Wegener's granulomatosis of the breast: a rare entity with daily clinical relevance

Allende, Daniela S.; Booth, Christine N.

doi:10.1016/j.anndiagpath.2009.04.005

Cited by 48 publications

(44 citation statements)

References 24 publications

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“…A study of 27 cases over 30 years showed that only 33% of cases had breast symptoms as an initial presentation. 9 The diagnosis of IGM heavily relies on biopsy showing central necrosis and necrotizing granulomatous inflammation with classic vasculitic changes. Treatment includes immunosuppressant such as corticosteroids and cyclophosphamide.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous Mastitis in a Hispanic Woman

Wankhedkar

Chaudhari²,

Xiong³

et al. 2016

American Journal of Therapeutics

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A 33-year-old mother of 2 healthy children presented with bilateral recurrent breast infections despite successful treatment of each episode of an infection. With a negative rheumatologic medical history as well as a negative review of systems, she continued to have these infections frequently. Hence, a breast biopsy was performed after the treatment with a course of antimicrobials, which revealed changes suggestive of granulomatous mastitis. She was started on methotrexate (MTX) with a good response. But, due to persistent nodularity, corticosteroids were added to the regimen with MTX dose escalation. Patient remained disease free thereafter without any adverse effects.

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Section: Discussionmentioning

confidence: 99%

Granulomatous Mastitis in a Hispanic Woman

Wankhedkar

Chaudhari²,

Xiong³

et al. 2016

American Journal of Therapeutics

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“…Serological studies include p-ANCA, c-ANCA, and the recently introduced PR-3 ANCA ELISA 38 39. In an extensive series of breast WG reported over the last 3 decades, most cases have systemic manifestations as well as serological/histological findings in which the histology revealed vasculitis of small-sized to medium-sized vessels in conjunction with granuloma 40. Other vasculitides that have been reported in the in the breast are polyarteritis nodosa and giant cell arteritis, with small-sized to medium-sized blood vessels being affected from a lymphocytic infiltrates within the external or internal elastic lamina or adventitia to a more pronounced destruction of the vessel wall with thrombosis and multinucleated giant cells 41.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous mastitis: the histological differentials

Lacambra

Thai²,

Lam³

et al. 2011

J Clin Pathol

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“…Breast tissue involvement in the course of Wegener’s granulomatosis occurs very rarely, as reflected in the literature [4,5]. In 2009, Allende and Booth performed a review of the English-language literature containing 28 patients with breast involvement in the course of Wegener’s granulomatosis [6]. That same year, Dimitropoulos et al reported another case [6,7].…”

Section: Discussionmentioning

confidence: 99%

Wegener’s granulomatosis of the breast: A case report

Szabo-Moskal¹

2014

Pol J Radiol

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SummaryBackgroundDifferential diagnosis and detection of malignant lesions in mammography poses a challenge for many diagnosticians. Although mammography continues to be the best and cost-effective way to detect breast cancer, it has its limitations due in part to the radiological appearance of changes of a very rare condition. We are presented with changes that have met well-known radiologic criteria for the diagnosis of malignancy, yet they turn out to be benign, because they belong to a group of extraordinary lesions.Case ReportIn June 2010, a 56-year-old woman found a lump in her right breast. Mammography performed at another medical center, revealed a change 12 mm in diameter, rated as BI-RADS 4C. Physical examination revealed a palpable lesion, 15 mm in diameter. Ultrasonography revealed hypoechogenic change with ill-defined outlines, size 14×10 mm – BI-RADS 5. Fine needle aspiration biopsy was done and revealed no atypical cells. The patient underwent an open surgical biopsy and a histopathological diagnosis was suggested to be a type of Wegener’s granulomatosis. Exclusion of cancer enabled the continuation of medical treatment of the underlying disease. There were no changes in the breast in follow-up studies.ConclusionsThe differential diagnosis of breast tumors should include rare conditions that can sometimes mimic breast cancer. One of them is Wegener’s granulomatosis. Both, the diagnosis and treatment of the disease, require the cooperation of specialists from various fields, including clinicians, pathologists and radiologists.

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Wegener's granulomatosis of the breast: a rare entity with daily clinical relevance

Cited by 48 publications

References 24 publications

Granulomatous Mastitis in a Hispanic Woman

Granulomatous Mastitis in a Hispanic Woman

Granulomatous mastitis: the histological differentials

Wegener’s granulomatosis of the breast: A case report

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