Wedge Resection for Bronchogenic Carcinoma in High-Risk Patients

Bk, Temeck; Pw, Schafer; Saini, Nirmal

doi:10.1097/00007611-199211000-00007

Cited by 12 publications

(7 citation statements)

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“…Acceptable results of segmentectomy in a large number of patients were reported by Jensik et al (1973). Since then, several retrospective studies (Breyer and Jensik, 1985;Stair et al, 1985;Jensik, 1987;Temeck et al, 1992) considering efficacy of limited resection have been reported. In 1995, the Lung Cancer Study Group (LCSG) published final results of a randomised controlled trial (RCT) (Ginsberg and Rubinstein, 1995;Lederle, 1996) comparing local recurrence and survival after limited resection with those after standard lobectomy for stage IA nonsmall-cell lung cancer (NSCLC).…”

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confidence: 99%

Survival following lobectomy vs limited resection for stage I lung cancer: a meta-analysis

et al. 2005

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Extent of resection needed to treat lung cancer has long been an issue. The sole randomised controlled trial, reported by the Lung Cancer Study Group, advised against limited resection as standard surgery even for small peripheral non-small-cell lung cancers (p3 cm), because of frequent local recurrences. Elsewhere, conflicting results have been reported from different institutions. We therefore conducted a meta-analysis of reported studies to compare survival of stage I patients between limited resection and standard lobectomy. A MEDLINE web search for computer-archived bibliographic data yielded 14 articles suitable for analysis. Combined survival differences (survival rate with lobectomy minus that with limited resection) at 1, 3, and 5 years after resection according to the DerSimonian -Laird random effects model were 0.7% (95% CI, À0.8 to 2.1; P ¼ 0.3659), 1.9% (95% CI, À3.7 to 7.4; P ¼ 0.5088), and 3.6% (95% CI, À0.4 to 10.5; P ¼ 0.3603), respectively. None of these survival differences were significant, indicating that survival after limited resection for stage I lung cancer was comparable to that after lobectomy. However, since interstudy heterogeneity was detected, caution is required in interpretation of the results.

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confidence: 99%

Survival following lobectomy vs limited resection for stage I lung cancer: a meta-analysis

et al. 2005

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“…Segmentectomy or wedge resection may be used as an alternative procedure. However, several studies 1,2) revealed higher incidence of locoregional recurrence in this limited resection group. For this reason, a pilot study with a combination therapy of wedge lung resection and postoperative radiation was performed to confirm its feasibility as a curative therapeutic modality.…”

Section: Introductionmentioning

confidence: 74%

“…Regarding the safety of the limited operation, Temeck et al 1) reported a 1.4% perioperative mortality rate and a 4.1% morbidity rate in the study of high-risk patients group who underwent wedge lung resection. Pastorino et al 2) and Hoffmann et al 3) also reported low operative mortality (0%) in the limited resection group compared to the high mortality rate (3-5%) in the lobar resection group.…”

Section: Discussionmentioning

confidence: 99%

Limited Operation for Lung Cancer in Combination with Post-operative Radiation Therapy

Kaneda

Watanabe

Tarukawa

et al. 2004

Chest

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“…Patients are usually selected to be in clinical stage I, but assessment can be inaccurate with one study reporting 32% of cases in either stage II or III. Local recurrence rates are higher than those anticipated with lobectomy, ranging from 14%115 to 23%116 overall, and are considerably higher when stage III lesions are considered (59%) 114. Long term survival rates appear to be between 5% and 10%, less favourable than with lobectomy,112 116 although a prospective Lung Cancer Study Group randomised trial117 reported survival to be equivalent to that with lobectomy.…”

Section: Part Ii: Operabilitymentioning

confidence: 99%