Wegener's granulomatosis involving the urogenital tract

Giant cell arteritis involving the testis was identified incidentally upon orchidectomy of a right testicular mass. The mass looked like a malignant process on ultrasound. The patient also had generalised disease and was treated appropriately. Giant cell arteritis involving the bladder, prostate, uterus, and adnexa have been described before. To our knowledge, this is the first described case of giant cell arteritis affecting the testis.

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“…Vasculitis aecting the urogenital tract has been described but is uncommon [1,2,3,4]. The most common cause is polyarteritis nodosa [1].…”

Section: Discussionmentioning

confidence: 99%

Giant cell arteritis mimicking a testicular tumour

Sundaram

Smith

2001

Rheumatology International

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“…57 Urogenital involvement that includes lesions of the penis, urethra, testis, and female and male bladders has been reported. 61 Spleen and breast lesions have also been reported tract. 62 Approximately, 40% of WG patients develop ototitis media.…”

Section: Wg -Clinicalmentioning

confidence: 99%

Collagenolytic (necrobiotic) granulomas: part 1 – the ‘blue’ granulomas

Lynch

Barrett

2004

J Cutan Pathol

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A collagenolytic or necrobiotic non-infectious granuloma is one in which a granulomatous infiltrate develops around a central area of altered collagen and elastic fibers. The altered fibers lose their distinct boundaries and exhibit new staining patterns, becoming either more basophilic or eosinophilic. Within the area of altered collagen, there may be deposition of acellular substances such as mucin (blue) or fibrin (red), or there may be neutrophils with nuclear dust (blue), eosinophils (red), or flame figures (red). These color distinctions can be used as a simple algorithm for the diagnosis of collagenolytic granulomas, i.e. 'blue' granulomas vs. 'red' granulomas. Eight diagnoses are included within these two groupings, which are discussed in this two-part article. In this first part, the clinical presentation, pathogenesis, and histologic features of the 'blue' collagenolytic granulomas are discussed. These are the lesions of granuloma annulare, Wegener's granulomatosis, and rheumatoid vasculitis. In the subsequent half of this two-part series, the 'red' collagenolytic granulomas will be discussed; these are the lesions of necrobiosis lipoidica, necrobiotic xanthogranuloma, rheumatoid nodules, Churg-Strauss syndrome, and eosinophilic cellulitis (Well's syndrome).Lynch JM, Barrett TL. Collagenolytic (necrobiotic) granulomas: part 1 -the 'blue' granulomas.

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“…Another penis ulcer as fi rst presentation of WG with a nonspecifi c histology, as in our case, is reported in this issue [3] . Four previous cases have been described in the literature with such a presentation as the fi rst clinical sign of the disease [4][5][6][7] . c-ANCA (serum antibodies directed against cytoplasmic components of neutrophils) are highly specifi c for WG.…”

Section: Commentmentioning

confidence: 99%