Weierning, a Chinese patent medicine, improves chronic atrophic gastritis with intestinal metaplasia

Integrated Approaches Revealed the Therapeutic Mechanisms of Zuojin Pill Against Gastric Mucosa Injury in a Rat Model with Chronic Atrophic Gastritis

“…Then, the TUNEL staining was used to evaluate the apoptosis rate as described previously. 5 The apoptosis of cells was observed under light microscope, and the results were expressed by the average number of TUNEL positive staining cells per 200× magnification.…”

“… 3 Previous studies have shown that CAG is caused by a combination of factors, including helicobacter pylori infection, inadequate immune regulation and impaired energy metabolism, and that its pathogenesis is related to oxidative stress, inflammation, endothelial and mucosal dysfunction. 4 , 5 The current clinical treatment of CAG relies mainly on the agents used for gastric mucosal protection and symptom relief, vitamin C supplementation and proton pump inhibitors, which limit their clinical application due to their long course, aggressiveness and side effects. 6 , 7 Therefore, there is an urgent need for complementary and alternative treatments for CAG.…”

Research on the signaling pathway and the related mechanism of traditional Chinese medicine intervention in chronic gastritis of the “inflammation-cancer transformation”

“…Weierning, a Chinese patent medicine, was found to decrease the serum IL-1β level and mRNA expression of inflammatory factors, including IL-6 and IL-8, in gastric tissues of the CAG rat model. This significantly reduced collagen deposition in the gastric mucosa submucosa, slowing down the apoptosis of gastric mucosal epithelial cells and, therefore, maintaining the integrity of the gastric mucosal barrier ( Han et al, 2023 ). It also decreases the protein expression of Cdx2, Muc2, Shh, Gli1, and Smo to hinder the Hh pathway, and reverses the intestinal metaplasia of the gastric mucosa to hinder the advancement of mucosal atrophic degeneration.…”

Granule Dendrobii suppresses chronic atrophic gastritis induced by N-methyl-N'-nitro-N-nitrosoguanidine by modulating the gastrointestinal bacteria in rats

“…During CAG, pathological changes occur in the gastric mucosal layer, causing thinning, disappearance, or thickening of the mucosal base due to atrophy of the gastric mucosal glands. It is often accompanied by inflammation and precancerous lesions, such as intestinal metaplasia (IM) and dysplasia (1)(2)(3). The progression from normal tissue to gastric cancer (GC) involves five processes: normal gastric mucosa, CAG, IM, dysplasia, and GC (4).…”