In order to investigate the effect of weed control with common herbicides on yield and yield components of soybean ( Glycine max L.) Williams cultivar, two experiments were conducted using randomized complete block design with three replications at Agricultural and Natural Resources Research Center of Moghan during 2016-2017 and 2017-2018. Treatments consisted of Ethalfluralin, Imazethapyr, Trifluralin, Metribuzin, Bentazone and Alacolor herbicides with and without hand weeding control. The results showed that the number of pods per plant, biological yield, grain yield, and soybean protein percentage were statistically significant, but for plant height, growth period, chlorophyll index, 1000 seed weight and oil percent grain, the difference was not significant. The highest number of pods per plant (333.92), biological yield (1221 g.plant -1 ) and grain yield (2792 kg.ha -1 ) were obtained in hand weeding treatment. The results of the analysis of variance showed that the treatments had a significant difference in terms of herbicide efficiency percentage, density, and total weed dry weight. The results showed that one month after spraying, Trifluralin and Ethalfluralin herbicides had the highest effect on weed control. However, two months after herbicides spraying; all other treatments also showed their control effect. In this study, all weed control treatments significantly reduced the density and dry weight of weeds as compared to control treatment, but their effect was less than hand weeding. The highest grain yield (1896 kg.ha -1 ) and the highest biological yield (784.9 kg.ha -1 ) were observed in Ethalfluralin herbicide. Generally, based on the results of this study, the application of Ethalfluralin herbicide at rate of 2 L.ha -1 could be recommended for effective weed control in soybean production systems.