Wearable Printed Temperature Sensors: Short Review on Latest Advances for Biomedical Applications

Khan, Saleem; Ali, Shaukat; Khan, Arshad; Bermak, Amine

doi:10.1109/rbme.2021.3121480

Cited by 16 publications

(25 citation statements)

References 177 publications

(297 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The strong desire to monitor human health data is driving the rapid growth of wearable biosensing technologies. Among the different wearable biosensing devices, temperature measurement has proven to be an important physiological parameter [29]. The accurate and continuous measurement of the human core body temperature by a wearable device is of great significance for human healthcare and disease monitoring [30,31].…”

Section: Discussionmentioning

confidence: 99%

A Novel Non-Invasive Thermometer for Continuous Core Body Temperature: Comparison with Tympanic Temperature in an Acute Stroke Clinical Setting

Ajčević

Stella

Furlanis

et al. 2022

Sensors

View full text Add to dashboard Cite

There is a growing research interest in wireless non-invasive solutions for core temperature estimation and their application in clinical settings. This study aimed to investigate the use of a novel wireless non-invasive heat flux-based thermometer in acute stroke patients admitted to a stroke unit and compare the measurements with the currently used infrared (IR) tympanic temperature readings. The study encompassed 30 acute ischemic stroke patients who underwent continuous measurement (Tcore) with the novel wearable non-invasive CORE device. Paired measurements of Tcore and tympanic temperature (Ttym) by using a standard IR-device were performed 3–5 times/day, yielding a total of 305 measurements. The predicted core temperatures (Tcore) were significantly correlated with Ttym (r = 0.89, p < 0.001). The comparison of the Tcore and Ttym measurements by Bland–Altman analysis showed a good agreement between them, with a low mean difference of 0.11 ± 0.34 °C, and no proportional bias was observed (B = −0.003, p = 0.923). The Tcore measurements correctly predicted the presence or absence of Ttym hyperthermia or fever in 94.1% and 97.4% of cases, respectively. Temperature monitoring with a novel wireless non-invasive heat flux-based thermometer could be a reliable alternative to the Ttym method for assessing core temperature in acute ischemic stroke patients.

show abstract

Section: Discussionmentioning

confidence: 99%

A Novel Non-Invasive Thermometer for Continuous Core Body Temperature: Comparison with Tympanic Temperature in an Acute Stroke Clinical Setting

Ajčević

Stella

Furlanis

et al. 2022

Sensors

View full text Add to dashboard Cite

show abstract

“…3D printing can also be used to print certain electronics to be added to the drug delivery devices. 3D printed electronics such as biological sensors which can measure glucose, temperature and sweat can be printed [68][69][70]. The desired design can also be directly printed into or onto the device [71].…”

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

3D Printing in Triggered Drug Delivery Devices: A Review

Cheung

Lee

et al. 2022

Biomedical Materials & Devices

View full text Add to dashboard Cite

Triggered drug delivery devices use external stimulus to trigger the release of the drugs from the device. By controlling the exposure of the stimuli, it would allow for the control over the timing, duration and amount of drug being released from the device, improving drug efficacy. 3D printing uses on-demand deposition and crosslinking of materials to fabricate a product, increasing the customisability of the design and internal structure. By using 3D printing to fabricate triggered drug delivery devices, certain advantages such as complex geometries, gradient compositions, multi-material structures and embedded components can be conferred to the printed devices. In this review paper, triggered drug delivery devices which are fabricated using 3D printing techniques such as vat photopolymerisation and material extrusion are discussed. The advancement in certain areas of 3D printing, such as in multi-material 3D printing and hybrid additive manufacturing, which presents tremendous opportunities for fabricating future triggered drug delivery devices will also be reviewed.

