Psychosocial well-being during the Coronavirus disease 2019 (COVID-19) pandemic had been reported in the world. But, less knowledge about the role of governmental interventions was explored in a country with civil conflicts. The present study aims to investigate the association of governmental interventions with psychosocial well-being and their moderators in Colombia. The mean age of study participants was 51.05 years (SD=±13.64, N=747) and 50.53% were men. Street vendors were likely to be mentally vulnerable in the ongoing COVID-19 pandemic. Economic support from the government (adjusted odds ratio (aOR)=0.683, 95% confidence interval (CI): 0.443, 1.054), subsidy beneficiary (aOR=0.597, 95% CI: 0.412, 0.867), governmental opening of business places and dates (aOR=0.429, 95% CI: 0.311, 0.593), access to governmental programs (aOR=0.442, 95% CI: 0.312, 0.627) was significantly associated with yesterday depression, respectively. Simple slope analysis revealed that when average work hours per day were longer, the benefits of access to governmental programs on increased mental disorders was stronger. Thus, most of street vendors experienced war trauma, business difficulties, and mental disorders and distrusted in governmental agencies, police, council, and service. This study highlighted the importance of lengthening average work hours per day in improving mental and physical health among the street vendors.