Weight Bearing Joints Destruction In Rheumatoid Arthritis

Imagama, Takashi; Tokushige, Atsunori; Seki, Kazushige; Taguchi, Toshihiko

doi:10.2174/1573397112666160331142548

Cited by 10 publications

(9 citation statements)

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“…RA commonly affects the hip joint and is a potential etiology of end-stage arthrosis [1,4,18]. Imagama, et al reported that RA can lead to joint destruction, decreased activities of daily living, and gait disorder [19]. Often THA is the treatment for those with debilitating hip pain, arthrosis and destruction by RA [6,20].…”

Section: Discussionmentioning

confidence: 99%

Girdlestone Resection Arthroplasty: A Salvage Procedure for Severe Rheumatoid Arthritis

T¹,

S²,

Grant³

et al. 2023

J Orthop Rheumatism

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Surgical intervention for severe manifestations of RA of the hip most commonly consists of implantation of a cementless total hip arthroplasty (THA) [6]. Most current literature supports the use of cementless THA as use of cementless components has shown great outcomes when compared to cemented components [7]. Common surgical challenges faced in patients undergoing THA for RA are poor bone quality and the presence of instability [1,4,8]. Current literature highlights osseous erosions and synovial pannus

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Section: Discussionmentioning

confidence: 99%

Girdlestone Resection Arthroplasty: A Salvage Procedure for Severe Rheumatoid Arthritis

T¹,

S²,

Grant³

et al. 2023

J Orthop Rheumatism

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“…In general, these processes occur in the small joints of the feet and hands but may also occur in larger joints such as the shoulder and knees. [65][66][67][68][69][70] These symptoms are more pronounced after long periods of inactivity, and a conspicuous feature of the disease is increased stiffness in the morning. [71][72][73][74][75] Pain related to RA is caused at the inflammation site and is classified as nociceptive rather than neuropathic.…”

Section: Risk Factors and Symptomsmentioning

confidence: 99%

Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Ding

Wang

et al. 2023

Sig Transduct Target Ther

109

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Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease progression leads to joint deformity and associated loss of function, which significantly impacts the quality of life for sufferers and adds to losses in the labor force. In the past few decades, RA has attracted increased attention from researchers, the abnormal signaling pathways in RA are a very important research field in the diagnosis and treatment of RA, which provides important evidence for understanding this complex disease and developing novel RA-linked intervention targets. The current review intends to provide a comprehensive overview of RA, including a general introduction to the disease, historical events, epidemiology, risk factors, and pathological process, highlight the primary research progress of the disease and various signaling pathways and molecular mechanisms, including genetic factors, epigenetic factors, summarize the most recent developments in identifying novel signaling pathways in RA and new inhibitors for treating RA. therapeutic interventions including approved drugs, clinical drugs, pre-clinical drugs, and cutting-edge therapeutic technologies. These developments will hopefully drive progress in new strategically targeted therapies and hope to provide novel ideas for RA treatment options in the future.

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“…In contrast to patients with osteoarthritis with impairment of one knee, rheumatics involve several joints of the lower extremities in the disease process. Pain and arthritic changes in the pelvis and ipsilateral hip lead to changes in the kinematics of the knee joint, as do deformities of the hindfoot as a result of posticus insufficiency [29][30][31][32]. The supposedly well-intentioned protection impairs the overall mobility of patients in the long term.…”

Section: Biomechanics and Clinic Of The Rheumatic Kneementioning

confidence: 99%

Biomechanical Particularities in the Therapy of the Rheumatic Knee

et al. 2020

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In rheumatoid arthritis, the joints of the lower extremities are almost always affected. This is most conspicuous in the knee joint. In rheumatics, inflammatory osteoarthritis manifests itself comparably earlier than in patients with osteoarthritis. The focus of attention was primarily on the synovia with its destruction process and secondary changes. Now, driven by experimental research, dendritic cells and fibroblasts and molecular features are moving into the clinician’s field of vision. Even in joints that appear to be in remission with no swelling or pain, the activity of these cells leads to changes in the capsule-ligaments. The complex deformities and instabilities caused by this, in conjunction with atrophy of the inter-articular musculature, have an impact on the activities of daily life (ADL). If these biomechanical aspects of the knee joint are not taken into account early on in therapy, the frequency of primary and secondary surgical treatment increases. The timely recognition of biomechanical pathologies and consistent treatment can contribute to improving the patient situation in addition to adequate medication therapy.

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Weight Bearing Joints Destruction In Rheumatoid Arthritis

Cited by 10 publications

References 0 publications

Girdlestone Resection Arthroplasty: A Salvage Procedure for Severe Rheumatoid Arthritis

Girdlestone Resection Arthroplasty: A Salvage Procedure for Severe Rheumatoid Arthritis

Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Biomechanical Particularities in the Therapy of the Rheumatic Knee

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