Periodic collinear edge hole cracks and arbitrary small cracks emanating from collinear holes, which are two typical multiple site damages occurred in the aircraft structures, are studied by using the weigh function method. An explicit closed form weight function for periodic edge hole cracks in an infinite sheet is obtained and further used to calculate the stress intensity factor and crack opening displacement for various loading cases. Compared to finite element method, the present weight function is accurate and highly efficient. The interactions of the holes and cracks on the stress intensity factor and crack opening displacement are quantitatively determined by using the present weight function. An approximate weight function method is also proposed for arbitrary small cracks emanating from multiple collinear holes. This method is very useful for calculating the stress intensity factor for arbitrary small cracks.