Weekly administration of prostaglandin E2 gel compared with expectant management in women with previous cesareans

Rayburn, William F.; Gittens, Lisa; Lucas, Michael J.; Gall, Stanley A.; Gómez-Martín, M. Esther

doi:10.1016/s0029-7844(99)00300-2

Cited by 18 publications

(10 citation statements)

References 12 publications

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“…In our study the rate of uterine rupture after prostaglandin induction of labour with or without previous Cesarean was 2.5% and 0.033%, respectively. This is similar to the data shown by other investigators [10][11][12][13][14][15][16]. The risk of uterine rupture is influenced by many factors including birth weight, gestational age, race, country and maternal characteristics [17,18].…”

Section: Discussionsupporting

confidence: 90%

“…There are no recent randomised controlled trails of labour induction in women with previous cesarean section [12]. There is one controlled randomised study comparing weekly administration of prostaglandin gel to expectant management in women with prior cesarean delivery [13]. However, this is not applicable to majority of patients who require induction due to various medical and obstetric reasons where pregnancy should be terminated within 24-48 hours.…”

Section: Discussionmentioning

confidence: 99%

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Induction of Labor with PGE2 after One Previous Cesarean Section: 18 Years Experience in a University Hospital

Qahtani¹,

Borshaid²,

Enezi³

2011

IJCM

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Objective: To review the outcome of prostaglandin induction of labor in term pregnant women with previous one ce-sarean section compared to those without previous Cesarean section. Design: 18 years retrospective review of hospital records and case note review of index cases. Setting: University hospital. Population: Three hundred and twenty two women who had their labor induced with prostaglandin E2. One hundred and sixty one women had one previous Ce-sarean section. Methods: This study was conducted at King Fahad University Hospital, University of Dammam. It is a tertiary referral center with approximately 2300 births per year. We searched the hospital's records of deliveries from January 1992 to December 2009 and reviewed all indications and outcomes of prostaglandin induction of labor in women with one previous Cesarean section. The control group was composed of women who had their labor induced with prostaglandin but without previous Cesarean section. Main outcome measures: Labor outcome and uterine rup-ture Results: Three hundred and twenty two women were included. All received prostaglandin E2 for induction of labor. One hundred and sixty one women had one previous Cesarean section (study group) and the rest had no previous Ce-sarean section (control group). There was no difference in the rate of vaginal delivery between study and control group, 68.3% and 79.5% (p value 0.3), respectively. The rate of uterine rupture was 30 times higher in study group (2.5% Vs 0.033%). Conclusion: In women with one previous Cesarean section, induction of labor with prostaglandin leads to comparable rate of vaginal delivery similar to those without prior Cesarean section but with relatively high risk of uter-ine rupture

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Induction of Labor with PGE2 after One Previous Cesarean Section: 18 Years Experience in a University Hospital

Qahtani¹,

Borshaid²,

Enezi³

2011

IJCM

View full text Add to dashboard Cite

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“…Twenty-six studies [30–45, 48, 50–58] (90%) examined the effects of at least one pharmacologic agent on VBAC rates, including prostaglandins, oxytocin, mifepristone and epidural analgesia. Ten studies [31, 33, 43, 46–49, 53, 54, 57] (34%) examined non-pharmacologic or mechanical methods (membrane sweeping, amniotomy, balloon devices) in at least one intervention arm.…”

Section: Resultsmentioning

confidence: 99%

“…Of the studies reporting rupture or dehiscence, three [32, 45, 50] (10%) also reported uterine hyper-stimulation and three [41, 42, 44] (10%) also reported uterine atony; these outcomes were not included in analyses as they were considered clinically-related but distinct from the review’s outcomes of interest.…”

Section: Resultsmentioning

confidence: 99%

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Clinical interventions that influence vaginal birth after cesarean delivery rates: Systematic Review & Meta-Analysis

Wingert

Hartling

Sebastianski

et al. 2019

BMC Pregnancy Childbirth

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BackgroundTo systematically review the literature on clinical interventions that influence vaginal birth after cesarean (VBAC) rates.MethodsWe searched Ovid Medline, Ovid Embase, Wiley Cochrane Library, CINAHL via EBSCOhost; and Ovid PsycINFO. Additional studies were identified by searching for clinical trial records, conference proceedings and dissertations. Limits were applied for language (English and French) and year of publication (1985 to present). Two reviewers independently screened comparative studies (randomized or non-randomized controlled trials, and observational designs) according to a priori eligibility criteria: women with prior cesarean sections; any clinical intervention or exposure intended to increase the VBAC rate; any comparator; and, outcomes reporting VBAC, uterine rupture and uterine dehiscence rates. One reviewer extracted data and a second reviewer verified for accuracy. Meta-analysis was conducted using Mantel-Haenszel (random effects model) relative risks (VBAC rate) and risk differences (uterine rupture and dehiscence). Two reviewers independently conducted methodological quality assessments using the Mixed Methods Appraisal Tool (MMAT).ResultsTwenty-nine studies (six trials and 23 cohorts) examined different clinical interventions affecting rates of vaginal deliveries among women with a prior cesarean delivery (CD). Methodological quality was good overall for the trials; however, concerns among the cohort studies regarding selection bias, comparability of groups and outcome measurement resulted in higher risk of bias. Interventions for labor induction, with or without cervical ripening, included pharmacologic (oxytocin, prostaglandins, misoprostol, mifepristone, epidural analgesia), non-pharmacologic (membrane sweep, amniotomy, balloon devices), and combined (pharmacologic and non-pharmacologic). Single studies with small sample sizes and event rates contributed to most comparisons, with no clear differences between groups on rates of VBAC, uterine rupture and uterine dehiscence.ConclusionsThis systematic review evaluated clinical interventions directed at increasing the rate of vaginal delivery among women with a prior CD and found low to very low certainty in the body of evidence for cervical ripening and/or labor induction techniques. There is insufficient high-quality evidence to inform optimal clinical interventions among women attempting a trial of labor after a prior CD.

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Induction of labour for improving birth outcomes for women at or beyond term

Gülmezoglu

Crowther

Middleton

2006

Cochrane Database of Systematic Reviews

300

286

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Background-As a pregnancy continues beyond term the risks of babies dying inside the womb or in the immediate newborn period increase. Whether a policy of labour induction at a predetermined gestational age can reduce this increased risk is the subject of this review. Objectives-To evaluate the benefits and harms of a policy of labour induction at term or postterm compared with awaiting spontaneous labour or later induction of labour. Search methods-We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 March 2012). Selection criteria-Randomised controlled trials conducted in women at or beyond term. The eligible trials were those comparing a policy of labour induction with a policy of awaiting spontaneous onset of labour. Cluster-randomised trials and cross-over trials are not included. Quasi-random allocation schemes such as alternation, case record numbers or open randomnumber lists were not eligible. Data collection and analysis-Two review authors independently assessed trials for inclusion. Two review authors independently assessed trial quality and extracted data. Data were

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Weekly administration of prostaglandin E2 gel compared with expectant management in women with previous cesareans

Abstract: Although its safety was confirmed for outpatient use, weekly doses of intracervical PGE2 did not improve the likelihood of vaginal births after cesareans.

Cited by 18 publications

References 12 publications

Induction of Labor with PGE2 after One Previous Cesarean Section: 18 Years Experience in a University Hospital

Induction of Labor with PGE2 after One Previous Cesarean Section: 18 Years Experience in a University Hospital

Clinical interventions that influence vaginal birth after cesarean delivery rates: Systematic Review & Meta-Analysis

Induction of labour for improving birth outcomes for women at or beyond term

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