Wearable Sensor System for Detection of Lactate in Sweat

Currano, Luke J.; Sage, F. Connor; Hagedon, Matthew; Hamilton, Leslie; Patrone, Julia; Gerasopoulos, Konstantinos

doi:10.1038/s41598-018-33565-x

Cited by 138 publications

(105 citation statements)

References 38 publications

(32 reference statements)

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“…More recently, Currano et al [91] have reported a complete wearable sensor system for non-invasive detection of lactate in sweat. The device consists of a thin, flexible Kapton patch (2.5 x 7.5 cm) with on board power (lithium-ion battery) and controlling electronics that can collect, store and transmit data.…”

Section: Lactate Sensingmentioning

confidence: 99%

Organic Electrochemical Transistors as an Emerging Platform for Bio-Sensing Applications: A Review

et al. 2021

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Organic electrochemical transistors (OECTs) have been recognized as a major emerging technology in the area of flexible electronics in the last decade. Although they have yet to be incorporated in common electronic fabrication technologies, they have considerably advanced as an emerging platform for biosensing applications. The paper provides a comprehensive and critical review of the most important advances in the field of OECT-based biosensors. A brief description of the device physics is given with the most important equations and a comparison has been made with the conventional MOSFET devices and characteristic equations. The use of OECTs as an emerging biosensing platform has been explored and their application as biomolecule, enzyme, bacteria, viruses, cells, nucleotide detectors as well as electrophysiological and wearable sensors has been reported. Furthermore, trends have been extracted and described in the paper in terms of fabrication technologies, electrode materials and most importantly, the semiconducting polymer. Additionally, future perspectives on the development and fabrication technologies of these devices have been further explored.

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Section: Lactate Sensingmentioning

confidence: 99%

Organic Electrochemical Transistors as an Emerging Platform for Bio-Sensing Applications: A Review

et al. 2021

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“…Implantable devices for glucose will be discussed later. Sweat and surface electrode measurements have also been made for parameters such as lactate [ 32 , 33 ], ammonia [ 34 ] and glucose [ 35 , 36 ]. The device in [ 36 ] has the additional feature of being self-powered.…”

Section: Surface Devicesmentioning

confidence: 99%

In-Vivo Microsystems: A Review

French

2020

Sensors

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In-vivo sensors yield valuable medical information by measuring directly on the living tissue of a patient. These devices can be surface or implant devices. Electrical activity in the body, from organs or muscles can be measured using surface electrodes. For short term internal devices, catheters are used. These include cardiac catheter (in blood vessels) and bladder catheters. Due to the size and shape of the catheters, silicon devices provided an excellent solution for sensors. Since many cardiac catheters are disposable, the high volume has led to lower prices of the silicon sensors. Many catheters use a single sensor, but silicon offers the opportunity to have multi sensors in a single catheter, while maintaining small size. The cardiac catheter is usually inserted for a maximum of 72 h. Some devices may be used for a short-to-medium period to monitor parameters after an operation or injury (1–4 weeks). Increasingly, sensing, and actuating, devices are being applied to longer term implants for monitoring a range of parameters for chronic conditions. Devices for longer term implantation presented additional challenges due to the harshness of the environment and the stricter regulations for biocompatibility and safety. This paper will examine the three main areas of application for in-vivo devices: surface devices and short/medium-term and long-term implants. The issues of biocompatibility and safety will be discussed.

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“…Aerococcus viridans lactate oxidase (AvLCTO) is a prototypical example of lactate oxidase catalyzing the conversion of lactate to pyruvate and liberating H 2 O 2 as a by-product. It has been used to develop biosensors to measure lactate concentrations in various samples indirectly using H 2 O 2 [2,3]. In mammals, peroxisomal glycolate oxidase is responsible for conversion of glycolate to glyoxylate, eventually leading to a build-up of oxalate leading to kidney disease and therefore making glycolate oxidase a target for treatment of hyperoxaluria [4].…”

Section: Introductionmentioning

confidence: 99%

FMN-dependent oligomerization of putative lactate oxidase from Pediococcus acidilactici

et al. 2020

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Lactate oxidases belong to a group of FMN-dependent enzymes and they catalyze a conversion of lactate to pyruvate with a release of hydrogen peroxide. Hydrogen peroxide is also utilized as a read out in biosensors to quantitate lactate levels in biological samples. Aerococcus viridans lactate oxidase is the best characterized lactate oxidase and our knowledge of lactate oxidases relies largely to studies conducted with that particular enzyme. Pediococcus acidilactici lactate oxidase is also commercially available for e.g. lactate measurements, but this enzyme has not been characterized in detail before. Here we report structural characterization of the recombinant enzyme and its co-factor dependent oligomerization. The crystal structures revealed two distinct conformations in the loop closing the active site, consistent with previous biochemical studies implicating the role of loop in catalysis. Despite the structural conservation of active site residues, we were not able to detect either oxidase or monooxygenase activity when L-lactate was used as a substrate. Pediococcus acidilactici lactate oxidase is therefore an example of a misannotation of an FMNdependent enzyme, which catalyzes likely a so far unknown oxidation reaction.

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Wearable Sensor System for Detection of Lactate in Sweat

Cited by 138 publications

References 38 publications

Organic Electrochemical Transistors as an Emerging Platform for Bio-Sensing Applications: A Review

Organic Electrochemical Transistors as an Emerging Platform for Bio-Sensing Applications: A Review

In-Vivo Microsystems: A Review

FMN-dependent oligomerization of putative lactate oxidase from Pediococcus acidilactici

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