Web-Based 2D NMR Spectroscopy Practice Problems

Abstract

2D NMR spectroscopy is regularly utilized for determination of organic structures. Problem-solving using a variety of 2D techniques is increasingly covered in the undergraduate curriculum. While several advanced texts provide some practice problems, these books are often expensive and aimed at graduate students. A free and publicly available set of 2D NMR problems with answers was developed to provide students an opportunity to develop their advanced structure elucidation skills.

SN1, E1, and E2 Reactions oftert-Amyl Compounds: Improved Analysis Using Computational Chemistry and ASAP-HSQC NMR Spectroscopy

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Data handling in NMR facilities and assignment of NMR spectra in synthetic chemistry labs: Why electronic structure validation should become part of the routine

“…However, this is only partially true—at a closer look, one of the reasons for the compelling success of the technique is the convenience of interpretation of the spectra: Indeed, the extraction of information even from modern 2D experiments is fairly straightforward to understand and to teach also for non‐experts. Thus, with the increased throughput by instrument automation, NMR spectrometers become more and more integrated even in undergraduate chemistry education . But when the overall level of knowledge may be considered sufficient for general spectra interpretation, the current problem is rather somewhere else: There is little knowledge and awareness about electronic data handling.…”

A review of online learning strategies for biological NMR techniques a survey of educators

“…The education literature includes practical examples and data to work through as group problems [Graham et al 2016] along with lab and group activities [Rocks & Stockland 2020]. Innovations such as virtual reality software for molecular modelling [Gandhi et al 2021], 3D printing of 2D spectra [Jones et al 2021] even iPad interactive software [Li et al 2014].…”