2014
DOI: 10.1016/j.ygyno.2014.07.102
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Wee1 is a novel independent prognostic marker of poor survival in post-chemotherapy ovarian carcinoma effusions

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Cited by 60 publications
(46 citation statements)
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“…Notably, WEE1 mRNA expression was significantly increased in CRC tissues compared with the corresponding adjacent normal tissues and the upregulation of WEE1 mRNA was observed in 41.9% of patients with CRC (18/43 cases). The upregulation of WEE1 mRNA in CRC is not only in agreement with the expression pattern of WEE1 in other human malignancy tissues, including HCC (16)(17)(18)(19), but also suggests WEE1 upregulation as a common event during the carcinogenesis of human malignancies, including CRC.…”
Section: Discussionsupporting
confidence: 77%
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“…Notably, WEE1 mRNA expression was significantly increased in CRC tissues compared with the corresponding adjacent normal tissues and the upregulation of WEE1 mRNA was observed in 41.9% of patients with CRC (18/43 cases). The upregulation of WEE1 mRNA in CRC is not only in agreement with the expression pattern of WEE1 in other human malignancy tissues, including HCC (16)(17)(18)(19), but also suggests WEE1 upregulation as a common event during the carcinogenesis of human malignancies, including CRC.…”
Section: Discussionsupporting
confidence: 77%
“…Although the upregulation of WEE1 has been observed in several human malignancies, including in HCC and melanoma, and in numerous types of tumor cell lines including glioblastoma and breast cancer (16)(17)(18)(19), the data regarding the expression pattern of WEE1 in human CRC remains limited. Using a cDNA array and semi-quantitative RT-PCR, Backert et al (26) identified that WEE1 expression was decreased in human colon cancer cell lines.…”
Section: Discussionmentioning
confidence: 99%
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“…The inhibitory phosphorylation of Tyr15 on CDK1 by WEE1 impedes CDK1/cyclin B function, resulting in cell-cycle arrest at G2-M and DNA-damage repair. [1] WEE1 is expressed at high levels in a number of cancers and is associated with poor clinical outcome, [5] suggesting that these cancers are heavily dependent on this mechanism for survival.…”
Section: Introductionmentioning
confidence: 99%