show abstract

“…14 It is important to thoroughly evaluate the potential risk of PMMA for long-term skin contact, as it may not be safe as other biocompatible polymers like poly(dimethyl siloxane). 3,15 In particular, using PMMA with molecular weights (MWs) ranging from 3,000 to 50,000 g/mol is attractive as a material for constructing WDs. [16][17][18] Nevertheless, most of the biological effects assessments of PMMA have been performed in conjunction with other compounds, and the MW has been overlooked.…”

Section: Introductionmentioning

confidence: 99%

“…Remarkably, Trinh et al reported the use of a PMMA‐based microfluidic device (2.4 mg of PMMA/cm 2 ) for sensing applications 14 . It is important to thoroughly evaluate the potential risk of PMMA for long‐term skin contact, as it may not be safe as other biocompatible polymers like poly(dimethyl siloxane) 3,15 . In particular, using PMMA with molecular weights (MWs) ranging from 3,000 to 50,000 g/mol is attractive as a material for constructing WDs 16–18 .…”

Section: Introductionmentioning

confidence: 99%

In vitro assessment of inflammatory skin potential of poly(methyl methacrylate) at non‐cytotoxic concentrations

Barraza‐Vergara,

Carmona‐Sarabia,

Torres‐García

et al. 2023

J Biomedical Materials Res

View full text Add to dashboard Cite

Poly(methyl methacrylate) (PMMA) is considered an attractive substrate material for fabricating wearable skin sensors such as fitness bands and microfluidic devices. Despite its widespread use, inflammatory and allergic responses have been attributed to the use of this material. Therefore, the main objective of this study was to obtain a comprehensive understanding of potential biological effects triggered by PMMA at non‐cytotoxic concentrations using in vitro models of NIH3T3 fibroblasts and reconstructed human epidermis (RhE). It was hypothesized that concentrations that do not reduce cell viability are sufficient to activate pathways of inflammatory processes in the skin. The study included cytotoxicity, cell metabolism, cytokine quantification, histopathological, and gene expression analyses. The NIH3T3 cell line was used as a testbed for screening cell toxicity levels associated with the concentration of PMMA with different molecular weights (MWs) (i.e., MW ~5,000 and ~15,000 g/mol). The lower MW of PMMA had a half‐maximal inhibitory concentration (IC50) value of 5.7 mg/cm2, indicating greater detrimental effects than the higher MW (IC50 = 14.0 mg/cm2). Non‐cytotoxic concentrations of 3.0 mg/cm2 for MW ~15,000 g/mol and 0.9 mg/cm2 for MW ~5,000 g/mol) induced negative metabolic changes in NIH3T3 cells. Cell viability was severely reduced to 7% after the exposure to degradation by‐products generated after thermal and photodegradation degradation of PMMA. PMMA at non‐cytotoxic concentrations still induced overexpression of pro‐inflammatory cytokines, chemokines, and growth factors (IL1B, CXCL10, CCL5, IL1R1, IL7, IL17A, VEGFA, FGF2, IFNG, IL15) on the RhE model. The inflammatory response was also supported by histopathological and gene expression analyses of PMMA‐treated RhE, indicating tissue damage and gene overexpression. Results suggested that non‐cytotoxic concentrations of PMMA (3.0 to 5.6 mg/cm2 for MW ~15,000 g/mol and 0.9 to 2.1 mg/cm2 for MW ~5,000 g/mol) were sufficient to negatively alter NIH3T3 cells metabolism and activate inflammatory events in the RhE skin.

show abstract

Wearable Printed Temperature Sensors: Short Review on Latest Advances for Biomedical Applications

Cited by 16 publications

References 177 publications

A Novel Non-Invasive Thermometer for Continuous Core Body Temperature: Comparison with Tympanic Temperature in an Acute Stroke Clinical Setting

A Novel Non-Invasive Thermometer for Continuous Core Body Temperature: Comparison with Tympanic Temperature in an Acute Stroke Clinical Setting

3D Printing in Triggered Drug Delivery Devices: A Review

In vitro assessment of inflammatory skin potential of poly(methyl methacrylate) at non‐cytotoxic concentrations

Contact Info

Product

Resources

About