Wegener's granulomatosis

Lim, Kin Sheng; Lee, Graham; Pavesio, Carolos E; Ficker, Linda

doi:10.1136/bjo.87.4.500

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Ocular and orbital involvement arises in 20% to 50% of patients with generalized WG , indeed orbital involvement can be the initial clinical manifestation of the disease . However, 60% of patients with ocular disease of WG can develop significant local complications that include ischaemic optic neuropathy, optic nerve oedema, optic atrophy, corneal melt and uni/or bilateral vision loss .…”

Section: Ocular and Orbital Diseasementioning

confidence: 99%

Wegener's granulomatosis: a review of clinical features and an update in diagnosis and treatment

Almouhawis

Leão

Fedele

et al. 2013

J Oral Pathology Medicine

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Wegener's granulomatosis (WG) is an idiopathic, systemic inflammatory disease characterized by necrotizing granulomatous inflammation and pauci-immune small-vessel vasculitis of upper and lower respiratory tract and kidneys. The condition affects both genders equally, although some inconsistent gender differences have been observed. The aetiology of WG remains unknown although a number of exogenous factors have been suggested to be of aetiological relevance. Most clinical characteristics of this disease are non-specific, making clinical diagnosis challenging. Histopathological examination of lesional and peritoneal tissue is not pathognomonic, but is an essential investigation to confirm the presence of disease and exclude other disorders. At present, despite the increasingly wide range of potential therapies, cyclophosphamide plus corticosteroids remain the most recognized and effective means of inducing and sustaining remission of WG.

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Section: Ocular and Orbital Diseasementioning

confidence: 99%

Wegener's granulomatosis: a review of clinical features and an update in diagnosis and treatment

Almouhawis

Leão

Fedele

et al. 2013

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…Our patient had severe renal impairment which was irreversible even after the initiation of rituximab treatment. His treatment course suggests that the early use of rituximab in patients with severe WG is recommended to prevent irreversible systemic and ocular damage 14 …”

Section: Discussionmentioning

confidence: 99%