Weed growth inhibitors from<b><i>Aspergillus fischeri</i></b>TISTR 3272

Phattanawasin, Panadda; Pojchanakom, K; Sotanaphun, Uthai; Piyapolrungroj, Nusara; Zungsontiporn, Siriporn

doi:10.1080/14786410701766364

Cited by 28 publications

(16 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In earlier studies, the yield of terrein increased from 0.3 mg to 400 mg/L by microbial fermentation. 29,30 However, in our improved strategy, the average yield of purified terrein was found to be 1.14 g/L, which was higher than the existing reports. Thus, our results have opened a new way to produce and extract terrein in large quantities.…”

Section: Discussioncontrasting

confidence: 59%

Efficient Production of the Potent Antimicrobial Metabolite “Terrein” From the Fungus Aspergillus terreus

Goutam

Kharwar

Tiwari

et al. 2020

Natural Product Communications

View full text Add to dashboard Cite

The endophytic fungus Aspergillus terreus (JAS-2) derived from Achyranthes aspera possesses multiple bioactive metabolites, one of which is terrein, a potent antimicrobial substance. Here we report the improved biosynthesis of terrein in cultures grown in media with a fixed carbon and modified nitrogen source (4% dextrose, 1% casein) for 15 days, after which pure crystals of terrein were obtained in the culture medium. We suggest that our improved method is effective for improving the quantity and quality of terrein produced. Terrein has shown potent antimicrobial activities against various microbes that may lead to its further use to combat antimicrobial resistance which threatens the community worldwide.

show abstract

Section: Discussioncontrasting

confidence: 59%

Efficient Production of the Potent Antimicrobial Metabolite “Terrein” From the Fungus Aspergillus terreus

Goutam

Kharwar

Tiwari

et al. 2020

Natural Product Communications

View full text Add to dashboard Cite

show abstract

“…An example of a natural product with noteworthy biological activities is the fungal metabolite, terrein, isolated from Aspergillus terreus Thom. Terrein was first described in 1935 and was subsequently isolated from other strains of Aspergillus as well as Emericella and Penicilium (4)(5)(6). Terrein exhibits several biological activities including anti-inflammation, anti-melanogenesis, and anticancer properties.…”

Section: Introductionmentioning

confidence: 99%

Terrein inhibits migration of human breast cancer cells via inhibition of the Rho and Rac signaling pathways

et al. 2018

View full text Add to dashboard Cite

Breast cancer is the most common cancer in women worldwide. Progression and aggressiveness of breast cancer is usually associated with its migration and invasion abilities. Recently, natural products with potential anticancer activity have become attractive candidates for alternative treatment of cancer. A fungal metabolite, terrein, isolated from the Aspergillus terreus has been revealed to exhibit selective anticancer activity; although this molecule has a variety of biological activities. The inhibitory effect on cell proliferation in hepatoma, keratinocytes, and lung cancer cells was due to cell cycle arrest without induction of apoptosis. In contrast, its effects on cervical and breast cancer cells were mediated through activation of the apoptotic process. However, the effect of terrein on cell migration and invasion has not been explored. In the present study we analyzed the molecular effects of terrein on cell adhesion, cell migration, and cell invasion using two breast cancer cell lines, MCF-7 and MDA-MB-231, which exhibit different levels of invasiveness. Terrein induced apoptosis in both breast cancer cell lines in a dose-dependent manner. In addition, at a non-toxic concentration terrein exhibited a weak inhibition of cell adhesion, using either fibronectin or type IV collagen as substrates. Notably, terrein significantly inhibited both the migration and invasion abilities of MDA-MB-231 cells at the same non-toxic concentration. A marked decrease in MMP-2 and MMP-9 transcripts, as evaluated by real-time PCR, confirmed the anti-invasion effect of terrein at the transcriptional level. Western blot analyses revealed that terrein treatment suppressed RhoB expression and reduced Rac1 phosphorylation, leading to Rho GTPase inhibition. In addition, terrein-treated MCF-7 and MDA-MB-231 cells both displayed a scattered pattern of migration, suggesting that the suppression of RhoB and Rac1 disturbed the collective migration processes of breast cancer cells.

show abstract

“…Weed growth inhibitory activities: Weed growth inhibitory activity of 1 was determined at 2 µg/µL towards the monocotyledonous and dicotyledonous weeds, Echinochloa crusgalli and Mimosa pigra, respectively. The compound showed strong inhibition, especially on the root growth of both weeds [38].…”

Section: Anti-protozoal Activitiesmentioning

confidence: 97%

γ-Butyrolactones from Aspergillus Species: Structures, Biosynthesis, and Biological Activities

Ibrahim

Mohamed

Khedr

2017

Natural Product Communications

View full text Add to dashboard Cite

Recently, numerous metabolites possessing uncommon structures and potent bioactivity have been isolated from strains of fungi collected from diverse environments. The genus Aspergillus is known as a rich source of -butyrolactones. These are a group of fungal secondary metabolites, consisting of a fivemembered lactone bearing two aromatic rings, which shows a great variety of biological activities. This review summarizes the research on the biosynthesis, source, and biological activities of the naturally occurring -butyrolactones that have been isolated from Aspergillus species published over the last decades. More than 75 compounds are described and 65 references are cited.

show abstract

Weed growth inhibitors fromAspergillus fischeriTISTR 3272

Cited by 28 publications

References 8 publications

Efficient Production of the Potent Antimicrobial Metabolite “Terrein” From the Fungus Aspergillus terreus

Efficient Production of the Potent Antimicrobial Metabolite “Terrein” From the Fungus Aspergillus terreus

Terrein inhibits migration of human breast cancer cells via inhibition of the Rho and Rac signaling pathways

γ-Butyrolactones from Aspergillus Species: Structures, Biosynthesis, and Biological Activities

Contact Info

Product

Resources

About