Wearable near-infrared optical probe for continuous monitoring during breast cancer neoadjuvant chemotherapy infusions

Teng, Fei; Cormier, Timothy; Sauer-Budge, Alexis F.; Chaudhury, Rachita; Pera, Vivian; Istfan, Raeef; Chargin, David; Brookfield, Samuel J.; Ko, Naomi; Roblyer, Darren

doi:10.1117/1.jbo.22.1.014001

Cited by 30 publications

(23 citation statements)

References 50 publications

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“…Not only is the instrumentation speeds improving, but the data processing speeding are too: acquiring optical properties and chromophore concentrations in real-time in now possible using neural networks (Zhao et al, 2018;Zhao et al, 2019). Wearable technologies are increasing in popularity, and the BOTLab has created a continuous wave wearable device for continuous mon-itoring during neoadjuvant chemotherapy (Teng et al, 2017). Given that absolute concentrations may not set prognostic thresholds, the continuous wave wearable may be a new direction for noninvasive monitoring in the clinic.…”

Section: Discussionmentioning

confidence: 99%

Clinical Feasibility of Diffuse Optical Spectroscopic Imaging for Sarcoma

Peterson

2016

Biomedical Optics 2016

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I have the best family and friends. You have created a support network that has allowed me to grow and overcome. I could not have done this without you. Darren, thank you for being my advisor. You have given me freedom to explore and discover. Bang, thank you for being my co-sponsor. You have coached me in the clinic and encouraged me with your unwavering enthusiasm for me and this project. I am grateful to my committee members, Cathie, Elise, and Ji, for guiding this project and me. I would like to acknowledge all members of the BOTLab, past and present, for their friendship and support, especially my fellow DOSI collaborators. Brannon, thank you for curiosity and patience while creating the phantom set. Professor Bigio, from my first year as an academic advisee to my final year as a Ph.D., you have been a steadfast mentor and an example of a student ally and advocate. I had a lot of help from my clinical collaborators. At Montefiore Medical Center and MD Anderson Cancer Center, I would like to acknowledge Drs. Bang Hoang, David Geller, Rui Yang, and Richard Gorlick. Thank you so much for your enthusiasm and support, you have been amazing collaborators. I also want to acknowledge Janet, Jeremy, and Damian, for coordinating measurements, consenting subjects, extracting patient data, documenting IRB amendments, and guiding me and this project. At Boston Medical Center, I would like to thank Liz, Salli, Jill, Meredith, Jen, Joanna, Malti, Debbie, and Nancy for all their help. Liz, I'll miss doing the DOSI-DO with you. For when everything falls apart, thank you Chris, Dan, and Eric at the Electronic Design Facility for helping me put it back together again. From measurements to data processing to repairs, I would also like to thank Anais, Amanda, and Tom for imparting all of their DOSI knowledge and wisdom. Within the Biomedical Engineerv ing Department, I'm so grateful for all the help, support, and laughs from Christen, Will, Allie, Stephanie, Nicole, and Tara.

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Section: Discussionmentioning

confidence: 99%

Clinical Feasibility of Diffuse Optical Spectroscopic Imaging for Sarcoma

Peterson

2016

Biomedical Optics 2016

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“…Fortunately, there has been a growing interest in academia and industry to develop more advanced and new optical wearables for RPM technologies. 31 breast cancer therapy monitoring, 32 and neuroapplications. 33 There has also been substantial development of smartphone-based optical platforms for dermoscopy and point-of-care diagnoses for an array of diseases and conditions.…”

Section: Areas Of Opportunity For the Biomedical Optics Community To mentioning

confidence: 99%

“…The table is limited to in vivo physiological monitoring and does not include optical technologies for quantifying biosamples such as blood, urine, feces, etc. Examples include diffuse optical wearables for fitness monitoring, 30 ambulatory monitoring, 31 breast cancer therapy monitoring, 32 and neuroapplications. 33 There has also been substantial development of smartphone-based optical platforms for dermoscopy and point-of-care diagnoses for an array of diseases and conditions.…”

Section: Introductionmentioning

confidence: 99%

Perspective on the increasing role of optical wearables and remote patient monitoring in the COVID-19 era and beyond

Roblyer

2020

J. Biomed. Opt.

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Significance: The COVID-19 pandemic is changing the landscape of healthcare delivery in many countries, with a new shift toward remote patient monitoring (RPM). Aim: The goal of this perspective is to highlight the existing and future role of wearable and RPM optical technologies in an increasingly at-home healthcare and research environment. Approach: First, the specific changes occurring during the COVID-19 pandemic in healthcare delivery, regulations, and technological innovations related to RPM technologies are reviewed. Then, a review of the current state and potential future impact of optical physiological monitoring in portable and wearable formats is outlined. Results: New efforts from academia, industry, and regulatory agencies are advancing and encouraging at-home, portable, and wearable physiological monitors as a growing part of healthcare delivery. It is hoped that these shifts will assist with disease diagnosis, treatment, management, recovery, and rehabilitation with minimal in-person contact. Some of these trends are likely to persist for years to come. Optical technologies already account for a large portion of RPM platforms, with a good potential for future growth. Conclusions: The biomedical optics community has a potentially large role to play in developing, testing, and commercializing new wearable and RPM technologies to meet the changing healthcare and research landscape in the COVID-19 era and beyond.

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“…Moreover, wearable technologies enable continuous and longitudinal monitoring of tissue hemodynamics in conscious, freely behaving subjects, thus advancing our understanding of cognitive processes and adaptive behavior. 20 , 21 Therefore, there is an urgent need to develop wearable, multimodality technologies that can noninvasively measure both blood flow and oxygenation in deep tissues to investigate pathologies and interventions for various vascular/cellular diseases.…”

Section: Introductionmentioning

confidence: 99%