircher

Schwab

Geirnaert

et al. 2017

Microbial Biotechnology

View full text Add to dashboard Cite

SummaryInterest in faecal microbiota transplantation (FMT) has increased as therapy for intestinal diseases, but safety issues limit its widespread use. Intestinal fermentation technology (IFT) can produce controlled, diverse and metabolically active ‘artificial’ colonic microbiota as potential alternative to common FMT. However, suitable processing technology to store this artificial microbiota is lacking. In this study, we evaluated the impact of the two cryoprotectives, glycerol (15% v/v) and inulin (5% w/v) alone and in combination, in preserving short‐chain fatty acid formation and recovery of major butyrate‐producing bacteria in three artificial microbiota during cryopreservation for 3 months at −80°C. After 24 h anaerobic fermentation of the preserved microbiota, butyrate and propionate production were maintained when glycerol was used as cryoprotectant, while acetate and butyrate were formed more rapidly with glycerol in combination with inulin. Glycerol supported cryopreservation of the Roseburia spp./Eubacterium rectale group, while inulin improved the recovery of Faecalibacterium prausnitzii. Eubacterium hallii growth was affected minimally by cryopreservation. Our data indicate that butyrate producers, which are key organisms for gut health, can be well preserved with glycerol and inulin during frozen storage. This is of high importance if artificially produced colonic microbiota is considered for therapeutic purposes.

show abstract

Weight Gain After Fecal Microbiota Transplantation

Cited by 359 publications

References 3 publications

Recruitment of feces donors among blood donors: Results from an observational cohort study

Recruitment of feces donors among blood donors: Results from an observational cohort study

Fecal microbiota transplantation in children: a brief review

Cryopreservation of artificial gut microbiota produced with in vitro fermentation technology

Contact Info

Product

Resources

About